country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-123388

Copy Link Print Information

SCH 12223 free base

SCH 12223 free base is an orally active gastroprotective agent. SCH 12223 free base exhibits gastrointestinal protective action against various noxious stimuli. SCH 12223 free base can be used for research on gastrointestinal diseases.

For research use only. We do not sell to patients.

CAS No.: 89109-20-6
Formula: C₁₈H₁₈N₂O₂
Molecular Weight:294.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

SCH 12223 free base Chemical Structure

CAS No.: 89109-20-6

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

SCH 12223 (0.3-3 mg/kg; p.o. or i.v.) free base inhibits the ethanol-induced rat gastric lesions^[1].
SCH 12223 (1-10 mg/kg; p.o.) free base lacks antisecretory activity in the pylorus-ligated rats but increases total gastric mucus^[1].
SCH 12223 (10-30 mg/kg; p.o.) free base attenuates rat intestinal lesions provoked by Indomethacin (HY-14397)^[1].
SCH 12223 (38 days) free base improves rat survival from Indomethacin lethality^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rats (ethanol-induced gastric lesions)^[1]
Dosage:

0.3 mg/kg; 1 mg/kg; 3 mg/kg
Administration:

p.o. or i.v.
Result:

Inhibited the ethanol-induced rat gastric lesions.

Animal Model:

Rats (pylorus-ligated)^[1]
Dosage:

10 mg/kg
Administration:

p.o.
Result:

Lacked antisecretory activity in the pylorus-ligated rats.

Animal Model:

Rats (Indomethacin-induced intestinal lesions)^[1]
Dosage:

10 mg/kg; 30 mg/kg
Administration:

p.o.
Result:

Attenuated rat intestinal lesions.

Chemical Information

CAS No. 89109-20-6
Molecular Weight 294.35
Formula C₁₈H₁₈N₂O₂
SMILES

O=C1N(C2=NC=CC=C2C(O)=C1CCCC)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chiu PJ, et al. Protective action of SCH 12223 against experimentally induced gastric and intestinal lesions. J Pharmacol Exp Ther. 1988 Aug;246(2):578-84. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote