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Results for "

antimalarial properties

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Antibiotic (2) Apoptosis (8) Autophagy (7) Bacterial (6) Calcium Channel (2) Caspase (4) Cholinesterase (ChE) (1) Endogenous Metabolite (4) Environmental Pollutants (1) FKBP (2) Fungal (5) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) HIV (3) Interleukin Related (2) Isotope-Labeled Compounds (1) MDM-2/p53 (2) Mitophagy (3) mTOR (1) NF-κB (6) NO Synthase (2) p38 MAPK (1) Parasite (23) Phosphatase (1) Phosphorylase (1) Potassium Channel (2) RANKL/RANK (2) Reference Standards (5) TNF Receptor (2) Topoisomerase (4) Wnt (2) β-catenin (1)
By Research Areas:	Cancer (12) Infection (21) Inflammation/Immunology (15) Metabolic Disease (2) Neurological Disease (6)

By Targets:

AMPK (1)

Antibiotic (2)

Apoptosis (8)

Autophagy (7)

Bacterial (6)

Calcium Channel (2)

Caspase (4)

Cholinesterase (ChE) (1)

Endogenous Metabolite (4)

Environmental Pollutants (1)

FKBP (2)

Fungal (5)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (1)

HIV (3)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

MDM-2/p53 (2)

Mitophagy (3)

mTOR (1)

NF-κB (6)

NO Synthase (2)

p38 MAPK (1)

Parasite (23)

Phosphatase (1)

Phosphorylase (1)

Potassium Channel (2)

RANKL/RANK (2)

Reference Standards (5)

TNF Receptor (2)

Topoisomerase (4)

Wnt (2)

β-catenin (1)

By Research Areas:

Cancer (12)

Infection (21)

Inflammation/Immunology (15)

Metabolic Disease (2)

Neurological Disease (6)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10529

Betulinic acid Maximum Cited Publications 35 Publications Verification Lupatic acid; Betulic acid	Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier .

HY-100711

Prodigiosin 3 Publications Verification Prodigiosine; NSC47147	Bacterial Apoptosis Wnt Fungal Parasite	Infection Inflammation/Immunology Cancer
Prodigiosin (Prodigiosine) is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin is a potent inhibitor of the Wnt/β-catenin pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-13557

Ascomycin 5+ Cited Publications Immunomycin; FR-900520; FK520	FKBP Parasite Fungal Antibiotic	Infection Neurological Disease Inflammation/Immunology
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .

HY-B1467

Domiphen bromide 1 Publications Verification	Potassium Channel Bacterial Parasite Phosphatase	Infection Inflammation/Immunology
Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC₅₀: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers .

HY-Y0152

Cinchonine 5 Publications Verification (8R,9S)-Cinchonine; LA40221	Apoptosis Parasite Autophagy Caspase Calcium Channel	Others Inflammation/Immunology Cancer
Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .

HY-Y0148

10-Hydroxydecanoic acid NSC 15139; 10-HDAA	Parasite Autophagy NF-κB Interleukin Related NO Synthase MDM-2/p53 TNF Receptor RANKL/RANK Caspase	Infection Neurological Disease Inflammation/Immunology
10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells .

HY-79504

Ferrocene	Environmental Pollutants Parasite	Infection Cancer
Ferrocene is an important structural core in bioorganometallic chemistry because of its inherent stability, excellent redox properties, and low toxicity. Ferrocene has antimalarial and anticancer properties .

HY-P3914

Cecropin A (1-7)-Melittin A (2-9) Oct-CA(1-7)M(2-9)	Bacterial	Infection
Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial activity, without the adverse hemolytic properties of bee venom peptides .

HY-10529R

Betulinic acid (Standard) Lupatic acid (Standard); Betulic acid (Standard)	Reference Standards Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite	Infection Inflammation/Immunology Cancer
Betulinic acid (Standard) is the analytical standard of Betulinic acid. This product is intended for research and analytical applications. Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier.

HY-121002

Alstonine	Parasite	Infection Neurological Disease Cancer
Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties .

HY-100711A

Prodigiosin hydrochloride 3 Publications Verification Prodigiosine hydrochloride	Bacterial Apoptosis Fungal Wnt Parasite	Infection Inflammation/Immunology Cancer
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-W744739

Betulinic acid-d3 Lupatic acid-d₃; Betulic acid-d₃	Isotope-Labeled Compounds Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite	Infection Inflammation/Immunology Cancer
Betulinic acid-d₃ (Lupatic acid-d₃) is a deuterium labeled Betulinic acid (HY-10529). Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier.

HY-13557R

Ascomycin (Standard) Immunomycin (Standard); FR-900520 (Standard); FK520 (Standard)	Reference Standards FKBP Parasite Fungal Antibiotic	Infection Neurological Disease Inflammation/Immunology
Ascomycin (Standard) is the analytical standard of Ascomycin. This product is intended for research and analytical applications. Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].

HY-Y0152R

Cinchonine (Standard) (8R,9S)-Cinchonine (Standard); LA40221 (Standard)	Reference Standards Apoptosis Parasite Autophagy Caspase Calcium Channel	Others Inflammation/Immunology Cancer
Cinchonine (Standard) is the analytical standard of Cinchonine. This product is intended for research and analytical applications. Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .

HY-N15562

Batzelladine L	Parasite	Infection
Batzelladine L is a potent *Plasmodium falciparum* inhibitor (IC₅₀= 0.4 μM). Batzelladine L shows moderate cytotoxicity to HepG2 cells (CC₅₀= 14 μM) with antimalarial properties. Batzelladine L is promising for research of antimalarial agents .

HY-121804

SSJ-183	Parasite	Others
SSJ-183 is a compound with antimalarial activity, with activity that modulates antimalarial effects and pharmacokinetic properties. SSJ-183 has shown some activity in antimalarial studies, and its pharmacokinetic properties are between those of other tested compounds, which is of certain significance for the study of new antimalarial combination therapies.

HY-151965

Antimalarial agent 18	Parasite	Infection
Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC₅₀=50 nM) and A. baumanii (IC₅₀=390 nM) .

HY-121575

Lythridine Sinine	Others	Metabolic Disease
Lythridine is a biphenyl quinolizidine lactone alkaloid originally isolated from Fraxinus sinica that has antimalarial properties. It has also been found in H. salicifolia.

HY-N7190

Yadanzioside F	Parasite	Cancer
Yadanzioside F is one of the toxic components found in Brucea javanica . Brucea javanica has demonstrated a variety of antitumoral, antimalarial, and anti-inflammatory properties .

HY-169099

Antiproliferative agent-56	Parasite	Infection
Antiproliferative agent-56 (Compound 31) is an antimalarial agent, that inhibits Plasmodium falciparum 3D7 (Pf3D7) with an IC₅₀ >12.5 (48h) and 0.03 μM (98h), and reveals a slow-acting property .

HY-175215

PfPK6-IN-1	Parasite	Infection
PfPK6-IN-1 is a potent and selective PfPK6 inhibitor with an IC₅₀ of 0.3 μM. PfPK6-IN-1 inhibits hemozoin formation, a Plasmodium-specific pathway with IC₅₀ of 13 μM against β-hematin (βH). PfPK6-IN-1 exhibits rapid and broad-spectrum anti-malarial properties, being effective against both chloroquine-sensitive and resistant strains.PfPK6-IN-1 can be used for the study of antimalarial .

HY-B1467R

Domiphen bromide (Standard)	Reference Standards Potassium Channel Bacterial Parasite Phosphorylase	Infection Inflammation/Immunology
Domiphen bromide (Standard) is the analytical standard of Domiphen bromide (HY-B1467). This product is intended for research and analytical applications. Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC₅₀: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers.

HY-Y0148R

10-Hydroxydecanoic acid (Standard) NSC 15139 (Standard); 10-HDAA (Standard)	Reference Standards Parasite Autophagy NF-κB Interleukin Related NO Synthase MDM-2/p53 TNF Receptor RANKL/RANK Caspase	Infection Neurological Disease Inflammation/Immunology
10-Hydroxydecanoic acid (Standard) is the analytical standard of 10-Hydroxydecanoic acid. This product is intended for research and analytical applications. 10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells[1][2][3][4][5].

HY-N12609

3β-Isodihydrocadambine	Endogenous Metabolite	Inflammation/Immunology
3β-Isodihydrocadambine, a derivative of cadambine, is obtained from the bark and leaves of Neolamarckia cadamba and possesses notable antimalarial, antiproliferative, antioxidant, anticancer, and anti-inflammatory properties.

HY-181010

HDAC1-IN-12	HDAC Parasite	Infection
HDAC1-IN-12 is a Plasmodium falciparum HDAC1 (PfHDAC1) inhibitor with an IC₅₀ of 4.1 nM against Pf3D7. HDAC1-IN-12 inhibits PfHDAC1, upregulates histone H₃ acetylation in P. falciparum parasites, downregulates malaria invasion-related gene expression, and exhibits favorable safety profiles, improved physicochemical properties, and potent in vivo antimalarial activity. HDAC1-IN-12 can be used for the research of malaria .

HY-178724

Mollicellin K	Fungal Bacterial Parasite	Infection Cancer
Mollicellin K is a depsidone that can be isolated from the fungus Chaetomium brasiliense. Mollicellin K exhibits antimicrobial activity against Myobacterium tuberculosis, antimalarial activity (IC₅₀ = 1.2 μM) against Plasmodium falciparum as well as antifungal property (IC₅₀ = 1.2 μM) against Candida albicans. Mollicellin K is cytotoxic against KB (IC₅₀ = 1.9 μM), BC1 (IC₅₀ = 6.8 μM), NCI-H187 (IC₅₀ = 0.35 μM), and five cholangiocarcinoma cell lines. Mollicellin K also has an MIC of 12.5 μM for tuberculosis .

HY-W800535

Cryptolepine	NF-κB p38 MAPK mTOR Topoisomerase AMPK Apoptosis Cholinesterase (ChE) HIF/HIF Prolyl-Hydroxylase β-catenin	Infection Metabolic Disease Inflammation/Immunology Cancer
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. Cryptolepine acts as an inhibitor of c-Myc, mTOR, NF-κB, HIF-1, MAPK and an activator of AMPKα1/2. It intercalates into DNA, inhibits topoisomerase II (Top II), disrupts mitochondrial dynamics and induces apoptosis. Cryptolepine also exhibits anti-plasmodial and cholinesterase inhibitory activities. Cryptolepine can be used in research related to tumors (melanoma, hepatocellular carcinoma, mammary adenocarcinoma, etc.), malaria, inflammatory diseases and diabetes, particularly in studies focused on inhibiting tumor growth and anti-plasmodial infection .

Cat. No.	Product Name	Target	Research Area