82436-77-9
Chemical Structure
BS3 Crosslinker
- CAS No.: 82436-77-9
- Formula:C16H20N2O14S2
- Molecular Weight:528.47
IUPAC Name: 1,1'-(octanedioylbis(oxy))bis(2,5-dioxopyrrolidine-3-sulfonic acid)
InChIKey: VYLDEYYOISNGST-UHFFFAOYSA-N
SMILES: O=C(CCCCCCC(ON1C(C(CC1=O)S(=O)(O)=O)=O)=O)ON2C(C(CC2=O)S(=O)(O)=O)=O
Biological Activity: BS3 Crosslinker is a cell-impermeable NHS ester crosslinker. BS3 Crosslinker "covalently locks" two spatially adjacent proteins on the surface of living cells into a covalent complex, and the dimerization/oligomerization status is determined by observing molecular weight shifts via Western blot. BS3 Crosslinker can crosslink EGFR and c-MET to assist in detecting and evaluating their dimerization status. It can be used in research related to oral cancer and glioblastoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BS3 Crosslinker | 99.84% | BS3 Crosslinker is a cell-impermeable NHS ester crosslinker. BS3 Crosslinker "covalently locks" two spatially adjacent proteins on the surface of living cells into a covalent complex, and the dimerization/oligomerization status is determined by observing molecular weight shifts via Western blot. BS3 Crosslinker can crosslink EGFR and c-MET to assist in detecting and evaluating their dimerization status. It can be used in research related to oral cancer and glioblastoma. | ||||||||||||||||||||
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References
- [1]. Chen S, et al. LncRNA EUDAL shapes tumor cell response to hypoxia-induced constitutive EGFR activation and promotes chemoresistance in oral cancer. International journal of oral science. 2025 Sep 12;17(1):64. [Content Brief]
- [2]. Wang Y, et al. S-palmitoylation of c-MET by CK2α-mediated zDHHC15 phosphorylation drives glioblastoma stem cell tumorigenicity. Neuro-oncology. 2025 Sep 17;27(8):1972-1986. [Content Brief]
