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Results for "

gastroprotective agent

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

5

Natural
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2

Isotope-Labeled Compounds

1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0360
    Rebamipide
    5+ Cited Publications

    OPC12759; Proamipide

    		 COX Inflammation/Immunology Cancer
    Rebamipide (OPC12759) is an orally active gastroprotective agent that enhances the production of endogenous PGs (especially intragastric PGE2) by inducing COX-2 expression, thereby protecting the gastric mucosa from injury. Rebamipide exerts anti-proliferative activity against gastric cancer cells. Rebamipide can be used in studies of mucosal protection, gastroduodenal ulcer, gastritis and gastric cancer .
    Rebamipide
  • HY-N0203
    Atractylenolide III
    3 Publications Verification

    ICodonolactone; 8β-Hydroxyasterolide

    		 Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Atractylenolide III (ICodonolactone) is the main component of Atractylodes rhizome and has the activity of inducing apoptosis in lung cancer cells. Atractylenolide III is an orally active gastroprotective agent .
    Atractylenolide III
  • HY-B0968A
    Trimetazidine
    Maximum Cited Publications
    17 Publications Verification

    		 Autophagy Cardiovascular Disease
    Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor .
    Trimetazidine
  • HY-B0968
    Trimetazidine dihydrochloride
    Maximum Cited Publications
    17 Publications Verification

    		 Autophagy Cardiovascular Disease
    Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor .
    Trimetazidine dihydrochloride
  • HY-B0900
    Anethole
    2 Publications Verification

    Anise camphor; p-Propenylanisole; Isoestragole

    		 Environmental Pollutants Apoptosis NF-κB Fungal Bacterial MMP Infection Neurological Disease Inflammation/Immunology Cancer
    Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .
    Anethole
  • HY-108292
    Propacetamol hydrochloride

    		NF-κB Neurological Disease Cancer
    Propacetamol hydrochloride is an orally active prodrug of paracetamol and an inducer of acute liver injury models, with multiple properties including antinociception, antioxidation and gastroprotection. Propacetamol hydrochloride potentiates Tramadol and attenuates Aspirin (HY-14654)-induced gastric mucosal damage and lipid peroxidation. Under specific conditions, Propacetamol hydrochloride also acts as a hepatotoxic inducer, triggering acute liver injury, oxidative stress and apoptosis, with strain differences in toxicity sensitivity. Propacetamol hydrochloride can be used in the research of acute liver injury, drug-induced hepatotoxicity and gastric mucosal damage .
    Propacetamol hydrochloride
  • HY-108278
    Zolimidine

    		Drug Derivative Endocrinology
    Zolimidine, a derivate of imidazopyridine, is an orally active antiulcer agent. Zolimidine stimulates mucus secretion in intestinal mucosal cells and enhacnes intestinal wall more resistant to ulceration. Zolimidine exhibits gastroprotective effect in duodenal ulcer research .
    Zolimidine
  • HY-N12717
    Casuarinin

    		PAK FASTK HSP p38 MAPK NF-κB NO Synthase COX HSV Caspase TNF Receptor Fungal Apoptosis Infection Inflammation/Immunology Cancer
    Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase‑3 and elevation of TNF‑α, inhibits the growth of Candida albicans, and inhibits HSV‑2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections .
    Casuarinin
  • HY-B0968R
    Trimetazidine dihydrochloride (Standard)
    4 Publications Verification

    		 Reference Standards Autophagy Cardiovascular Disease
    Trimetazidine (dihydrochloride) (Standard) is the analytical standard of Trimetazidine (dihydrochloride). This product is intended for research and analytical applications. Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor .
    Trimetazidine dihydrochloride (Standard)
  • HY-N0203R
    Atractylenolide III (Standard)

    ICodonolactone (Standard); 8β-Hydroxyasterolide (Standard)

    		 Reference Standards Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Atractylenolide III (Standard) is the analytical standard of Atractylenolide III. This product is intended for research and analytical applications. Atractylenolide III (ICodonolactone) is the main component of Atractylodes rhizome and has the activity of inducing apoptosis in lung cancer cells. Atractylenolide III is an orally active gastroprotective agent .
    Atractylenolide III (Standard)
  • HY-107320
    Amtolmetin guacil

    		Prostaglandin Receptor COX NO Synthase Inflammation/Immunology
    Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis .
    Amtolmetin guacil
  • HY-135408
    Trimetazidine-N-oxide

    		Drug Metabolite Cardiovascular Disease Inflammation/Immunology
    Trimetazidine-N-oxide is the major active metabolite of Trimetazidine. Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM. Trimetazidine is an effective antianginal agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties.
    Trimetazidine-N-oxide
  • HY-B0968S
    Trimetazidine-d8 dihydrochloride

    		Autophagy Cardiovascular Disease
    Trimetazidine-d8 (dihydrochloride) is the deuterium labeled Trimetazidine dihydrochloride. Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor .
    Trimetazidine-d8 dihydrochloride
  • HY-B0360R
    Rebamipide (Standard)

    		COX Reference Standards Inflammation/Immunology Cancer
    Rebamipide (Standard) is the analytical standard of Rebamipide. This product is intended for research and analytical applications. Rebamipide (OPC12759) is an orally active gastroprotective agent that enhances the production of endogenous PGs (especially intragastric PGE2) by inducing COX-2 expression, thereby protecting the gastric mucosa from injury. Rebamipide exerts anti-proliferative activity against gastric cancer cells. Rebamipide can be used in studies of mucosal protection, gastroduodenal ulcer, gastritis and gastric cancer .
    Rebamipide (Standard)
  • HY-B0900R
    Anethole (Standard)

    Anise camphor (Standard); p-Propenylanisole (Standard); Isoestragole (Standard)

    		 Apoptosis Fungal Bacterial MMP NF-κB Reference Standards Infection Neurological Disease Inflammation/Immunology Cancer
    Anethole (Standard) is the analytical standard of Anethole. This product is intended for research and analytical applications. Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .
    Anethole (Standard)
  • HY-B0968S1
    Trimetazidine-d9 dihydrochloride

    		Isotope-Labeled Compounds Autophagy Cardiovascular Disease
    Trimetazidine-d9 (dihydrochloride) is deuterium labeled Trimetazidine (dihydrochloride). Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor .
    Trimetazidine-d9 dihydrochloride
  • HY-B0968AR
    Trimetazidine (Standard)

    		Reference Standards Autophagy Cardiovascular Disease
    Trimetazidine (Standard) is the analytical standard of Trimetazidine. This product is intended for research and analytical applications. Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor .
    Trimetazidine (Standard)
  • HY-127145
    Parsalmide

    		COX Inflammation/Immunology
    Parsalmide is an orally active non-steroidal anti-inflammatory drug and gastroprotective agent, with an IC50 of 9.92 μM against COX-1 and 155 μM against COX-2. Parsalmide prevents gastric injury and reduces edema. Parsalmide can be used in the research of arthritis .
    Parsalmide
  • HY-108278R
    Zolimidine (Standard)

    		Drug Derivative Reference Standards Endocrinology
    Zolimidine (Standard) is the analytical standard of Zolimidine (HY-108278). This product is intended for research and analytical applications. Zolimidine, a derivate of imidazopyridine, is an orally active antiulcer agent. Zolimidine stimulates mucus secretion in intestinal mucosal cells and enhacnes intestinal wall more resistant to ulceration. Zolimidine exhibits gastroprotective effect in duodenal ulcer research .
    Zolimidine (Standard)

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