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Results for "

Troponin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arp2/3 Complex (1) Biochemical Assay Reagents (2) Calcium Channel (4) Caspase (1) Drug Derivative (2) Fungal (1) Glutathione Peroxidase (1) Interleukin Related (1) Isotope-Labeled Compounds (1) MAP3K (2) Phosphodiesterase (PDE) (2) PKC (1) Potassium Channel (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (1) Topoisomerase (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (15) Infection (1) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109121

Reldesemtiv 2 Publications Verification CK-2127107	Calcium Channel	Cardiovascular Disease
Reldesemtiv (CK-2127107) is a selective, orally active and next-generation fast skeletal muscle troponin activator (FSTA). Reldesemtiv selectively activates fast skeletal myofibrils with an EC₅₀ of 3.4 μM. Reldesemtiv increases exercise performance in a heart failure model .

HY-174374

Topobexin	Topoisomerase	Cardiovascular Disease
Topobexin is a TOP2B-selective inhibitor with IC₅₀ values of 0.19 μM and 4.8 μM for TOP2B and TOP2A (DNA decatenation assay). Topobexin binds to non-homologous residues in the obex pocket and targets the ATPase domain of TOP2B. Topobexin prevents anthracycline-induced DNA double-strand break formation, apoptotic signaling mediated by caspase 3/7, 8 and 9, cardiomyocyte morphological changes, mitochondrial depolarization/loss, left ventricular systolic dysfunction, extracellular matrix remodeling, fibrotic alterations, and increases in plasma cardiac troponin T and BNP. Topobexin does not impair the antiproliferative effects of anthracyclines in cancer cells, exhibits no intrinsic cytotoxicity in cardiomyocytes, and is well tolerated in rabbits. Topobexin can be used in studies related to anthracycline-induced cardiotoxicity .

HY-106844A

(+)-EMD 57033	Phosphodiesterase (PDE)	Cardiovascular Disease
(+)-EMD 57033 is a *cardiac troponin* C (cTnC*) activator, is a dominant Ca ²⁺ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin* C isoform and exerts myocardial contractile promotion function .

HY-15964

Tirasemtiv 1 Publications Verification CK-2017357	Biochemical Assay Reagents	Neurological Disease
Tirasemtiv is an activator of the fast skeletal muscle troponin complex. Tirasemtiv is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147292

Nelutroctiv CK-136	Calcium Channel	Cardiovascular Disease
Nelutroctiv (CK-136) is an orally active and selective cardiac troponin activator. Nelutroctiv activates cardiac sarcomeres by enhancing the sensitivity of troponin to calcium ions and promoting the interaction between actin and myosin. Nelutroctiv enhances cardiac contractility. Nelutroctiv can be used in the researches for cardiovascular diseases with impaired cardiac contractile function .

HY-119608

GSK854	MAP3K	Cardiovascular Disease
GSK854 is a potent Inhibitor of Troponin I-Interacting Kinase (TNNI3K). GSK854 is a suitable lead for identifying new cardiac medicines and have been employed as in vivo tools in investigational studies aimed at defining the role of TNNI3K within heart failure .

HY-162345

CK-963	Calcium Channel	Cardiovascular Disease
CK-963 is an activator for cardiac troponin (cTnC) with K_i of 11.5 μM. CK-963 exhibits activity in enhancing cardiac contractility in Sprague-Dawley rats .

HY-W996116

AZM198	Glutathione Peroxidase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
AZM198 is an orally active myeloperoxidase (MPO) inhibitor. AZM198 irreversibly inactivates MPO (IC₅₀=0.015 μM) via covalent binding to the heme prosthetic group, preferentially targets extracellular MPO activity, and reduces neutrophil extracellular trap formation, reactive oxygen species production and degranulation. AZM198 increases the fibrous cap thickness of atherosclerotic plaques, reduces lesion area, ameliorates hepatic steatosis and fibrosis in non-alcoholic steatohepatitis, and alleviates proteinuria and inflammatory infiltration associated with glomerulonephritis. AZM198 also decreases circulating levels of high-sensitivity *Cardiac Troponin* I and IL-1β**, and mitigates endothelial cell injury. Therefore, AZM198 is suitable for research on various MPO-related diseases, including atherosclerotic cardiovascular disease, myocardial infarction, ischemic stroke, non-alcoholic steatohepatitis and crescentic glomerulonephritis .

HY-124689

TR-100	Arp2/3 Complex	Metabolic Disease Cancer
TR-100 is a small molecule inhibitor of tumor-associated troponin (Tpm). TR-100 affects the interaction of Tpm3.1 with actin filaments by binding to the C-terminal of Tpm3.1, thereby affecting the stability and function of the actin filaments. This mechanism of action allows TR-100 to specifically affect actin filaments in cancer cells without compromising heart muscle function. TR-100 can be used to study the role of Tpm3.1 in cancer cell proliferation and survival and the effects of Tpm3.1 on insulin-stimulated glucose uptake and insulin secretion .

HY-117658

GSK-114	MAP3K	Cardiovascular Disease
GSK-114 is a highly selective, orally active TNNI3K inhibitor (IC₅₀= 25 nM). GSK-114 shows a 40-fold selectivity for TNNI3K over B-Raf kinase (IC₅₀= 1 μM). Cardiac troponin I-interacting kinase (TNNI3K or CARK) is a member of the tyrosine-like kinase family that is selectively expressed in heart tissue .

HY-175640

Troponin-IN-1	Pyroptosis Reactive Oxygen Species (ROS) Interleukin Related Caspase	Cardiovascular Disease
Troponin-IN-1 is a *troponin* inhibitor. Troponin-IN-1 protects OGD/R-injured H9c2 cardiomyocytes by reducing LDH leakage, pyroptosis and ROS accumulation. Troponin-IN-1 inhibits NO production and IL-1β/TNF-α/IL-18 release in LPS (HY-D1056)-induced RAW264.7 cells. Troponin-IN-1 acts via caspase-1/GSDMD/IL-18 pathway. Troponin-IN-1 reduces myocardial infarct size in LAD-induced myocardial ischemia/reperfusion (MI/R) male rats. Troponin-IN-1 can be used for the study of myocardial ischemia/reperfusion (MI/R) injury .

HY-P4108C

Cys-TAT-HA2	Phosphodiesterase (PDE)	Others
Cys-TAT-HA2 is a conjugate of Cys and TAT-HA2 (HY-P4108). Cys-TAT-HA2 is a transduction complex that can be introduced protein (such as *Cardiac troponin* C**) into the cytoplasm of living cells. Cys-TAT-HA2 can be used for live tracking of exogenous proteins research .

HY-131948

3-Chlorodiphenylamine	Potassium Channel	Cardiovascular Disease
3-Chlorodiphenylamine is a high affinity Ca ²⁺ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of *cardiac troponin* C (cTnC) (K_d=6 µM**). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca ²⁺-sensitizing compounds due to its small size, and can be used for systolic heart failure research .

HY-137749A

MANT-dADP trisodium 2'-Deoxy-3'-MANT-ADP trisodium	Biochemical Assay Reagents	Others
MANT-dADP (trisodium) (2'-Deoxy-3'-MANT-ADP (trisodium)) is a fluorescent nucleotide derivative, with an emission maximum of 453 nm upon excitation at 350 nm. MANT-dADP (trisodium) can decrease inositol phoshate formation in CHO-K1 cells that express human purinergic P2Y₁₂ receptor. MANT-dADP (trisodium) can be studied in research on the interaction between cardiac troponin I and myofibrils .

HY-176041

Troponin modulator 1	Calcium Channel	Cardiovascular Disease
Troponin modulator 1 (compound 7) modulates the mutant cardiac muscle thin filament function. Troponin modulator 1 enhances Ca ²⁺ sensitivity by phosphorylation with an EC₅₀ of 67 μM .

HY-130272

Anti-MI/R injury agent 1	Drug Derivative	Cardiovascular Disease
Anti-MI/R injury agent 1 (compound 18), a Panaxatriol derivative, is an orally active, potent anti-myocardial ischemia/reperfusion (anti-MI/R) injury agent. Anti-MI/R injury agent 1 enhances oxygen-glucose deprivation and reperfusion (OGD/R)-induced cardiomyocyte injury cell viability. Anti-MI/R injury agent 1 can markedly reduce myocardial infarction size, decrease circulating cardiac troponin I (cTnI) leakage, and alleviate cardiac tissue damage in the rats .

HY-176316S

Troponin I, U-15N	Isotope-Labeled Compounds	Cardiovascular Disease
Troponin I, U- ¹⁵N is the ¹⁵N-labeled Troponin I.

HY-N18070

12-Deoxyphorbol-13-isobutyrate-20-acetate	Drug Derivative PKC Fungal	Cardiovascular Disease Infection Inflammation/Immunology Cancer
12-Deoxyphorbol-13-isobutyrate-20-acetate is a 12-deoxy-phorbol diterpene ester. 12-Deoxyphorbol-13-isobutyrate-20-acetate is a protein kinase C (PKC) agonist that activates protein kinase C to phosphorylate troponin I and troponin T. 12-Deoxyphorbol-13-isobutyrate-20-acetate induces skin irritation and necrosis in mice without cocarcinogenic activity. 12-Deoxyphorbol-13-isobutyrate-20-acetate inhibits Aspergillus carbonarius growth. 12-Deoxyphorbol-13-isobutyrate-20-acetate supports research on heart failure, cardiomyopathies and fungal infection .

Cat. No.	Product Name	Target	Research Area

HY-P11206A

*Murine cardiac troponin* I peptide TFA** Murine cardiac TnI peptide TFA	Peptides	Inflammation/Immunology
Murine cardiac troponin I peptide (Murine cardiac TnI peptide) TFA is a murine cardiac troponin I (cTnI) peptide. Murine cardiac troponin I peptide TFA can induce significant myocardial inflammation followed by fibrosis and heart failure with increased mortality in mice model. Murine cardiac troponin I peptide TFA can be used for heart failure research .

HY-P4108C

Cys-TAT-HA2	Phosphodiesterase (PDE)	Others
Cys-TAT-HA2 is a conjugate of Cys and TAT-HA2 (HY-P4108). Cys-TAT-HA2 is a transduction complex that can be introduced protein (such as *Cardiac troponin* C**) into the cytoplasm of living cells. Cys-TAT-HA2 can be used for live tracking of exogenous proteins research .

HY-P11206

*Murine cardiac troponin* I peptide** Murine cardiac TnI peptide	Peptides	Cardiovascular Disease Inflammation/Immunology
Murine cardiac troponin I peptide (Murine cardiac TnI peptide) is a murine cardiac troponin I (cTnI) peptide. Murine cardiac troponin I peptide can induce significant myocardial inflammation followed by fibrosis and heart failure with increased mortality in mice model. Murine cardiac troponin I peptide can be used for heart failure research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N18070

12-Deoxyphorbol-13-isobutyrate-20-acetate	Structural Classification Euphorbia resinifera O. Berg Terpenoids Sesquiterpenes Euphorbiaceae Plants Source Classification	Drug Derivative PKC Fungal
12-Deoxyphorbol-13-isobutyrate-20-acetate is a 12-deoxy-phorbol diterpene ester. 12-Deoxyphorbol-13-isobutyrate-20-acetate is a protein kinase C (PKC) agonist that activates protein kinase C to phosphorylate troponin I and troponin T. 12-Deoxyphorbol-13-isobutyrate-20-acetate induces skin irritation and necrosis in mice without cocarcinogenic activity. 12-Deoxyphorbol-13-isobutyrate-20-acetate inhibits Aspergillus carbonarius growth. 12-Deoxyphorbol-13-isobutyrate-20-acetate supports research on heart failure, cardiomyopathies and fungal infection .

Species:	Human (3) Mouse (2)
Tag:	SUMO (1) His (5) Flag (1)
Source:	E. coli (5)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71469

	*Cardiac troponin* I/Tnni3 Protein, Mouse (His-SUMO)** Tnni3; Troponin I; cardiac muscle; Cardiac Troponin I	Mouse	E. coli
	Cardiac troponin I, also known as Tnni3, plays a key role as an inhibitory subunit in the troponin complex, a key regulator of calcium sensitivity in actomyosin ATPase activity in striated muscle.Tnni3 interacts with TRIM63, emphasizing its involvement in complex cellular processes.Cardiac troponin I/Tnni3 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Cardiac troponin I/Tnni3 protein, expressed by E.coli , with N-SUMO, N-6*His labeled tag.

HY-P71372

	Troponin C/TNNC1 Protein, Human (His, solution) CMH7; TNNC1; TNNI3; Troponin I	Human	E. coli
	Troponin C, represented by the TNNC1 gene, centrally regulates striated muscle contraction. In the troponin complex consisting of Tn-I, Tn-T, and Tn-C, Tn-I inhibits the actomyosin ATPase, while Tn-T binds to tropomyosin. Troponin C/TNNC1 Protein, Human (His) is the recombinant human-derived Troponin C/TNNC1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71372A

	Troponin C/TNNC1 Protein, Human (N-His) CMH7; TNNC1; TNNI3; Troponin I	Human	E. coli
	Troponin C, represented by the TNNC1 gene, centrally regulates striated muscle contraction. In the troponin complex consisting of Tn-I, Tn-T, and Tn-C, Tn-I inhibits the actomyosin ATPase, while Tn-T binds to tropomyosin. Troponin C/TNNC1 Protein, Human (N-His) is the recombinant human-derived Troponin C/TNNC1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P703646

	Tnnt2 Protein, Mouse (His, Flag) Troponin T, cardiac muscle; TnTc; Cardiac muscle Troponin T (cTnT)	Mouse	E. coli
	Tnnt2 Protein, Mouse (His, Flag) is the recombinant mouse-derived Tnnt2, expressed by E. coli , with C-6*His, C-Flag labeled tag. ,

HY-P705691

	*Cardiac troponin* I/Tnni3 Protein, Human (His)**	Human	E. coli

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Cat. No.	Product Name	Chemical Structure

HY-176316S

Troponin I, U-15N
Troponin I, U- ¹⁵N is the ¹⁵N-labeled Troponin I.

Host:	Mouse (6) Rabbit (7)
Reactivity:	Human (13) Rat (8) Mouse (10)
Application:	IHC-P (9) ICC/IF (5) IF-Tissue (3) IP (4) IHC-F (2) WB (9) FC (4) ELISA (6)
Isotype:	IgG (9) IgG1 (4)
Conjugation:	Non-conjugated (13)
Clonality:	Monoclonal (9) Recombinant (5)
Modification:	Unmodified (10)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82087

	Troponin I Antibody (YA1832) TNNI2; Troponin I; fast skeletal muscle; Troponin I; fast-twitch isoform	WB, IP	Human, Mouse, Rat
	Troponin I Antibody (YA1832) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Troponin I.

HY-P85398

	*Cardiac Troponin* I Antibody (YA5090)** TNNI3; TNNC1; Troponin I; cardiac muscle; Cardiac Troponin I	IHC-P, IHC-F, IF-Tissue	Human, Rat, Mouse
	Cardiac Troponin I Antibody (YA5090) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cardiac Troponin I.

HY-P86427

	*Cardiac Troponin* I Antibody (YA6119)** TNNI3; TNNC1; Troponin I; cardiac muscle; Cardiac Troponin I	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Cardiac Troponin I Antibody (YA6119) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cardiac Troponin I.

HY-P86432

	*Cardiac Troponin* T Antibody (YA6124)** TNNT2; Troponin T, cardiac muscle; TnTc; Cardiac muscle Troponin T; cTnT	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Cardiac Troponin T Antibody (YA6124) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cardiac Troponin T.

HY-P85399

	Troponin I-FS Antibody (YA5091) TNNI2; Troponin I; fast skeletal muscle; Troponin I, fast-twitch isoform	WB, IP	Human, Mouse, Rat
	Troponin I-FS Antibody (YA5091) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Troponin I-FS.

HY-P85398A

	*Cardiac Troponin* I Antibody (YA5090)(PBS only)** TNNI3; TNNC1; Troponin I; cardiac muscle; Cardiac Troponin I	IHC-P, IHC-F, IF-Tissue	Human, Rat, Mouse
	Cardiac Troponin I Antibody (YA5090) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cardiac Troponin I.

HY-P81144

	*Cardiac Troponin* I Antibody (YA3484)** Troponin I type 3 (cardiac); Cardiac Troponin I; Troponin I, cardiac muscle; Cardiomyopathy, familial hypertrophic, 7, included; CMD1FF; CMD2A; CMH7; cTnI; Familial hypertrophic cardiomyopathy 7; MGC116817; RCM1; Tn1; Tni; TNN I3; TNNC 1; TNNC-1; TNNC1; TNNI3; Troponin I cardiac; Troponin I cardiac muscle; Troponin I cardiac muscle isoform; Troponin I type 3 cardiac; Troponin I, cardiac 3; TroponinI; Troponin I; TNNI3_HUMAN.	WB, IHC-P, ICC/IF, IP	Human
	Cardiac Troponin I Antibody (YA3484) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cardiac Troponin I.

HY-P82380

	*Cardiac Troponin* I/TNNC1 Antibody (YA2125)** tnnc1a; TNC; Tnnc1; TNNI3; Troponin C	WB, IHC-P	Human, Mouse, Rat
	Cardiac Troponin I/TNNC1 Antibody (YA2125) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cardiac Troponin I/TNNC1.

HY-P82974

	*Cardiac Troponin* T Antibody (YA2719)** TNNT2; Cardiac muscle Troponin T; Troponin T; cardiac muscle; Troponin T type 2 (cardiac); Cardiac muscle Troponin T antibody Cardiomyopathy dilated 1D (autosomal dominant) antibody; Cardiomyopathy hypertrophic 2 antibody; CMD1D antibody; CMH2 antibody; CMPD2 antibody; cTnT antibody; LVNC6 antibody; MGC3889 antibody; OTTHUMP00000033864 antibody; RCM3 antibody; TNNT 2 antibody; TNNT2 antibody; TNNT2_HUMAN antibody; TnTc antibody; Troponin T cardiac muscle antibody; Troponin T2 cardiac antibody	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
	Cardiac Troponin T Antibody (YA2719) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cardiac Troponin T.

HY-P84352

	Troponin I Antibody (YA4049) DA2B; FSSV; fsTnI; AMCD2B	ICC/IF, FC, ELISA	Human
	Troponin I Antibody (YA4049) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Troponin I.

HY-P84352A

	Troponin I Antibody (YA4049)(PBS only) DA2B; FSSV; fsTnI; AMCD2B	ICC/IF, FC, ELISA	Human
	Troponin I Antibody (YA4049) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Troponin I.

HY-P84334

	*Cardiac Troponin* T Antibody (YA4031)** CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6	WB, IHC-P, FC, ELISA	Human, Mouse
	Cardiac Troponin T Antibody (YA4031) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cardiac Troponin T.

HY-P84334A

	*Cardiac Troponin* T Antibody (YA4031)(PBS only)** CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6	WB, IHC-P, FC, ELISA	Human, Mouse
	Cardiac Troponin T Antibody (YA4031) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cardiac Troponin T.

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HY-15964

Tirasemtiv 1 Publications Verification CK-2017357		Alkynes
Tirasemtiv is an activator of the fast skeletal muscle troponin complex. Tirasemtiv is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Troponin

Inhibitors & Agonists

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