199999-60-5
Chemical Structure
WP9QY
- CAS. Nr.: 199999-60-5
- Formula:C58H71N11O15S2
- Molecular Weight:1226.38
IUPAC Name: ((4R,7S,10S,13S,16S,19S,22R)-19-((1H-indol-3-yl)methyl)-22-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-13-(3-amino-3-oxopropyl)-10-(4-hydroxybenzyl)-16-(hydroxymethyl)-7-isobutyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexaazacyclotricosane-4-carbonyl)-L-tyrosine
InChIKey: OXRZFLLXMORPHO-XCLFSWKQSA-N
SMILES: O=C(N[C@H](C(N[C@H](C(N[C@H](C(N1)=O)CC(C=C2)=CC=C2O)=O)CCC(N)=O)=O)CO)[C@@H](NC([C@H](CSSC[C@H](NC([C@@H]1CC(C)C)=O)C(N[C@H](C(O)=O)CC(C=C3)=CC=C3O)=O)NC([C@@H](N)CC(C=C4)=CC=C4O)=O)=O)CC5=CNC6=CC=CC=C56
Biological Activity: WP9QY is an inhibitor targeting TNFα and RANKL, which blocks the TNFα-TNFR1 interaction and inhibits TNFα-mediated apoptosis, cytotoxicity and bone destruction. WP9QY inhibits osteoclastogenesis and promotes osteoblast differentiation, induces chondrocyte proliferation and glycosaminoglycan production, and synergizes with TGF-β3 to promote chondrogenesis. WP9QY effectively repairs full-thickness articular cartilage defects in rabbits via intra-articular injection, and inhibits methylmercury-induced reduction of NeuN-positive cells in mouse brain slices. WP9QY can be applied to the research of diseases related to methylmercury-induced neuronal death, cartilage injury, osteoarthritis and bone loss[1][2][3][4].
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WP9QY | 99.79% | WP9QY is an inhibitor targeting TNFα and RANKL, which blocks the TNFα-TNFR1 interaction and inhibits TNFα-mediated apoptosis, cytotoxicity and bone destruction. WP9QY inhibits osteoclastogenesis and promotes osteoblast differentiation, induces chondrocyte proliferation and glycosaminoglycan production, and synergizes with TGF-β3 to promote chondrogenesis. WP9QY effectively repairs full-thickness articular cartilage defects in rabbits via intra-articular injection, and inhibits methylmercury-induced reduction of NeuN-positive cells in mouse brain slices. WP9QY can be applied to the research of diseases related to methylmercury-induced neuronal death, cartilage injury, osteoarthritis and bone loss. | ||||||||||||||||||||
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References
- [1]. Lin CC, et al. Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFalpha. Biomaterials. 2009;30(28):4907-4914. [Content Brief]
- [2]. Toyama T, et al. Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia. Sci Rep. 2021;11(1):9832. Published 2021 May 10. [Content Brief]
- [3]. Furuya Y, et al. Induction of chondrogenesis with a RANKL-binding peptide, WP9QY, in vitro and in vivo in a rabbit model. Biochem Biophys Res Commun. 2022;602:98-104. [Content Brief]
- [4]. Aoki K, et al. A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. J Clin Invest. 2006;116(6):1525-1534. [Content Brief]
