136661-76-2
Chemical Structure
Defensin HNP-3 human
- CAS No.: 136661-76-2
- Formula:C151H222N44O40S6
- Molecular Weight:3486.04
SMILES: C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@]5(NC(=O)[C@]([C@@H](C)O)(NC(=O)CNC(=O)[C@H](CC6=CC=C(O)C=C6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@@]7(CSSC[C@](NC(=O)[C@H](CC8=CC=CC=C8)NC(=O)[C@H](C)NC3=O)(C(=O)N[C@H](C(O)=O)CSSC[C@H](NC([C@H](CC(O)=O)N)=O)C(=O)N[C@@H](CC9=CC=C(O)C=C9)C(=O)N[C@](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]([C@H](CC)C)(C(=O)N%10[C@](C(=O)N[C@@H](C)C(=O)N7)(CCC%10)[H])[H])(CSSC5)[H])[H])[H])[H])[H])[H])[H]
Biological Activity: Defensin HNP-3 human is an α-defensin stored in the azurophilic granules of human neutrophils. Defensin HNP-3 human exerts broad-spectrum bactericidal, antifungal and antiviral activities mainly by forming bacterial membrane pores, and acts as a chemoattractant for monocytes and T cells. Defensin HNP-3 human maintains epithelial integrity to support periodontal tissue homeostasis, and exerts concentration-dependent effects on epithelial cell proliferation, adhesion and bacterial adhesion. Defensin HNP-3 human targets solid tumors and leukemia by inducing single-strand DNA breaks and membrane permeabilization in tumor cells via electrostatic binding and pore formation. Defensin HNP-3 human is abundant in human tongue squamous cell carcinoma and neutrophils infiltrating oral squamous cell carcinoma. Defensin HNP-3 human can be applied to research related to periodontitis and human tongue squamous cell carcinoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Defensin HNP-3 human | 97.59% | Defensin HNP-3 human is an α-defensin stored in the azurophilic granules of human neutrophils. Defensin HNP-3 human exerts broad-spectrum bactericidal, antifungal and antiviral activities mainly by forming bacterial membrane pores, and acts as a chemoattractant for monocytes and T cells. Defensin HNP-3 human maintains epithelial integrity to support periodontal tissue homeostasis, and exerts concentration-dependent effects on epithelial cell proliferation, adhesion and bacterial adhesion. Defensin HNP-3 human targets solid tumors and leukemia by inducing single-strand DNA breaks and membrane permeabilization in tumor cells via electrostatic binding and pore formation. Defensin HNP-3 human is abundant in human tongue squamous cell carcinoma and neutrophils infiltrating oral squamous cell carcinoma. Defensin HNP-3 human can be applied to research related to periodontitis and human tongue squamous cell carcinoma. | ||||||||||||||||||||
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References
- [1]. Lundy FT, et al. Identification and overexpression of human neutrophil alpha-defensins (human neutrophil peptides 1, 2 and 3) in squamous cell carcinomas of the human tongue. Oral Oncol. 2004;40(2):139-144. [Content Brief]
- [2]. Gursoy U K, et al. Human neutrophil defensins and their effect on epithelial cells[J]. Journal of periodontology, 2013, 84(1): 126-133.
