170686-10-9
170686-10-9
Chemical Structure
BMS-196085
- CAS No.: 170686-10-9
- Formula:C24H26F2N2O5S
- Molecular Weight:492.54
IUPAC Name: N-(5-((R)-2-(((R)-1-(4-(difluoromethoxy)phenyl)-2-phenylethyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide
InChIKey: XWLVOJZVWRCRMD-OFNKIYASSA-N
SMILES: O[C@H](C1=CC(NS(C)(=O)=O)=C(C=C1)O)CN[C@@H](C2=CC=C(C=C2)OC(F)F)CC3=CC=CC=C3
Biological Activity: BMS-196085 is an orally active, potent and selective full agonist against human β3 adrenergic receptor with a Ki value of 21 nM. BMS-196085 also has partial agonist activity at the β1 receptor. BMS-196085 is promising for research of obesity and type-II diabetes[1][2].
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BMS-196085 | BMS-196085 is an orally active, potent and selective full agonist against human β3 adrenergic receptor with a Ki value of 21 nM. BMS-196085 also has partial agonist activity at the β1 receptor. BMS-196085 is promising for research of obesity and type-II diabetes. | |||||||||||||||||||||
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References
- [1]. Gavai A V, et al. BMS-196085: a potent and selective full agonist of the human β3 adrenergic receptor[J]. Bioorganic & medicinal chemistry letters, 2001, 11(23): 3041-3044.
- [2]. Hu B, et al. Orally bioavailable β3-adrenergic receptor agonists as potential therapeutic agents for obesityand type-II diabetes[J]. Progress in medicinal chemistry, 2003, 41: 167-194.
