2387506-35-4
Chemical Structure
Anti-MI/R injury agent 1
- CAS No.: 2387506-35-4
- Formula:C32H49NO6
- Molecular Weight:543.73
IUPAC Name: (1S,3aR,3bR,5S,10aR,12R)-5,12-dihydroxy-3a,3b,6,6,10a-pentamethyl-1-((R)-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazole-9-carboxylic acid
InChIKey: XOCSPWXQUIGBRU-GGYYVHFSSA-N
SMILES: CC1(C)C2=C(C(C(O)=O)=NO2)C[C@@]3(C)C1[C@@H](O)C[C@]4(C)C3C[C@@H](O)C5[C@@]4(C)CC[C@]5([H])[C@@]6(C)CCCC(C)(C)O6
Biological Activity: Anti-MI/R injury agent 1 (compound 18), a Panaxatriol derivative, is an orally active, potent anti-myocardial ischemia/reperfusion (anti-MI/R) injury agent. Anti-MI/R injury agent 1 enhances oxygen-glucose deprivation and reperfusion (OGD/R)-induced cardiomyocyte injury cell viability. Anti-MI/R injury agent 1 can markedly reduce myocardial infarction size, decrease circulating cardiac troponin I (cTnI) leakage, and alleviate cardiac tissue damage in the rats[1].
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Anti-MI/R injury agent 1 | Anti-MI/R injury agent 1 (compound 18), a Panaxatriol derivative, is an orally active, potent anti-myocardial ischemia/reperfusion (anti-MI/R) injury agent. Anti-MI/R injury agent 1 enhances oxygen-glucose deprivation and reperfusion (OGD/R)-induced cardiomyocyte injury cell viability. Anti-MI/R injury agent 1 can markedly reduce myocardial infarction size, decrease circulating cardiac troponin I (cTnI) leakage, and alleviate cardiac tissue damage in the rats. | |||||||||||||||||||||
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