2365478-58-4
Chemical Structure
HaloPROTAC-E
- CAS No.: 2365478-58-4
- Formula:C39H56ClN5O8S
- Molecular Weight:790.41
IUPAC Name: 2-methyl-1,2,3,4,10,14b-hexahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepine-3,3,4,4-d4 hydrochloride
InChIKey: NJCGXLMTZGCSRS-JSWXEYCZSA-N
SMILES: O=C(C1(CC1)C#N)N[C@@H](C(C)(C)C)C(N(C[C@@H]2O)[C@@H](C2)C(NCC(C=CC(C(SC=N3)=C3C)=C4)=C4OCCOCCOCCOCCCCCCCl)=O)=O
Biological Activity: HaloPROTAC-E is a SGK3/VPS34 HaloPROTAC degrader that degrades Halo-tagged SGK3 and VPS34, with a DC50 of 3-10 nM in HEK293 cells. HaloPROTAC-E induces ubiquitination and proteasomal degradation of target proteins. HaloPROTAC-E blocks downstream phosphorylation of SGK3 substrate NDRG1. HaloPROTAC-E is applicable for cancer research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HaloPROTAC-E | 98.76% | HaloPROTAC-E is a SGK3/VPS34 HaloPROTAC degrader that degrades Halo-tagged SGK3 and VPS34, with a DC50 of 3-10 nM in HEK293 cells. HaloPROTAC-E induces ubiquitination and proteasomal degradation of target proteins. HaloPROTAC-E blocks downstream phosphorylation of SGK3 substrate NDRG1. HaloPROTAC-E is applicable for cancer research. | ||||||||||||||||||||
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Similarity Score 0.75
HY-139334VH 101 phenol-alkylC6-amine dihydrochloride -
Similarity Score 0.74
HY-173253E3 Ligase Ligand-linker Conjugate 173 -
Similarity Score 0.74
HY-111997VH285-PEG4-C4-Cl -
Similarity Score 0.73
HY-139335VH 101 phenol-alkylC4-amine dihydrochloride -
Similarity Score 0.73
HY-136183(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride -
Similarity Score 0.73
HY-176338(S,S,S)-VH032-cyclopropane-F-C4-aldehyde -
Similarity Score 0.72
HY-112495VH032-PEG5-C6-Cl -
Similarity Score 0.72
HY-103605R(S,R,S)-AHPC-C6-PEG3-C4-Cl (Standard) -
Similarity Score 0.71
HY-181791VHL Ligand 39 -
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