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Results for "

cross-linker

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA Alkylator/Crosslinker (44) ADC Linker (19) ADC Payload (9) Amino Acid Derivatives (6) Anion Exchangers (1) Antibiotic (10) Apoptosis (20) Autophagy (1) Bacterial (16) Bcl-2 Family (2) Beta-lactamase (3) Biochemical Assay Reagents (272) Calcium Channel (1) Carboxylesterase (CES) (3) Casein Kinase (1) Caspase (4) CD19 (1) CD3 (1) CFTR (1) Cholinesterase (ChE) (3) Collagen (1) CXCR (1) Cytochrome P450 (1) Discoidin Domain Receptor (1) DNA/RNA Synthesis (4) Drug Derivative (3) Drug Intermediate (4) Drug Metabolite (1) Drug-Linker Conjugates for ADC (4) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (3) EAAT (1) EGFR (1) Endogenous Metabolite (10) Environmental Pollutants (6) Epigenetic Reader Domain (1) Eukaryotic Initiation Factor (eIF) (1) FAK (1) Ferroptosis (1) FKBP (2) Fluorescent Dye (11) Fructose-1,6-bisphosphate aldolase (1) Glutaminase (1) Glutathione Peroxidase (1) Glycosidase (2) Guanylate Cyclase (1) Integrin (1) Isotope-Labeled Compounds (13) Liposome (3) Lipoxygenase (2) Lysyl Oxidase (1) MDM-2/p53 (2) Microtubule/Tubulin (1) MMP (2) MOFs (2) Monoamine Oxidase (2) P2Y Receptor (2) Parasite (1) PD-1/PD-L1 (1) Penicillin-binding protein (PBP) (1) Peptide-Drug Conjugates (PDCs) (1) Potassium Channel (3) PROTAC Linkers (15) Pyroptosis (1) Reactive Oxygen Species (ROS) (3) Reference Standards (16) Ser/Thr Protease (1) SOD (1) Sodium Channel (3) TNF Receptor (2) Topoisomerase (3) VSV (1)
By Research Areas:	Cancer (98) Cardiovascular Disease (9) Endocrinology (3) Infection (19) Inflammation/Immunology (32) Metabolic Disease (13) Neurological Disease (13)
Click Chemistry:	ADC Synthesis (2) Labeling and Fluorescence Imaging (1) DBCO (1) PROTAC Synthesis (3) BCN (2) Azide (10) Alkynes (2)
Oligonucleotides:	Pegylated Lipids (3) Polymers (5)

453

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

217

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: DNA Alkylator/Crosslinker

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W019543

Disuccinimidyl suberate Crosslinker 10+ Cited Publications	Biochemical Assay Reagents	Cancer
Disuccinimidyl suberate Crosslinker is an amine-reactive bifunctional protein crosslinker. Disuccinimidyl suberate Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-124329

BS3 Crosslinker 1 Publications Verification	Biochemical Assay Reagents	Cancer
BS3 Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-114697

DSG Crosslinker 4 Publications Verification Disuccinimidyl glutarate	Biochemical Assay Reagents	Inflammation/Immunology
DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-118759

DSP Crosslinker 2 Publications Verification	Biochemical Assay Reagents	Inflammation/Immunology
DSP Crosslinker is an amine-reactive and cleavable protein crosslinker. DSP Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-124329A

*BS3 Crosslinker* disodium** 1 Publications Verification	Biochemical Assay Reagents	Cancer
BS3 Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-137383

Sulfo-SANPAH	Biochemical Assay Reagents Reactive Oxygen Species (ROS)	Others
Sulfo-SANPAH is a primary amine-nitrobenzene azide cross-linker. Sulfo-SANPAH improves the functionalization process of PDMS surfaces, is covalently bound to the PAAm gel surface. Sulfo-SANPAH is widely used to crosslink ECM proteins to various substrates, including acrylic-based hydrogels, such as polyacrylamide hydrogels. Sulfo-SANPAH facilitates covalent binding through its negatively charged sulfonate group on its N-hydroxysuccinimide ester ring and a photoactivated phenyl azide group that is highly reactive with nucleophiles and free radicals .

HY-126349

DTSSP Crosslinker	ADC Linker	Others
DTSSP Crosslinker is a crosslinker reactive with primary amines. DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-100216

SPDP 5 Publications Verification SPDP crosslinker; Py-ds-Prp-OSu	ADC Linker	Cancer
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) .

HY-130458

EGNHS 5 Publications Verification EGS crosslinker	PROTAC Linkers	Cancer
EGNHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-130435

DBCO-PEG4-amine	ADC Linker PROTAC Linkers	Cancer
DBCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker) . DBCO-PEG4-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-157414

Azide-A-DSBSO crosslinker	Biochemical Assay Reagents	Others
Azide-A-DSBSO crosslinker is a mass spectrometry (MS) cleavable, membrane permeable, homobifunctional, azide-labeled, acid-cleavable crosslinking peptide. Azide-A-DSBSO crosslinker crosslinks proteins via NHS ester reaction with lysine residues. Azide-A-DSBSO crosslinker can be used to study protein-protein interactions by cross-linking mass spectrometry (XL-MS) ^{[1] .}

HY-W011541

SIA Crosslinker Iodoacetic acid N-hydroxysuccinimide ester; N-Succinimidyl Iodoacetate	ADC Linker	Cancer
SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-111434A

N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride UAA crosslinker 1 hydrochloride	Amino Acid Derivatives	Cancer
N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride (UAA crosslinker 1 hydrochloride) is a click chemistry-reactive amino acid derivative. N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride mediates the generation of antibody-drug conjugates (ADCs). N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride is used for site-specific incorporation into recombinant proteins, or for synthesizing chemical probes and tools for biological research .

HY-P3159

VPM peptide	Biochemical Assay Reagents	Others
VPM peptide is a dithiol protease-cleavable peptide cross-linker. VPM peptide can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel .

HY-148140

Cross-linked dextran G 25 1 Publications Verification	Biochemical Assay Reagents	Others
Cross-linked dextran G 25 is a dextran chromatography medium. Cross-linked dextran G 25 separates from 1 to 5 kD (spherical proteins) and can be used for the separation of peptides as well as for the desalting and buffer replacement of large molecule proteins .

HY-124318

SMPH Crosslinker	PROTAC Linkers	Cancer
SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-168937

HS-PEG2000-NH2 hydrochloride	PROTAC Linkers	Others
HS-PEG2000-NH2 hydrochloride is a bifunctional cross-linker that can be used to synthesize PEG hydrogels .

HY-111434

N6-[(2-Azidoethoxy)carbonyl]-L-lysine UAA crosslinker 1	Amino Acid Derivatives	Cancer
N6-[(2-Azidoethoxy) carbonyl]-L-lysine (UAA crosslinker 1) is a click chemistry-reactive amino acid derivative. N6-[(2-Azidoethoxy) carbonyl]-L-lysine mediates the generation of antibody-drug conjugates (ADCs). N6-[(2-Azidoethoxy) carbonyl]-L-lysine is used for site-specific incorporation into recombinant proteins, or for synthesizing chemical probes and tools for biological research .

HY-113033

Pentosidine	Others Biochemical Assay Reagents	Neurological Disease Metabolic Disease Inflammation/Immunology
Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins . Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases .

HY-156045C

Cross-linked dextran G 200	Biochemical Assay Reagents	Others
Cross-linked dextran G 200 is a hydrophilic gel based on molecular size exclusion and targeted macromolecular separation. Cross-linked dextran G 200 works through the gel permeation mechanism, and the cross-linked structure forms a three-dimensional network with a specific pore size, achieving separation based on the molecular hydrodynamic volume. Cross-linked dextran G 200 can be used to adjust the osmotic solute distribution coefficient and the ability to maintain osmotic equilibrium, such as in gel filtration chromatography for purification and analysis of biomacromolecules such as proteins and nucleic acids . Cross-linked dextran G 200 can also be used as a gel filtration filler (particle size range: 40-120 μm; globular protein separation range: 5-600 kDa) .

HY-W017588

N-(2-Hydroxyethyl)maleimide	Biochemical Assay Reagents	Others
N-(2-Hydroxyethyl)maleimide is a cross-linker. N-(2-Hydroxyethyl)maleimide is used for chemical synthesis .

HY-134853

2-(Boc-amino)ethanethiol	Biochemical Assay Reagents	Cancer
2-(Boc-amino)ethanethiol (compound 35) is a bifunctional cross-linker that can be used in the synthesis of bifunctional azobenzene glycoconjugates .

HY-120937

DC4 Crosslinker	Biochemical Assay Reagents	Others
DC4 Crosslinker is a stable crosslinking reagent with improved activity and solubility. DC4 Crosslinker is labile cleavable with collision-induced dissociation (CID), that will be fragmented into four rearrange products containing mobilized protons .

HY-145485

HS-PEG3400-SH	PROTAC Linkers	Others
HS-PEG3400-SH, a linear homobifunctional PEG, is a cross-linker. HS-PEG-SH can be used for drug delivery and preparation of PEG hydrogels .

HY-103703

*DEAE Cross-linked dextran A 25*	Anion Exchangers	Metabolic Disease Inflammation/Immunology
DEAE Cross-linked dextran A 25 is a weak anion exchange chromatography packing material. DEAE Cross-linked dextran A 25 can be used for the analysis of trace metal humic acid complexes in river water and the purification of biomacromolecules. DEAE Cross-linked dextran A 25 can also be used for research on diseases related to abnormal AVP levels .

HY-156045B

Cross-linked dextran G 150	Biochemical Assay Reagents	Others
Cross-linked dextran G 150 is a hydrophilic gel based on molecular size exclusion and targeted for the separation of macromolecules. Cross-linked dextran G 150 functions through the gel permeation mechanism, where the cross-linked structure forms a three-dimensional network with specific pore diameters, achieving separation based on the molecular volumetric flow. Cross-linked dextran G 150 can be used to regulate the distribution coefficient of permeating solutes and maintain the permeation balance, such as in gel filtration chromatography for the purification and analysis of biological macromolecules like proteins and nucleic acids. Cross-linked dextran G 150 can also be used as a gel filtration filler (particle size range: 40-120 μm; spherical protein separation range: 5-300 kDa) .

HY-W096122

*DTSSP Crosslinker* disodium**	Biochemical Assay Reagents	Others
DTSSP Crosslinker disodium is a protein cross-linker containing a disulfide bond. DTSSP Crosslinker disodium can react with sidechains of amino acids that are within close proximity .

HY-168940

NH2-PEG1100-COOH	Biochemical Assay Reagents	Others
NH2-PEG-COOH (Mn 1100) is a bifunctional cross-linker that can be used to synthesize PEG hydrogels .

HY-W1049061

Boc-NH-PEG2000-COOH	Biochemical Assay Reagents	Others
Boc-NH-PEG2000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG2000-COOH is an important cross-linker with PEG chains .

HY-140232B

BOC-NH-PEG2000-NH2	Biochemical Assay Reagents	Others
BOC-NH-PEG2000-NH2 is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG2000-NH2 is an important cross-linker with PEG chains .

HY-164068

Cross-linked sodium hyaluronate gel	Biochemical Assay Reagents	Others Inflammation/Immunology
Cross-linked sodium hyaluronate gel is a biomaterial formed by cross-linking sodium hyaluronate. Cross-linked sodium hyaluronate gel has good moisturizing properties, viscoelasticity and biocompatibility. Cross-linked sodium hyaluronate gel can be used for the treatment of arthritis and the development of auxiliary materials in ophthalmic surgery .

HY-159008

NHSF	Biochemical Assay Reagents	Others
NHSF is a protein cross-linking agent .

HY-W123009

Sulfo-KMUS sodium salt 11-Maleimidoundecanoic acid sulfo-N-succinimidyl ester sodium salt	Biochemical Assay Reagents	Others
Sulfo-KMUS (sodium salt) acts as a crosslinker .

HY-168937D

HS-PEG3500-NH2 hydrochloride	PROTAC Linkers	Others
HS-PEG-NH2 (Mn 3500) hydrochloride is a bifunctional cross-linker that can be used to synthesize PEG hydrogels .

HY-23497

Poly(4-vinylphenol)	Others	Others
Poly(4-vinylphenol) is a polymer cross-linking agent that can be used to prepare non-toxic films. Poly(4-vinylphenol) is a sensitizer of titania for visible light photocatalysis. Poly(4-vinylphenol) also can be used as a water resistive wood adhesive, as a gate dielectric insulator in organic field effect transistors, and as a responsive surface coating .

HY-147116

4-[3-(Trifluoromethyl)diazirin-3-yl] benzoic acid N-hydroxysuccinimide ester	Biochemical Assay Reagents	Others
4-[3-(Trifluoromethyl)diazirin-3-yl] benzoic acid N-hydroxysuccinimide ester is a photoactivated bifunctional cross-linker. 4-[3-(Trifluoromethyl)diazirin-3-yl] benzoic acid N-hydroxysuccinimide ester can be used for researching a strategy of rapid and accurate structure generation in support of antigen engineering programs .

HY-W1048572D

N3-PEG3400-NH2 Azide-PEG3400-Amine	PROTAC Linkers	Others
N3-PEG3400-NH2 (Azide-PEG3400-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG3400-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .

HY-130547A

BS2G Crosslinker	DNA Alkylator/Crosslinker	Cancer
BS2G Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS2G Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-130547

*BS2G Crosslinker* disodium**	DNA Alkylator/Crosslinker	Cancer
BS2G Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS2G Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-119523

Disuccinimidyl sebacate 2 Publications Verification DSSeb; Sebacic acid bis N-succinimidyl ester	Biochemical Assay Reagents	Others
Disuccinimidyl sebacate (DSSeb) is a cross-linker that can be used in the synthesis of the intermolecular cross-linked peptides .

HY-168940A

NH2-PEG3500-COOH	Biochemical Assay Reagents	Others
NH2-PEG-COOH (Mn 3500) is a bifunctional cross-linker that can be used to synthesize PEG hydrogels .

HY-130601

Thiol-PEG5-thiol Bis-PEG5-thiol	Biochemical Assay Reagents	Others
Thiol-PEG5-thiol (Bis-PEG5-thiol) is a bifunctional thiol cross-linker agent.

HY-140232D

BOC-NH-PEG5000-NH2	Biochemical Assay Reagents	Others
BOC-NH-PEG5000-NH2 is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG5000-NH2 is an important cross-linker with PEG chains .

HY-P10765

DTS-108	Peptide-Drug Conjugates (PDCs) Topoisomerase	Cancer
DTS-108 is a prodrug of SN38 (HY-13704) (a Topoisomerase I inhibitor). DTS-108 is a conjugate generated by linking SN38 to a human oligopeptide via an esterase sensitive cross-linker. DTS-108 exhibits anti-tumor activity against colorectal, lung, and mammary cancer .

HY-W1048555B

Mal-PEG3400-SCM	Biochemical Assay Reagents	Others
Mal-PEG3400-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG3400-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .

HY-W1048572C

N3-PEG1000-NH2 Azide-PEG1000-Amine	Biochemical Assay Reagents	Others
N3-PEG1000-NH2 (Azide-PEG1000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG1000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .

HY-149872

DCA-RMR1	Biochemical Assay Reagents	Others
DCA-RMR1 is a cross-linker. DCA-RMR1 elicits facile bicyclization of native peptides via N-terminus Cys-Cys cross-linking. DCA-RMR1 derivatizes RMR1 with 1,3-dichloroacetone (DCA) .

HY-144337

*DNA crosslinker* 4 dihydrochloride**	DNA Alkylator/Crosslinker	Cancer
DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer .

HY-144335

*DNA crosslinker* 2 dihydrochloride**	DNA Alkylator/Crosslinker	Cancer
DNA crosslinker 2 (dihydrochloride) is a potent DNA minor groove binder with DNA binding affinity (ΔT_m) of 1.2 °C. DNA crosslinker 2 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 2 (dihydrochloride) can be used for researching anticancer .

HY-144336

*DNA crosslinker* 3 dihydrochloride**	DNA Alkylator/Crosslinker	Cancer
DNA crosslinker 3 (dihydrochloride) (compound 1) is a potent DNA minor groove binder with DNA binding affinity (ΔT_m) of 1.4 °C. DNA crosslinker 3 (dihydrochloride) can be used for researching anticancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-129630

Tetrahydrocortisol	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Microtubule/Tubulin
Tetrahydrocortisol is a cortisol metabolite that inhibits dexamethasone-induced formation of cross-linked actin networks. Tetrahydrocortisol can be used in the research of primary open-angle glaucoma, glucocorticoid-induced ocular hypertension, Lewis lung carcinoma, and EMT-6 mouse breast cancer .

HY-129380

Fructosyl-lysine 1 Publications Verification Fructoselysine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes?detection .

HY-N1470

Plantagoside	Plantaginaceae Structural Classification Flavonoids Classification of Application Fields Flavonones Phenols Polyphenols Metabolic Disease Plantago asiatica L. Plants Disease Research Fields Source Classification	Glycosidase
Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC₅₀ values of 5 μM and a K_i of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .

HY-129380A

Fructosyl-lysine dihydrochloride 1 Publications Verification Fructoselysine dihydrochloride	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .

HY-113033

Pentosidine	Structural Classification Natural Products Disease markers Endogenous metabolite Source Classification	Others Biochemical Assay Reagents
Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins . Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases .

HY-23497

Poly(4-vinylphenol)	Classification of Application Fields Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Others
Poly(4-vinylphenol) is a polymer cross-linking agent that can be used to prepare non-toxic films. Poly(4-vinylphenol) is a sensitizer of titania for visible light photocatalysis. Poly(4-vinylphenol) also can be used as a water resistive wood adhesive, as a gate dielectric insulator in organic field effect transistors, and as a responsive surface coating .

HY-N16478

Echihumiline	Pyrrolizidine Alkaloids Structural Classification Alkaloids Plants Boraginaceae Echium humile Desf. Source Classification	Cytochrome P450
Echihumiline is an alkaloid targeting hepatic cytochrome P450 enzymes (CYP450). Echihumiline induces DNA cross-linking and oxidative stress in hepatocytes, leading to liver necrosis and fibrosis. Echihumiline is promising for research of liver diseases .

HY-129380AR

Fructosyl-lysine dihydrochloride (Standard) Fructoselysine dihydrochloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Fructosyl-lysine (dihydrochloride) (Standard) is the analytical standard of Fructosyl-lysine (dihydrochloride). This product is intended for research and analytical applications. Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine-arginine protein cross-link that can be an indicator in diabetes detection .

HY-162397

Neopetromin	Monophenols Microorganisms Phenols Source Classification	Others
Neopetromin is a tripeptide with a rare heteroaromatic C-N cross-link between side chains of tryptophan and tyrosine. Neopetromin causes vacuole fragmentation in an actin-independent manner .

HY-N15254

2-S-Cysteinyldopa	Structural Classification Animals Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite
2-S-Cysteinyldopa is a cross-linking compound that can be isolated from the byssal threads of P. canaliculus. 2-S-Cysteinyldopa also can be formed by oxidation of pcfp-1 in vitro using mushroom tyrosinase .

HY-N1470R

Plantagoside (Standard)	Plantaginaceae Structural Classification Flavonoids Flavonones Phenols Polyphenols Plantago asiatica L. Plants Source Classification	Reference Standards Glycosidase
Plantagoside (Standard) is the analytical standard of Plantagoside (HY-N1470). This product is intended for research and analytical applications. Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC₅₀ values of 5 μM and a K_i of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .

Cat. No.	Product Name	Chemical Structure

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-129630S

Tetrahydrocortisol-d5
Tetrahydrocortisol-d₅ is the deuterium labeled Tetrahydrocortisol. Tetrahydrocortisol is a cortisol metabolite that inhibits dexamethasone-induced formation of cross-linked actin networks. Tetrahydrocortisol can be used in the research of primary open-angle glaucoma, glucocorticoid-induced ocular hypertension, Lewis lung carcinoma, and EMT-6 mouse breast cancer .

HY-118759S

*DSP Crosslinker-d8*
DSP Crosslinker-d₈ is the deuterium labeled DSP Crosslinker (HY-118759). DSP Crosslinker is an amine-reactive and cleavable protein crosslinker. DSP Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-W705390

*Disuccinimidyl suberate Crosslinker-d4*
Disuccinimidyl suberate Crosslinker-d₄ is the deuterium labeled Disuccinimidyl suberate Crosslinker (HY-W019543). Disuccinimidyl suberate Crosslinker is an amine-reactive bifunctional protein crosslinker. Disuccinimidyl suberate Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-114697S

*DSG Crosslinker-d4*
DSG Crosslinker-d₄ (Disuccinimidyl glutarate-d₄) is the deuterium labeled DSG Crosslinker (HY-114697). DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-13567S

Bendamustine-d4
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-B0077S1

Bendamustine-d8 hydrochloride
Bendamustine-d₈ (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-13567S1

Bendamustine-d8
Bendamustine-d₈ is the deuterium labeled Bendamustine . Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

HY-136610S

Chlorpyrifos-oxon-d10
Chlorpyrifos-oxon-d₁₀ is the deuterium labeled Chlorpyrifos-oxon. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function .

HY-W738282

Bendamustine-d7 hydrochloride
Bendamustine-d₇ hydrochloride (SDX-105-d₇) is the deuterium labeled Bendamustine hydrochloride (HY-B0077). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-W701476

Ethyl phenylglyoxylate-d5

Ethyl phenylglyoxylate-d₅ (Ethyl benzoylformate-d₅; Phenylglyoxylic acid ethyl ester-d₅) is the deuterium labeled Ethyl phenylglyoxylate (HY-W016618). Ethyl phenylglyoxylate (Ethyl benzoylformate), the ethyl ester of phenylglyoxylic acid, is used as a synthetic reagent. Ethyl phenylglyoxylate is also a poor substrate but a potent inhibitor of chicken liver carboxylesterase. Additionally, Ethyl phenylglyoxylate exhibits photoreactivity, where its excited triplet carbonyl can initiate intermolecular hydrogen abstraction, radical coupling and cross-linking reactions .

HY-W710827

N,N'-Methylenebisacrylamide-d6

N,N'-Methylenebisacrylamide-d₆ is the deuterium labeled N,N'-Methylenebisacrylamide (HY-D0848). N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel .

HY-78985S

Benzene-1,3,5-tricarboxylic acid-d3

Benzene-1,3,5-tricarboxylic acid-d₃ (Trimesic acid-d₃) is the deuterium labeled Benzene-1,3,5-tricarboxylic acid (HY-78985). Benzene-1,3,5-tricarboxylic acid (Trimesic acid) is a rigid planar small-molecule scaffold and crosslinker. Benzene-1,3,5-tricarboxylic acid induces bicyclic peptides to adopt a planar conformation, so as to maximize surface area and bind to the flat protein surfaces involved in protein-protein interactions. Benzene-1,3,5-tricarboxylic acid forms ionic crosslinks, hydrogen bonds and π-π bonds with chitosan, thereby constructing a hydrogel network. Benzene-1,3,5-tricarboxylic acid endows chitosan hydrogel systems with specific mechanical properties, enabling sustained release of cancer therapeutic drugs including 5-Fluorouracil (HY-90006) .

HY-124329AS

*BS3 Crosslinker-d4 disodium*
BS3 Crosslinker-d₄ disodium is the deuterium labeled BS3 Crosslinker. BS3 Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-130547S

*BS2G Crosslinker-d4 disodium*
BS2G Crosslinker-d₄ disodium is the deuterium labeled BS2G Crosslinker disodium (HY-130547). BS2G Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS2G Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-16046S

Rimiducid-d4
Rimiducid-d₄ (AP1903-d₄) is the deuterium labeled Rimiducid (HY-16046). Rimiducid (AP1903) is a dimerizer agent that acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.

Targets Recommended: DNA Alkylator/Crosslinker

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-42360G

SMCC	ADC Linker	Inflammation/Immunology Cancer
SMCC (GMP) is the GMP level of SMCC (HY-42360). GMP guidelines are used to produce SMCC (HY-42360) (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. SMCC (GMP) is a protein crosslinker. SMCC (GMP) contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.

HY-128952G

Tesirine SG3249	Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker	Cancer
Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .

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