1. Membrane Transporter/Ion Channel
  2. Chloride Channel

Chlorotoxin 

Cat. No.: HY-P0173 Purity: 97.35%
Data Sheet SDS Handling Instructions

Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity; inhibits the migration of U251MG cell with an IC50 of 600 nM.

For research use only. We do not sell to patients.
Chlorotoxin Chemical Structure

Chlorotoxin Chemical Structure

CAS No. : 163515-35-3

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10 mM * 1 mL in Water $2373 In-stock
500 ug $150 In-stock
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5 mg $450 In-stock
10 mg $650 In-stock
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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity; inhibits the migration of U251MG cell with an IC50 of 600 nM.

IC50 & Target

IC50: 600 nM (U251MG cell)[1]

In Vitro

Chlorotoxin (CTX) preferentially binds to tumor cells and has been harnessed to develop an imaging agent to help visualize tumors during surgical resection. In addition, chlorotoxin has potential as a vehicle to deliver anti-cancer drugs specifically to cancer cells. Chlorotoxin is shown to bind glioma cells, but is unable to bind normal rat astrocytes and Te671, a human rhabdomyosarcoma cell line. Chlorotoxin inhibits the migration of U251MG (glioma) cells, with an IC50 of 600 nM[1]. Chlorotoxin binds to glioma cells is specific and involves high affinity (Kd=4.2 nM) and low affinity (Kd=660 nM) binding sites[2].Small conductance chloride channels are shown to be potently blocked by CTX. CTX has been used as a general pharmacological tool to investigate the function of chloride channels[3].

In Vivo

Chlorotoxin shows insecticidal activity on insects and other invertebrates. After the administration of I-CTX to tumor-bearing mice, the peptides accumulated within the tumor[1].CTX selectively accumulates in the brain of tumor-bearing mice with calculated brain: muscle ratios of 36.4% of injected dose/g (ID/g), as compared to 12.4%ID/g in control animals[2].

Clinical Trial
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References
Animal Administration
[2]

Mouse: At 24, 48, 72, and 96 h after tumor-bearing and control SCID mice are injected with 125l-labeled CTX, they are anesthetized and imaged. Both 125I- and 131l-labeled CTX-injected animals and their control counterparts are killed at indicated time points for biodistribution studies[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

3995.71

Formula

C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

CAS No.

163515-35-3

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Chlorotoxin
Cat. No.:
HY-P0173
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