3-Hydroxyacetophenone (Synonyms: m-Hydroxyacetophenone)

Cat. No.: HY-Y0603 Purity: 99.99%: FAQs
Data Sheet SDS COA Handling Instructions

3-Hydroxyacetophenone (m-Hydroxyacetophenone) is the hydroxy-substituted alkyl phenyl ketone that can be used in synthesis of enantiopure (-)-rivastigmine.

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3-Hydroxyacetophenone Chemical Structure

CAS No. : 121-71-1

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10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
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Description

3-Hydroxyacetophenone (m-Hydroxyacetophenone) is the hydroxy-substituted alkyl phenyl ketone that can be used in synthesis of enantiopure (-)-rivastigmine^[1]^[2].

Molecular Weight

136.15

Appearance

Solid

Formula

C₈H₈O₂

CAS No.

121-71-1

SMILES

CC(C1=CC=CC(O)=C1)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (734.48 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.3448 mL	36.7242 mL	73.4484 mL
5 mM	1.4690 mL	7.3448 mL	14.6897 mL
10 mM	0.7345 mL	3.6724 mL	7.3448 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (18.36 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (18.36 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (18.36 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 99.99%

Select Batch:

Data Sheet (271 KB) SDS (392 KB)

COA (246 KB) HNMR (86 KB) RP-HPLC (177 KB)

Handling Instructions (2659 KB)

References

[1]. Katharine Moore Tibbetts, et al. Controlling dissociation of alkyl phenyl ketone radical cations in the strong-field regime through hydroxyl substitution position. J Phys Chem A. 2014 Sep 18;118(37):8170-6. [Content Brief]

[2]. Kiwon Han, et al. Chemoenzymatic synthesis of rivastigmine via dynamic kinetic resolution as a key step. J Org Chem. 2010 May 7;75(9):3105-8. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

3-Hydroxyacetophenone121-71-1m-HydroxyacetophenoneOthersInhibitorinhibitorinhibit

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