2. Disease Areas
  3. Digestive System Disease
  4. Gastric Disease Peptic Ulcer Disease
  5. Gastric Ulcer
  6. SCH 12223 free base

SCH 12223 free base is an orally active gastroprotective agent. SCH 12223 free base exhibits gastrointestinal protective action against various noxious stimuli. SCH 12223 free base can be used for research on gastrointestinal diseases.

For research use only. We do not sell to patients.

SCH 12223 free base

SCH 12223 free base Chemical Structure

CAS No. : 89109-20-6

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Description

SCH 12223 free base is an orally active gastroprotective agent. SCH 12223 free base exhibits gastrointestinal protective action against various noxious stimuli. SCH 12223 free base can be used for research on gastrointestinal diseases[1].

In Vivo

SCH 12223 (0.3-3 mg/kg; p.o. or i.v.) free base inhibits the ethanol-induced rat gastric lesions[1].
SCH 12223 (1-10 mg/kg; p.o.) free base lacks antisecretory activity in the pylorus-ligated rats but increases total gastric mucus[1].
SCH 12223 (10-30 mg/kg; p.o.) free base attenuates rat intestinal lesions provoked by Indomethacin (HY-14397)[1].
SCH 12223 (38 days) free base improves rat survival from Indomethacin lethality[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (ethanol-induced gastric lesions)[1]
Dosage: 0.3 mg/kg; 1 mg/kg; 3 mg/kg
Administration: p.o. or i.v.
Result: Inhibited the ethanol-induced rat gastric lesions.
Animal Model: Rats (pylorus-ligated)[1]
Dosage: 10 mg/kg
Administration: p.o.
Result: Lacked antisecretory activity in the pylorus-ligated rats.
Animal Model: Rats (Indomethacin-induced intestinal lesions)[1]
Dosage: 10 mg/kg; 30 mg/kg
Administration: p.o.
Result: Attenuated rat intestinal lesions.
Molecular Weight

294.35

Formula

C18H18N2O2
CAS No.
SMILES

O=C1N(C2=NC=CC=C2C(O)=C1CCCC)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SCH 12223 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH 1222389109-20-6SCH12223SCH-12223Othersgastroprotective agentnoxious stimuligastrointestinal diseasesprostaglandinInhibitorinhibitorinhibit

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