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HaXS8 

Cat. No.: HY-131015
Handling Instructions

HaXS8 is a dimerizer that can promote a covalent and irreversible intracellular dimerization of HaloTag and SNAP-tagged proteins of interest. HaXS8 does not interfere with PI3K/mTOR signaling.

For research use only. We do not sell to patients.

HaXS8 Chemical Structure

HaXS8 Chemical Structure

CAS No. : 2080306-25-6

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Description

HaXS8 is a dimerizer that can promote a covalent and irreversible intracellular dimerization of HaloTag and SNAP-tagged proteins of interest. HaXS8 does not interfere with PI3K/mTOR signaling[1][2].

In Vitro

HaXS8 promotes intracellular dimerization of Halo-GFP and SNAP-GFP fusion proteins reached >65%, and displays significant intracellular dimerization as low as 50 nM in HeLa cells[1].
HaXS8 (0.5 μM; 40 min) induces a rapid and efficient cross-linking of the membrane anchor and the iSH2 construct, and triggers the activation of the downstream targets PKB/Akt and mTOR in HEK293 cells[1].
HaXS8 (0.5 μM; 40 min) does not upregulate MAPK phosphorylation in HEK293 cells[1].
HaXS8 (0.5 μM; 1 h) does not interfere with PI3K/mTOR signaling in HEK293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

787.20

Formula

C₃₅H₄₃ClF₄N₆O₈

CAS No.

2080306-25-6

SMILES

NC1=NC2=C(C(OCC3=CC=C(C=C3)CNC(COC4=C(C(F)=C(C(F)=C4F)OCCOCCOCCOCCOCCCCCCCl)F)=O)=N1)N=CN2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

HaXS8HaXS 8HaXS-8OthersdimerizerdimerizationHalo,TagSNAP-taggedInhibitorinhibitorinhibit

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