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Art. -Nr.: HY-127145

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Parsalmide

Parsalmide is an orally active non-steroidal anti-inflammatory drug and gastroprotective agent, with an IC₅₀ of 9.92 μM against COX-1 and 155 μM against COX-2. Parsalmide prevents gastric injury and reduces edema. Parsalmide can be used in the research of arthritis.

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CAS. Nr.: 30653-83-9
Formel: C₁₄H₁₈N₂O₂
Molecular Weight:246.31

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Parsalmide Chemical Structure

CAS. Nr.: 30653-83-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Ovine COX-1

9.92 μM (IC₅₀)

Ovine COX-2

155 μM (IC₅₀)

Alle COX Isoform-spezifische Produkte anzeigen :

In Vitro

Parsalmide (0.01 nM-0.1 mM; 45 min) potently inhibits purified ovine COX-1 with an IC₅₀ of 9.92 μM, and also inhibits purified ovine COX-2 with an IC₅₀ of 155 μM, showing a 16-fold higher selectivity for COX-1 over COX-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Parsalmide (10-100 mg/kg; p.o.; single administration) exhibits dose-dependent anti-inflammatory activity in carrageenan-induced edema rats^[1].
Parsalmide (100 mg/kg; p.o.; single administration) does not induce acute gastric injury in rats at its effective anti-inflammatory dose of 100 mg/kg^[1].
Parsalmide (100 mg/kg; p.o.; single administration) significantly prevents indomethacin (HY-14397)-induced gastric injury in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats treated Carrageenin (male, 120-140 g)^[1]
Dosage:

10 mg/kg; 100 mg/kg
Administration:

p.o.; single dose
Result:

Inhibited paw edema formation by 9% at 10 mg/kg.
Inhibited paw edema formation by 83% at 100 mg/kg.
Exhibited an ED₅₀ of 82 mg/kg for anti-inflammatory activity.

Animal Model:

Wistar rats treated Indomethacin (male, 120-140 g)^[1]
Dosage:

100 mg/kg
Administration:

p.o.; single dose; administered 1 hour before indomethacin
Result:

Significantly reduced indomethacin-induced gastric damage, with a gastric damage score markedly lower than the vehicle-treated control group.

Chemical Information

CAS. Nr. 30653-83-9
Molecular Weight 246.31
Formel C₁₄H₁₈N₂O₂
SMILES

O=C(NCCCC)C1=CC(N)=CC=C1OCC#C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Caliendo G, et al. Synthesis of substituted benzamides as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 but do not cause gastric damage. Eur J Med Chem. 2001;36(6):517-530. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Parsalmide

Alle COX Isoform-spezifische Produkte anzeigen