1301761-96-5
1301761-96-5
Chemical Structure
GSK-114
- CAS No.: 1301761-96-5
- Formula:C19H23N5O4S
- Molecular Weight:417.48
IUPAC Name: 3-((6,7-dimethoxyquinazolin-4-yl)amino)-4-(dimethylamino)-N-methylbenzenesulfonamide
InChIKey: YUSROMRPOFFTMX-UHFFFAOYSA-N
SMILES: O=S(NC)(C1=CC=C(N(C)C)C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)=C1)=O
Biological Activity: GSK-114 is a highly selective, orally active TNNI3K inhibitor (IC50= 25 nM). GSK-114 shows a 40-fold selectivity for TNNI3K over B-Raf kinase (IC50= 1 μM). Cardiac troponin I-interacting kinase (TNNI3K or CARK) is a member of the tyrosine-like kinase family that is selectively expressed in heart tissue[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GSK-114 | 99.52% | GSK-114 is a highly selective, orally active TNNI3K inhibitor (IC50= 25 nM). GSK-114 shows a 40-fold selectivity for TNNI3K over B-Raf kinase (IC50= 1 μM). Cardiac troponin I-interacting kinase (TNNI3K or CARK) is a member of the tyrosine-like kinase family that is selectively expressed in heart tissue. | ||||||||||||||||||||
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