54 Results for "

defensin

" in MedChemExpress (MCE) Product Catalog:
Products (54)

54 Results for "defensin" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-N7057
CAS No.: 112-05-0
Synonyms: Pelargonic acid
Nonanoic acid (Pelargonic acid) is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2 .
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1 Cited Publications
Cat. No.: HY-19892A
CAS No.: 1224095-99-1
Synonyms: PMX 30063 tetrahydrochloride
Target:  

Bacterial Antibiotic

Research Areas:  

Infection Cancer

Brilacidin tetrahydrochloride (PMX 30063 tetrahydrochloride) is an anti-infective antimicrobial with MIC90s of 1 and 8 μg/mL for Gram-positive bacteria Streptococcus pneumonia and Streptococcus viridans, and MIC90 of 8 and 4 μg/mL for Gram-negative bacteria Haemophilus influenza and Pseudomonas aeruginosa. Brilacidin tetrahydrochloride is a defensin mimetic antibiotic compound .
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1 Cited Publications
Cat. No.: HY-P72171
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DEFA1; Neutrophil defensin 1; Prev. DEFA2; defensin, Alpha 1; Prev. DEF1; HP-1; Prev. MRS; HP1; HNP-1; Myeloid-Related Sequence; defensin, Alpha 1, Myeloid-Related Sequence; defensin Alpha 1; defensin, Alpha 2
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1 Cited Publications
Cat. No.: HY-P7135
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: defensin beta 4A; Beta-defensin 2; BD-2; hBD-2; defensin; beta 2; Skin-antimicrobial peptide 1; SAP1; DEFB4A; DEFB102; DEFB2; DEFB4; DEFB4B
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Cat. No.: HY-P2310
CAS No.: 148093-65-6
Defensin HNP-1 human is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human has antileishmanial activity. Defensin HNP-1 human is involved in endothelial cell dysfunction during the early development of atherosclerosis .
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Cat. No.: HY-P2310A
Defensin HNP-1 human TFA is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human TFA possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human TFA inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human TFA has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human TFA has antileishmanial activity. Defensin HNP-1 human TFA is involved in endothelial cell dysfunction during the early development of atherosclerosis .
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Cat. No.: HY-P2315
CAS No.: 452274-53-2
Synonyms: HβD-1
Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by all epithelial surfaces, but also by circulatory cells and cells of the reproductive tract. Human β-defensin-1 has antimicrobial activities against a broad-sperm bacteria .
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Cat. No.: HY-Y0603
CAS No.: 121-71-1
Synonyms: m-Hydroxyacetophenone
3-Hydroxyacetophenone (m-Hydroxyacetophenone) is a hydroxy-substituted alkyl phenyl ketone and also a plant defensin in carnations. 3-Hydroxyacetophenone has antifusarium activity. In addition, 3-Hydroxyacetophenone can be used to synthesize Rivastigmine (HY-17368) .
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Cat. No.: HY-P2302
CAS No.: 136661-76-2
Defensin HNP-3 human is an α-defensin stored in the azurophilic granules of human neutrophils. Defensin HNP-3 human exerts broad-spectrum bactericidal, antifungal and antiviral activities mainly by forming bacterial membrane pores, and acts as a chemoattractant for monocytes and T cells. Defensin HNP-3 human maintains epithelial integrity to support periodontal tissue homeostasis, and exerts concentration-dependent effects on epithelial cell proliferation, adhesion and bacterial adhesion. Defensin HNP-3 human targets solid tumors and leukemia by inducing single-strand DNA breaks and membrane permeabilization in tumor cells via electrostatic binding and pore formation. Defensin HNP-3 human is abundant in human tongue squamous cell carcinoma and neutrophils infiltrating oral squamous cell carcinoma. Defensin HNP-3 human can be applied to research related to periodontitis and human tongue squamous cell carcinoma .
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Cat. No.: HY-N7057S
CAS No.: 130348-94-6
Synonyms: Pelargonic acid-d17
Nonanoic acid (Pelargonic acid)-d17 is the deuterium labeled Nonanoic acid (HY-N7057). Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2 .
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Cat. No.: HY-N7057S2
CAS No.: 1219795-27-3
Synonyms: Pelargonic acid-d4
Nonanoic acid (Pelargonic acid)-d4 is the deuterium labeled Nonanoic acid (HY-N7057). Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2 .
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Cat. No.: HY-P5694
Target:  

HPV Parasite

Research Areas:  

Infection

Human α-defensin 5 is an antiviral peptide. Human α-defensin 5 blocks infection of non-enveloped viruses, including AdV, HPV, and polyomaviruses (IC50: 0.6-1.25 μM for HPV16). Human α-defensin 5 can bind to the viral capsid and blocks escape of the virus from the endosome. Human α-defensin 5 increases HIV binding to the cell surface. Human α-defensin 5 also has parasiticidal activity .
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Cat. No.: HY-P5681
Target:  

Bacterial

Research Areas:  

Infection Inflammation/Immunology

Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation .
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Cat. No.: HY-P2311
CAS No.: 120721-97-3
Research Areas:  

Inflammation/Immunology

Defensin HNP-2 human is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils.
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Cat. No.: HY-P3979
Synonyms: HNP 4
Research Areas:  

Infection

Defensin HNP 4 (HNP 4) is a host-defense peptide that has antimicrobial activity against Gram-negative bacteria. Defensin HNP 4 inhibits ACTH stimulated synthesis of Corticosterone (HY-B1618) in rat adrenal cell suspensions .
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Cat. No.: HY-P10400
CAS No.: 902781-11-7
Target:  

Phytohormone

Research Areas:  

Infection

AtPep1 is an endogenous inducer of innate immune responses. AtPep1 can be isolated from Arabidopsis thaliana leaves. AtPep1 activates the transcription of defensin (PDF1.2), the expression of PROPEP1, the synthesis of hydrogen peroxide (H2O2) near leaf veins, and the alkalization of Arabidopsis suspension cell culture medium. AtPep1 induces the expression of genes encoding defensins and PR-1. AtPep1 is applicable to studies related to Pythium irregulare infection and pathogen infection .
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Cat. No.: HY-N7057S1
CAS No.: 134646-27-8
Synonyms: Pelargonic acid-d3
Nonanoic acid (Pelargonic acid)-d3 is the deuterium labeled Nonanoic acid (HY-N7057). Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2 .
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Cat. No.: HY-N7057S3
CAS No.: 62689-94-5
Synonyms: Pelargonic acid-d2; Pelargonic acid-d2 (n-Nonanoic acid, C9 )
Nonanoic acid (Pelargonic acid)-d2 is the deuterium labeled Nonanoic acid (HY-N7057) . Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2 .
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Cat. No.: HY-P4902
CAS No.: 724760-19-4
Target:  

P-glycoprotein HIV

Research Areas:  

Infection

Retrocyclin-1 is a kind of Theta-defensin. Retrocyclin-1 recognizes and binds to carbohydrate-containing surface molecules, to protect cells from HIV-1 infection. Retrocyclin-1 exhibits high affinity to fetuin, gp120 (Kd=35.4 nM), CD4 (Kd=31 nM), and galactosylceramide (Kd=24.1 nM) .
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Cat. No.: HY-P2313
CAS No.: 372146-20-8
Synonyms: HβD-2
Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus . Human β-defensin-2 can be used for the study of colitis .
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