2. Immunology/Inflammation
  3. COX
  4. Parsalmide

Parsalmide is an orally active non-steroidal anti-inflammatory drug and gastroprotective agent, with an IC50 of 9.92 μM against COX-1 and 155 μM against COX-2. Parsalmide prevents gastric injury and reduces edema. Parsalmide can be used in the research of arthritis.

For research use only. We do not sell to patients.

Parsalmide

Parsalmide Chemical Structure

CAS No. : 30653-83-9

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Parsalmide Related Antibodies

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Description

Parsalmide is an orally active non-steroidal anti-inflammatory drug and gastroprotective agent, with an IC50 of 9.92 μM against COX-1 and 155 μM against COX-2. Parsalmide prevents gastric injury and reduces edema. Parsalmide can be used in the research of arthritis[1].

IC50 & Target[1]

Ovine COX-1

9.92 μM (IC50)

Ovine COX-2

155 μM (IC50)

In Vitro

Parsalmide (0.01 nM-0.1 mM; 45 min) potently inhibits purified ovine COX-1 with an IC50 of 9.92 μM, and also inhibits purified ovine COX-2 with an IC50 of 155 μM, showing a 16-fold higher selectivity for COX-1 over COX-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parsalmide Related Antibodies
In Vivo

Parsalmide (10-100 mg/kg; p.o.; single administration) exhibits dose-dependent anti-inflammatory activity in carrageenan-induced edema rats[1].
Parsalmide (100 mg/kg; p.o.; single administration) does not induce acute gastric injury in rats at its effective anti-inflammatory dose of 100 mg/kg[1].
Parsalmide (100 mg/kg; p.o.; single administration) significantly prevents indomethacin (HY-14397)-induced gastric injury in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats treated Carrageenin (male, 120-140 g)[1]
Dosage: 10 mg/kg; 100 mg/kg
Administration: p.o.; single dose
Result: Inhibited paw edema formation by 9% at 10 mg/kg.
Inhibited paw edema formation by 83% at 100 mg/kg.
Exhibited an ED50 of 82 mg/kg for anti-inflammatory activity.
Animal Model: Wistar rats treated Indomethacin (male, 120-140 g)[1]
Dosage: 100 mg/kg
Administration: p.o.; single dose; administered 1 hour before indomethacin
Result: Significantly reduced indomethacin-induced gastric damage, with a gastric damage score markedly lower than the vehicle-treated control group.
Molecular Weight

246.31

Formula

C14H18N2O2
CAS No.
SMILES

O=C(NCCCC)C1=CC(N)=CC=C1OCC#C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Parsalmide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Parsalmide30653-83-9COXCyclooxygenasearthritisindomethacingastric damageovine COX-1cyclooxygenase 2ratsovine COX-2COX-1COX-2edemaInhibitorinhibitorinhibit

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