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Results for "

gene transfer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Bacterial (1) Biochemical Assay Reagents (3) DNA/RNA Synthesis (4) Endogenous Metabolite (1) Environmental Pollutants (1) HSV (1) Liposome (3) Mitochondrial Metabolism (1) Nucleoside Antimetabolite/Analog (1) Oxidative Phosphorylation (1) PDGFR (1) Reactive Oxygen Species (ROS) (1) STAT (1) Thrombin (1)
By Research Areas:	Cancer (9) Endocrinology (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	Nucleoside Analogs (1) Uridine (1) Cationic Lipids (3) Polymers (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Oligonucleotides

Targets Recommended: LAG-3 CGRP Receptor MALT1 Dan family RIG-I-like receptor (RLR) NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112735

Hexadimethrine bromide 105+ Cited Publications Polybrene; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide	Biochemical Assay Reagents	Cancer
Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer .

HY-107911

Protamine sulfate 3 Publications Verification	Thrombin	Metabolic Disease
Protamine sulfate, polycationic peptide and a antiheparin agent, could neutralize the anticoagulant action of heparin and enhances lipid-mediated gene transfer .

HY-113355

NADH	Endogenous Metabolite Apoptosis	Neurological Disease Inflammation/Immunology Endocrinology
NADH is an orally active dehydrogenase coenzyme that acts as a crucial electron carrier in cellular respiration and participates in ATP production. NADH promotes metabolism, supports brain function, and counteracts oxidative stress by transferring electrons to the electron transport chain. As a signaling molecule, NADH regulates multiple biological processes, including anti-apoptosis, synaptic plasticity, gene expression, and calcium homeostasis. Redox imbalance of NADH/NAD⁺ is one of the key pathological mechanisms of various diseases, such as diabetic nephropathy, neurodegenerative diseases, and ischemia-reperfusion injury.

HY-P1876B

NLS (PKKKRKV) (hydrochloride) 3 Publications Verification	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) hydrochloride is the hydrochloride form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research .

HY-P1876

NLS (PKKKRKV) 3 Publications Verification	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the SV40 large T antigen, which mediates the binding of karyophilic proteins to importin α. NLS (PKKKRKV) serves as a method to enhance nuclear entry in the field of gene transfer research .

HY-W590549

Dioleyldimethylammonium chloride DODAC	Liposome	Cancer
Dioleyldimethylammonium chloride (DODAC) is a positively charged lipid promoter with membrane-disrupting activity, which is often formulated into cationic liposomes with dioleoylphosphatidylethanolamine. Dioleyldimethylammonium chloride is used in gene transfection research; through electrostatic interactions, it effectively promotes the binding of programmable fusion vesicles to cells and induces membrane disruption. Dioleyldimethylammonium chloride is also applied in studies on L1210 leukemia and LS180 human colon cancer .

HY-W342664

2'-Deoxy-2'-fluoro-5-iodouridine FIRU	Nucleoside Antimetabolite/Analog HSV	Cancer
2'-Deoxy-2'-fluoro-5-iodouridine (FIRU) is a nucleoside analog. When labeled with ¹²³I, 2'-Deoxy-2'-fluoro-5-iodouridine accumulates highly selectively in tumors expressing the HSV1-tk gene. Radiolabeled 2'-Deoxy-2'-fluoro-5-iodouridine enables imaging of adenovirus-mediated HSV1-tk suicide gene transfer .

HY-143210

Transfectam	Liposome	Metabolic Disease
Transfectam is a cationic lipid able to interact with DNA to form complexes that mediate efficient gene transfer into various eukaryotic cells .

HY-159067

DEAE-dextran, MW 500000 hydrochloride DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides); Diethylaminoethyl-dextran, MW 500000 hydrochloride	Biochemical Assay Reagents	Cancer
DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes .

HY-W059747

Chloroxynil	Environmental Pollutants	Others
Chloroxynil is a Vir gene of Agrobacterium tumefaciens activator. Chloroxynil enhances T-DNA transfer efficiency by activating the expression of Agrobacterium Vir genes. Chloroxynil is promising for research of Agrobacterium-mediated transformation efficiency in legumes and rice .

HY-124843

LLL3 1 Publications Verification CLT-005	STAT Apoptosis	Cancer
LLL3 (CLT-005) is a STAT3 inhibitor. LLL3 inhibits dimerization and phosphorylation of STAT3, thereby preventing intraconuclear transfer of STAT3 and inhibits the expression of STAT3 dependent genes, which encode proteins such as Bcl-xL and cyclin D1. In addition, LLL3 can induce cell growth inhibition and apoptosis in human breast cancer and rhabdomyosarcoma cells via the caspase pathway. LLL3 can be used in the study of STAT3 persistent activation types of cancer .

HY-P1876A

NLS (PKKKRKV) TFA	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) TFA is the TFA form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research .

HY-N11882

Plastoquinone PQ-9	Reactive Oxygen Species (ROS)	Others
Plastoquinone (PQ-9) is a photosynthetic electron carrier as well as a redox sensor capable of regulating state transitions and gene expression. Plastoquinone transfers electrons to the cytochrome b₆/f complex via the Q cycle, and participates in the establishment of the thylakoid transmembrane pH gradient. Plastoquinone can react with ROS. Plastoquinone is used in plant photosynthesis research .

HY-158705

SAINT-2	Liposome	Others
SAINT-2 is a cationic lipid with gene transfection activity and is a pyridyl lipid analog. Molecular membranes prepared by SAINT-2 can interact with plasmids to form lipid complexes. After the complex is taken up by cells, the plasmid dissociates from the lipid complex under the action of DOPE and the plasmid translocates across the endosome and/or nuclear membrane. Thus, SAINT-2 effectively transfers small oligonucleotides into cells .

HY-175454

YH-0623	DNA/RNA Synthesis PDGFR Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
YH-0623 is an orally active mitochondrial RNA polymerase (POLRMT) inhibitor (IC₅₀ = 50.48 nM, Nanoluciferase Bioluminescence Resonance Energy Transfer (NanoBRET) assay). YH-0623 exhibits antiproliferative effects on 22Rv1 cells by reducing the expression of mitochondrial-related genes. YH-0623 inhibits 22Rv1 cell growth, colony formation, and the expression of OXPHOS-related proteins. YH-0623 significantly inhibits tumor growth in a prostate cancer xenograft mouse model. YH-0623 is indicated for prostate cancer research .

HY-163327

pFBC	Biochemical Assay Reagents	Neurological Disease
pFBC ([ ¹⁸F]pEBC) is a covalent CLIP-tag radiotracer for detection of viral reporter gene transfer in the murine brain. pFBC can be used in neurobiological research .

HY-168995

BAR-072	Bacterial	Infection
BAR-072 is a small-molecule inhibitor targeting TraE, with a K_D of 2.7 µM. It significantly inhibits the transfer of the antibiotic resistance-associated plasmid pKM101. BAR-072 shows promise as a candidate compound for blocking the spread of bacterial resistance genes and holds potential for research in infectious disease and antimicrobial resistance control .

Cat. No.	Product Name	Type

HY-112735

Hexadimethrine bromide 105+ Cited Publications Polybrene; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide	Biochemical Assay Reagents
Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer .

HY-143210

Transfectam	Biochemical Assay Reagents
Transfectam is a cationic lipid able to interact with DNA to form complexes that mediate efficient gene transfer into various eukaryotic cells .

HY-159067

DEAE-dextran, MW 500000 hydrochloride DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides); Diethylaminoethyl-dextran, MW 500000 hydrochloride	Biochemical Assay Reagents
DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes .

DEAE-dextran, MW 500000 hydrochloride

DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides); Diethylaminoethyl-dextran, MW 500000 hydrochloride

Biochemical Assay Reagents

DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes .

Cat. No.	Product Name	Target	Research Area

HY-P1876B

NLS (PKKKRKV) (hydrochloride) 3 Publications Verification	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) hydrochloride is the hydrochloride form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research .

HY-P1876

NLS (PKKKRKV) 3 Publications Verification	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the SV40 large T antigen, which mediates the binding of karyophilic proteins to importin α. NLS (PKKKRKV) serves as a method to enhance nuclear entry in the field of gene transfer research .

HY-P1876A

NLS (PKKKRKV) TFA	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) TFA is the TFA form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research .

HY-P10535

AAV-8 NSL epitope	Peptides	Others
The AAV-8 NSL epitope is a specific CD8+ T cell epitope identified from the capsid of an adeno-associated virus (AAV) serotype 8. The AAV-8 NSL epitope has a high affinity for MHC I molecules and is able to bind to MHC I molecules, thereby activating CD8+ T cells. The AAV-8 NSL epitope can be used to study the impact of T cell-mediated immune responses on AAV-mediated gene transfer .

HY-P5508

MUC5AC-13	Peptides	Others
MUC5AC-13 is a biological active peptide. (This glycopeptide is an N-acetyl galactosamine (GalNAc)-modified MUC5AC mucin peptide containing the single site of threonine 13 labeled with GalNAc (T). Polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) catalyzes the transfer* of GalNAc from the nucleotide sugar UDP-GalNAc to threonine. The MUC5AC gene is mainly expressed in gastric and tracheo-bronchial mucosae, and some tumors.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113355

NADH	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite Apoptosis
NADH is an orally active dehydrogenase coenzyme that acts as a crucial electron carrier in cellular respiration and participates in ATP production. NADH promotes metabolism, supports brain function, and counteracts oxidative stress by transferring electrons to the electron transport chain. As a signaling molecule, NADH regulates multiple biological processes, including anti-apoptosis, synaptic plasticity, gene expression, and calcium homeostasis. Redox imbalance of NADH/NAD⁺ is one of the key pathological mechanisms of various diseases, such as diabetic nephropathy, neurodegenerative diseases, and ischemia-reperfusion injury.

HY-N11882

Plastoquinone PQ-9	Structural Classification Natural Products Beta vulgaris Linn. Plants Chenopodiaceae Source Classification	Reactive Oxygen Species (ROS)
Plastoquinone (PQ-9) is a photosynthetic electron carrier as well as a redox sensor capable of regulating state transitions and gene expression. Plastoquinone transfers electrons to the cytochrome b₆/f complex via the Q cycle, and participates in the establishment of the thylakoid transmembrane pH gradient. Plastoquinone can react with ROS. Plastoquinone is used in plant photosynthesis research .

Cat. No.	Product Name		Classification

HY-112735

Hexadimethrine bromide 105+ Cited Publications Polybrene; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide		Polymers
Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer .

HY-W590549

Dioleyldimethylammonium chloride DODAC		Cationic Lipids
Dioleyldimethylammonium chloride (DODAC) is a positively charged lipid promoter with membrane-disrupting activity, which is often formulated into cationic liposomes with dioleoylphosphatidylethanolamine. Dioleyldimethylammonium chloride is used in gene transfection research; through electrostatic interactions, it effectively promotes the binding of programmable fusion vesicles to cells and induces membrane disruption. Dioleyldimethylammonium chloride is also applied in studies on L1210 leukemia and LS180 human colon cancer .

HY-W342664

2'-Deoxy-2'-fluoro-5-iodouridine FIRU		Nucleoside Analogs Uridine
2'-Deoxy-2'-fluoro-5-iodouridine (FIRU) is a nucleoside analog. When labeled with ¹²³I, 2'-Deoxy-2'-fluoro-5-iodouridine accumulates highly selectively in tumors expressing the HSV1-tk gene. Radiolabeled 2'-Deoxy-2'-fluoro-5-iodouridine enables imaging of adenovirus-mediated HSV1-tk suicide gene transfer .

HY-143210

Transfectam		Cationic Lipids
Transfectam is a cationic lipid able to interact with DNA to form complexes that mediate efficient gene transfer into various eukaryotic cells .

HY-158705

SAINT-2		Cationic Lipids
SAINT-2 is a cationic lipid with gene transfection activity and is a pyridyl lipid analog. Molecular membranes prepared by SAINT-2 can interact with plasmids to form lipid complexes. After the complex is taken up by cells, the plasmid dissociates from the lipid complex under the action of DOPE and the plasmid translocates across the endosome and/or nuclear membrane. Thus, SAINT-2 effectively transfers small oligonucleotides into cells .

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gene transfer

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Oligonucleotides

Natural
Products