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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
Type-II-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "Type-II-IN-1" in MCE Product Catalog:
Cat. No.: HY-18911
CAS No.: 1419299-81-2
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Type-II-IN-1 (Compound 3) is a type II spleen tyrosine kinase (Syk) inhibitor with an IC50 of 2.1 nM. Type-II-IN-1 can bind to the DFG-out conformation of Syk. Type-II-IN-1 can be used for the research of immunology, such as asthma [1].
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Cat. No.: HY-W012985
CAS No.: 600-22-6
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Methyl pyruvate is a p53/p21 axis inhibitor, intrinsic apoptosis inhibitor, cytotoxic agent, ATP production enhancer, proteasome function restorer, TDP-43 localization normalizer, ATP-sensitive potassium (K +ATP) channel inhibitor, depolarizer, and insulin secretagogue [1] .Methyl pyruvate turns off apoptotic pathways, induces cancer cell death, acts as a substrate for dimeric dihydrodiol dehydrogenase, enhances TCA cycle activity, rescues proteasome impairment and TDP-43 mislocalization, inhibits K +ATP channels independent of ATP, depolarizes pancreatic β-cell membranes, modulates insulin secretion, and enters pancreatic β-cell mitochondria via a specific transporter [1] .Methyl pyruvate can be used for the research of lung adenocarcinoma, ovarian clear cell adenocarcinoma, breast adenocarcinoma, amyotrophic lateral sclerosis, and type II diabetes .
Synonyms: meso-Nordihydroguaiaretic acid; meso-NDGA
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Cat. No.: HY-16619
CAS No.: 1222088-90-5
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AM-5262 is a GPR40 full agonist with an EC50 value of 0.081 μM. AM-5262 can be used for the research of type II diabetes .
Synonyms: R1439; RO0728804
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Aleglitazar (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes .
Cat. No.: HY-P3675
CAS No.: 51776-33-1
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Cat. No.: HY-114632
CAS No.: 280585-34-4
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Oxeglitazar is an orally active compound that can be used for the research of type II diabetes .
Cat. No.: HY-141653
CAS No.: 2056254-98-7
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MK-8666 (tromethamine) is a GPR40 agonist. MK-8666 (tromethamine) can be used in the research of type II diabetes .
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Thiazinamium (chloride) possesses potent anticholinergic and antiallergic activity and inhibits TxB2 synthesis with IC50 value of 0.2 µM. Thiazinamium (chloride) is structurally similar to H-1 antagonists Promethazine (HY-B1296). Thiazinamium (chloride) stimulates the phosphatidylcholine secretion in adult rat type II pneumocytes .
Cat. No.: HY-19859
CAS No.: 1163719-08-1
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AMG-222 (tosylate) is a DPP-IV inhibitor that can be used in the research of type II diabete .
Cat. No.: HY-N12191
CAS No.: 155944-24-4
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Alkaloids Other Alkaloids Terpenoids Sesquiterpenes Celastraceae Plants Tripterygium wilfordii Hook. f.
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Cat. No.: HY-162042
CAS No.: 1356632-18-2
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AMPK activator 14 (compound 32) is an orally active AMPK activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes .
Cat. No.: HY-109500R
CAS No.: 27686-84-6
Synonyms: meso-Nordihydroguaiaretic acid (Standard); meso-NDGA (Standard)
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Cat. No.: HY-120223
CAS No.: 170686-10-9
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BMS-196085 is an orally active, potent and selective full agonist against human β3 adrenergic receptor with a Ki value of 21 nM. BMS-196085 also has partial agonist activity at the β1 receptor. BMS-196085 is promising for research of obesity and type-II diabetes .
Cat. No.: HY-161429
CAS No.: 2152667-21-3
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Antidiabetic agent 5 (compound S1) is a antidiabetic agent. Antidiabetic agent 5 inhibits the activity of α-glucosidase and α-amylase with IC50 values of 3.91，8.89 μM，respectively. Antidiabetic agent 5 decreases sugar levels. Antidiabetic agent 5 has the potential for the research of type-II diabetes .
Cat. No.: HY-W011303S
Synonyms: 4-HydroxysphINganINe-d7
Cat. No.: HY-145538
CAS No.: 146877-98-7
Synonyms: 5'-Deoxyguanylic acid disodium hydrate
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2'-Deoxyguanosine 5'-monophosphate (5'-Deoxyguanylic acid; dGMP) disodium hydrate is an oxidizable target of the photosensitizer pterin (PT) and can be used to evaluate the photosensitizing properties of biopterins (such as Bip, Fop and Cap) . Pterin causes a photosensitive reaction of dGMP under UV-A radiation, causing damage to DNA molecules. There are two main mechanisms for the photosensitive oxidation of purine nucleotides by pterin in vitro: one is the hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism), and the other is the interaction between dGMP and pterin. The reaction produces singlet molecular oxygen (1O2) (Type II mechanism) .
Cat. No.: HY-183490
CAS No.: 1263402-76-1
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Glucokinase activator 11 is a substituted benzamide derivative and glucokinase activator. Glucokinase activator 11 can be used for the research of type ii diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
