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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
halo
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "halo" in MCE Product Catalog:
5
5 Cited Publications
Cat. No.: HY-D2270
CAS No.: 2764890-88-0
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1 Cited Publications
HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two Halo-tagged endoplasmic reticulum-localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM. HaloPROTAC-E significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy.
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1 Cited Publications
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HaXS8 is a dimerizer that can promote a covalent and irreversible intracellular dimerization of HaloTag and SNAP-tagged proteins of interest. HaXS8 does not interfere with PI3K/mTOR signaling .
Cat. No.: HY-151716
CAS No.: 1808119-16-5
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Halo-DBCO is a click chemistry reagent containing dibenzocyclooctyne (DBCO). Halo-DBCO can be used as a ligand to react with HaloTag to form covalent HaloTag ligand couples .
HaloAUTAC tt15 is an autophagy-targeting chimera (AUTAC), that targets the Halo Tag carrying proteins, and degrades via the autophagy mechanism .
Cat. No.: HY-159493
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BI2536-PEG2-Halo is a bifunctional molecule containing a ligand for Halo tag and a Polo-like kinase 1 (PLK1) inhibitor BI-2536 (HY-50698). BI2536-PEG2-Halo inhibits the proliferation of 293T cells with Halo-p53R273H(FL)-mCherry tag (IC50=23 nM), exhibits selective toxicity against p53 mutant cancer cells .
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NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research .
Cat. No.: HY-148170
CAS No.: 207920-87-4
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L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis .
Cat. No.: HY-D2923
CAS No.: 1811539-43-1
Cat. No.: HY-150265
CAS No.: 2137895-00-0
Synonyms: TMP-NVOC linker-halo
TNH (TMP-NVOC linker-Halo) is a dimeric protein chemical inducer that can enter living cells and recruit proteins to cellular structures. TNH senses light signals and acts by recruiting proteins to kinetochores and releasing them from kinetochores (depending on CENP-E (kinesin-7)) .
Cat. No.: HY-N16036
CAS No.: 2342575-90-8
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Cat. No.: HY-DY1107
CAS No.: 2764890-88-0
Solvent and concentration: DMSO: 5 mM
Cat. No.: HY-148957
CAS No.: 55612-18-5
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5-Bromo-2′-deoxy-2′-fluorouridine (Example 1), a 5-halo analog, is potential as an antiviral agent .
Cat. No.: HY-D3366
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Th-TMR-S-Halo is a fluorescent probe for HaloTag labeling and live-cell imaging, including super-resolution imaging and real-time visualization of endoplasmic reticulum (ER) vortex formation under ER stress conditions. Th-TMR-S-Halo shows weak fluorescence in the free state, and upon covalent binding to HaloTag, fluorescence activation is achieved by restricting the rotation of the thiophene ring. Th-TMR-S-Halo can be used in studies related to intracellular protein localization, cytoskeleton structure, and ER vortex formation. Live-cell NSPARC super-resolution detection is performed using Ex/Em = 561/570-616 nm .
Cat. No.: HY-D3446
CAS No.: 2358677-26-4
Cat. No.: HY-P706145
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
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Cat. No.: HY-180547
CAS No.: 3070832-68-4
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MRC71 is a TRIMTAC degrader that recruits endogenous TRIM21 E3 ligase at one end and covalently binds to HaloTag-fusion target proteins at the other end. MRC71 selectively degrades oligomeric CAV1- and Cavin1-mEGFP-Halo, but not monomeric mEGFP-Halo, and exhibits a typical concentration-dependent degradation profile with a hook effect. MRC71 can be used to verify TRIMTAC ternary complex formation and state-selective degradation in cells .
Cat. No.: HY-129621
CAS No.: 1261238-21-4
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N3-PEG5-C6-Cl is a PEG PROTAC linker, can be used for synthesis of HALo PROTAC .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
