1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. 3-Chlorodiphenylamine

3-Chlorodiphenylamine 

Cat. No.: HY-131948
Handling Instructions

3-Chlorodiphenylamine is a high affinity Ca2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (Kd=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca2+-sensitizing compounds due to its small size, and can be used for systolic heart failure research.

For research use only. We do not sell to patients.

3-Chlorodiphenylamine Chemical Structure

3-Chlorodiphenylamine Chemical Structure

CAS No. : 101-17-7

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Description

3-Chlorodiphenylamine is a high affinity Ca2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (Kd=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca2+-sensitizing compounds due to its small size, and can be used for systolic heart failure research[1].

IC50 & Target

Kd: 6 µM (N-domain of cardiac troponin C (cTnC))
Kd: 10 µM (cNTnC–cSp chimera)[1]

In Vitro

3-Chlorodiphenylamine is able to bind highly (Kd=10 µM) to a chimeric protein consisting of the regulatory N-domain of cTnC (cNTnC) and the switch region of cTnI (cNTnC–cSp chimera)[1].
3-Chlorodiphenylamine (100 µM) results in a 1.5-fold increase in the Ca2+ sensitivity of force development without altering the maximal or resting forces in skinned ventricular trabeculae[1].
3-Chlorodiphenylamine (25-100 µM) increases Ca2+ sensitivity of the N-domain of intact cTnC after reconstitution into the cTn complex (cTnC complexed with cTnI and cTnT) in a concentration-dependent manner. It exhibits pCa50s with 6.39±0.01, 6.65±0.01, and 6.73±0.02 in the presence of 25, 50, and 100 µM 3-Chlorodiphenylamine, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

203.67

Formula

C₁₂H₁₀ClN

CAS No.

101-17-7

SMILES

ClC1=CC(NC2=CC=CC=C2)=CC=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

3-ChlorodiphenylaminePotassium ChannelKcsACa2+ sensitizersystolic heart failurecardiac musclescaffoldcTnCInhibitorinhibitorinhibit

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3-Chlorodiphenylamine
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