2-(Pyridyldithio)ethylamine hydrochloride
Based on 4 publication(s) in Google Scholar
2-(Pyridyldithio)ethylamine hydrochloride is a novel disulfide intercalating cross-linking reagent.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 106139-15-5
- Formula: C7H11ClN2S2
- Molecular Weight:222.76
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 2-(Pyridyldithio)ethylamine hydrochloride
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Biological Activity
2-(Pyridyldithio)ethylamine hydrochloride can be used in the preparation of a drug-octreotide conjugate[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 106139-15-5
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Appearance Solid
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Molecular Weight 222.76
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Formula C7H11ClN2S2
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Color White to off-white
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SMILES
NCCSSC1=NC=CC=C1.[H]Cl
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Synonyms
(S)-2-Pyridylthio Cysteamine Hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Anal Chem
Thiol-Disulfide Exchange Reaction for Cellular Glutathione Detection with Surface-Enhanced Raman Scattering. [Abstract]2018 Oct 2;90(19):11333-11339. PMID: 30153733 -
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Pharmaceutics
Fluorinated Cell-Penetrating Peptide for Co-Delivering siHIF-1α and Sorafenib to Enhance In Vitro Anti-Tumor Efficacy. [Abstract]2023 Dec 16;15(12):2789. PMID: 38140129 -
Bioorg Chem
A cathepsin B/GSH dual-responsive fluorinated peptide for effective siRNA delivery to cancer cells. [Abstract]2023 Jun:135:106485. PMID: 36963370
Solvent & Solubility
H2O : 50 mg/mL (224.46 mM; Need ultrasonic)
DMSO : ≥ 32 mg/mL (143.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.22 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.22 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (448.91 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.4891 mL | 22.4457 mL | 44.8914 mL | 112.2284 mL |
| 5 mM | 0.8978 mL | 4.4891 mL | 8.9783 mL | 22.4457 mL | |
| 10 mM | 0.4489 mL | 2.2446 mL | 4.4891 mL | 11.2228 mL | |
| 15 mM | 0.2993 mL | 1.4964 mL | 2.9928 mL | 7.4819 mL | |
| 20 mM | 0.2245 mL | 1.1223 mL | 2.2446 mL | 5.6114 mL | |
| 25 mM | 0.1796 mL | 0.8978 mL | 1.7957 mL | 4.4891 mL | |
| 30 mM | 0.1496 mL | 0.7482 mL | 1.4964 mL | 3.7409 mL | |
| 40 mM | 0.1122 mL | 0.5611 mL | 1.1223 mL | 2.8057 mL | |
| 50 mM | 0.0898 mL | 0.4489 mL | 0.8978 mL | 2.2446 mL | |
| 60 mM | 0.0748 mL | 0.3741 mL | 0.7482 mL | 1.8705 mL | |
| 80 mM | 0.0561 mL | 0.2806 mL | 0.5611 mL | 1.4029 mL | |
| 100 mM | 0.0449 mL | 0.2245 mL | 0.4489 mL | 1.1223 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2-(Pyridyldithio)ethylamine hydrochloride Related Classifications
HY-101794 Related Classifications
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