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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
hexokinase 2
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "hexokinase 2" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: BNBZ; hexokinase 2 inhibitor 1
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Benitrobenrazide (BNBZ) is the orally active inhibitor for hexokinase 2 with an IC50 of 0.53 µM. Benitrobenrazide causes DNA damage, and exhibits antitumor effect .
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2 Cited Publications
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PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research .
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2 Cited Publications
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2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a Ki value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research .
Cat. No.: HY-175035
CAS No.: 3114833-48-3
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HK-2-IN-1 is a Hexokinase 2 (HK-2) inhibitor. HK-2-IN-1 exhibits a non-activating effect on human recombinant HK-2 enzyme. HK-2-IN-1 has anti-tumor activity, affecting immune cells in the tumor microenvironment. HK-2-IN-1 has immunomodulatory effects and is potentially useful in the study of cancers such as colon cancer, liver cancer, and breast cancer .
Cat. No.: HY-N2126
CAS No.: 952068-57-4
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Cat. No.: HY-P10108
Synonyms: Hxk2VBD peptide, cell-permeable
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Cat. No.: HY-W000133
CAS No.: 31112-62-6
Synonyms: Amipaque
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Metrizamide (Amipaque) is used as the contrast medium for angiography in neuroradiological investigations . Metrizamide inhibits human brain hexokinase .
Cat. No.: HY-168717
CAS No.: 3056278-80-6
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HK2-IN-2 (Compound 26) is a Hexokinase 2 inhibitor that demonstrates significant anti-tumor activity by targeting microtubules and Hexokinase 2, with an IC50 value of 0.764 μM against MD-MBA-231 cells. HK2-IN-2 effectively inhibits the activity of Hexokinase 2, leading to the accumulation of Reactive Oxygen Species and dysfunction of the mitochondrial membrane potential (MMP), thereby promoting apoptosis and blocking the cell cycle .
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2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive and 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a Ki value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the generation and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research .
Cat. No.: HY-P703943
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HK2; HKII; hexokinase 2; hexokinase-2, Muscle; hexokinase Type II; Phosphotransferase; hexokinase-2; HK II; Muscle Form hexokinase; HXK2; hexokinase-B
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Cat. No.: HY-P704013
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: HK2; HKII; hexokinase 2; hexokinase-2, Muscle; hexokinase Type II; Phosphotransferase; hexokinase-2; HK II; Muscle Form hexokinase; HXK2; hexokinase-B
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Cat. No.: HY-P703943Y
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HK2; HKII; hexokinase 2; hexokinase-2, Muscle; hexokinase Type II; Phosphotransferase; hexokinase-2; HK II; Muscle Form hexokinase; HXK2; hexokinase-B
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Cat. No.: HY-P700580
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HK1; Glycolytic Enzyme; hexokinase 1; hexokinase IR; Brain Form hexokinase; hexokinase-2; hexokinase Type I; NEDVIBA; hexokinase-A; HK1-Tc; hexokinase-1; CNSHA5; hexokinase; HMSNR; HK1-Tb; RP79; HK1-Ta; NMSR; HKI; HXK1; Neuropathy, Hereditary Motor And Se
Cat. No.: HY-P700581
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HK1; Glycolytic Enzyme; hexokinase 1; hexokinase IR; Brain Form hexokinase; hexokinase-2; hexokinase Type I; NEDVIBA; hexokinase-A; HK1-Tc; hexokinase-1; CNSHA5; hexokinase; HMSNR; HK1-Tb; RP79; HK1-Ta; NMSR; HKI; HXK1; Neuropathy, Hereditary Motor And Se
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Cat. No.: HY-139409B
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2-Deoxy-D-glucose 6-phosphate sodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a Ki value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate sodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate sodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate sodium can be used in cancer-related research .
Cat. No.: HY-183809
CAS No.: 3124329-46-7
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ZSW is a hexokinase 2 (HK2) inhibitor with human HK2 IC50 of 0.48 μM, human HK2 Ka of 252.00 μM, and selectivity over HK3 and GCK. ZSW binds directly to HK2, inhibits its enzymatic activity, modulates macrophage phenotypes through glycolysis inhibition, and inhibits NF-κB nuclear translocation by preventing IκBα phosphorylation and degradation. ZSW alleviates inflammatory bowel disease (IBD) and improves the intestinal inflammatory state of IBD mice. ZSW can be used for the research of inflammatory bowel disease .
Cat. No.: HY-182243
CAS No.: 2748366-80-3
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HK2-IN-4 is a selective hexokinase 2 (HK2) inhibitor with an IC50 value of 0.79 μM and a Kd value of 0.41 μM. HK2-IN-4 blocks the interaction between HK2 and voltage-dependent anion channel 1 (VDAC1). HK2-IN-4 reduces lactate and ATP levels in cancer cells. HK2-IN-4 induces the production of apoptosis (apoptosis) markers in cancer cells, including increased p-AMPK/AMPK ratio and Bax levels, as well as decreased Bcl2 levels. HK2-IN-4 inhibits the proliferation of cancer cells with high HK2 expression. HK2-IN-4 can be used in research related to colorectal cancer and non-small cell lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
