207920-87-4
207920-87-4
Chemical Structure
L-I-OddU
- CAS No.: 207920-87-4
- Formula:C8H9IN2O5
- Molecular Weight:340.07
IUPAC Name: 1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)-5-iodopyrimidine-2,4(1H,3H)-dione
InChIKey: GFRQBEMRUYIKAQ-WDSKDSINSA-N
SMILES: OC[C@@H]1O[C@H](N(C=C(C(N2)=O)I)C2=O)CO1
Biological Activity: L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis[1][2].
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L-I-OddU | L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis. | |||||||||||||||||||||
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References
- [1]. Kira T, et, al. Anti-Epstein-Barr virus (EBV) activity of beta-L-5-iododioxolane uracil is dependent on EBV thymidine kinase. Antimicrob Agents Chemother. 2000 Dec;44(12):3278-84. [Content Brief]
- [2]. Focher F, et, al. Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development. Curr Drug Targets Infect Disord. 2003 Mar;3(1):41-53. [Content Brief]
