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Pathways Recommended:	Stem Cell/Wnt

Results for "

Wnt/LRP5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Wnt (5) Apoptosis (1) c-Myc (1) Casein Kinase (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (1) Metabolic Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Targets Recommended: Wnt

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125146

BMD4503-2	Wnt	Others
BMD4503-2 is a quinoxaline derivative with inhibitory activity against *LRP5/6-sclerostin* interactions. BMD4503-2 restores the activity of the Wnt/β-catenin signaling pathway by competitively binding to the *LRP5/6-sclerostin* complex. BMD4503-2 can be used in the study of Wnt signaling pathways in bone development, maintenance and osteoporosis .

HY-169508

BMD4503-1	Wnt	Others
BMD4503-1 is a quinoxaline derivative. BMD4503-1 can inhibit the *LRP5/6-Sclerostin* interaction and regulate the *Wnt* signaling pathway .

HY-P991569

PF-04840082	Wnt	Metabolic Disease Endocrinology
PF-04840082 is a humanized IgG2 monoclonal antibody inhibitor targeting Dkk-1. PF-04840082 binds the physiological antagonist (Dkk-1) of the Wnt/LRP5 signal pathway and increases bone mass and bone mass density by activating osteoblasts. PF-04840082 can be used for osteoporosis research .

HY-E70390

C1s Enzyme masp-2, c1 esterase, c1-esterase	Wnt	Cardiovascular Disease Inflammation/Immunology
C1s Enzyme is a subunit of the complement C1 complex, which activates the complement as a serine protease. C1s Enzyme cleaves LRP5 and LRP6, and thus activates the *Wnt/β-Catenin* signaling pathway. C1s Enzyme promotes the macrophage M2 polarization and inhibits M1 polarization. C1s Enzyme enhances efferocytosis, exhibits anti-inflammatory activity .

HY-181930

TNIK-IN-10	Wnt c-Myc Apoptosis	Cancer
TNIK-IN-10 (Compound N15) is a TNIK inhibitor with an IC₅₀ of 0.49 nM against human TNIK. TNIK-IN-10 inhibits the enzymatic activity of TNIK, downregulates the expression of *Wnt* pathway target genes c-Myc and AXIN2, and reduces the protein expression of *LRP5* and *LRP6. TNIK-IN-10 induces apoptosis*. TNIK-IN-10 exhibits anticancer activity against colorectal cancer. TNIK-IN-10 can be used in the research of colorectal cancer .

HY-181585

FP1-24	Casein Kinase	Others
FP1-24 is a non-selective CK1 kinase inhibitor, with IC₅₀ values of 40 nM, 10 nM, 10 nM, and 40 nM against human CK1γ1, CK1γ2, CK1γ3 and CK1δ, respectively. FP1-24 exerts its activity by reducing the phosphorylation level of LRP5/6 at the T1479 site during WNT signaling pathway activation. The non-specific binding of FP1-24 to multiple kinases can be used for biological studies of specific CK1γ .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991569

PF-04840082	Wnt	Metabolic Disease Endocrinology
PF-04840082 is a humanized IgG2 monoclonal antibody inhibitor targeting Dkk-1. PF-04840082 binds the physiological antagonist (Dkk-1) of the Wnt/LRP5 signal pathway and increases bone mass and bone mass density by activating osteoblasts. PF-04840082 can be used for osteoporosis research .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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