452274-53-2
Chemical Structure
Human β-defensin-1
Synonym(s): HβD-1
- CAS No.: 452274-53-2
- Formula:C167H256N48O50S6
- Molecular Weight:3928.53
SMILES: O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(N)=O)C(N[C@@H](CSSC[C@@H]3NC4=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@H]4CCCCN)=O)=O)=O)=O)=O)=O)NC6=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(O)=O)=O)NC3=O)C(N8[C@@H](CCC8)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(NCC(N[C@H]6[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Biological Activity: Human β-defensin-1 (HβD-1) is an antimicrobial peptide and immunomodulator that induces angiogenin secretion from fibroblasts through EGFR, JNK, NF-κB, Src, and p38 signaling pathways, and binds CCR6 to activate G protein signaling, while also inducing ER stress, apoptosis, cell cycle arrest, and autophagy. Human β-defensin-1 can be used in research on hepatocellular carcinoma, influenza A virus infection, male infertility, colon cancer, and bacterial infections caused by antibiotic-resistant strains[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Human β-defensin-1 | 97.24% | Human β-defensin-1 (HβD-1) is an antimicrobial peptide and immunomodulator that induces angiogenin secretion from fibroblasts through EGFR, JNK, NF-κB, Src, and p38 signaling pathways, and binds CCR6 to activate G protein signaling, while also inducing ER stress, apoptosis, cell cycle arrest, and autophagy. Human β-defensin-1 can be used in research on hepatocellular carcinoma, influenza A virus infection, male infertility, colon cancer, and bacterial infections caused by antibiotic-resistant strains. | ||||||||||||||||||||
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References
- [1]. Umehara Y, et al. The Antimicrobial Peptides Human β-Defensins Induce the Secretion of Angiogenin in Human Dermal Fibroblasts. International journal of molecular sciences. 2022 Aug 08;23(15):8800.
- [2]. Othumpangat S, et al. β-Defensin-1 Regulates Influenza Virus Infection in Human Bronchial Epithelial Cells through the STAT3 Signaling Pathway. Pathogens (Basel, Switzerland). 2023 Jan 11;12(1):123.
- [3]. Khayamabed R, et al. Effect of recombinant β-defensin 1 protein on human sperm motility and viability. Andrologia. 2020 Feb;52(1):e13455.
