390 Results for "

hosts

" in MedChemExpress (MCE) Product Catalog:
Products (390)

390 Results for "hosts" in MCE Product Catalog:

45
Simeprevir
Simeprevir
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45 Publications Verification
Art. -Nr.: HY-10241
CAS. Nr.: 923604-59-5
Reinheit:  98.79%
Synonyms: TMC435; TMC435350
Target:  

HCV HCV Protease SARS-CoV DNA/RNA Synthesis

Forschungsgebiete:  

Infection

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .
24
Calcium disodium edetate hydrate
Calcium disodium edetate hydrate
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24 Cited Publications
Art. -Nr.: HY-W250119
CAS. Nr.: 23411-34-9
Synonyms: EDTA disodium calcium salt hydrate; Ethylenediaminetetraacetic acid disodium calcium salt hydrate
Calcium disodium edetate hydrate (EDTA disodium calcium salt hydrate) is a metal chelator and antifungal agent. Calcium disodium edetate hydrate chelates Mn 2+, damages mitochondria, and interferes with carbohydrate metabolic pathways, particularly the synthesis of pyruvate in glycolysis. Calcium disodium edetate hydrate inhibits Penicillium digitatum and delays conidial germination. Calcium disodium edetate (hydrate) enhances the host defense system of citrus fruits. Calcium disodium edetate hydrate is applicable to research related to citrus green mold .
21
3BDO
3BDO
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21 Cited Publications
Art. -Nr.: HY-U00434
CAS. Nr.: 890405-51-3
Target:  

mTOR Autophagy Apoptosis

Forschungsgebiete:  

Infection Inflammation/Immunology

3BDO is a IFITM3 modulator and mTOR activator with antiviral and autophagy-inhibiting effects. 3BDO exhibits inhibitory activity against porcine coronaviruses. 3BDO increases the protein abundance of IFITM3, inhibits virus-cell membrane fusion, and blocks viral entry. 3BDO inhibits the entry of transmissible gastroenteritis virus, porcine epidemic diarrhea virus, and porcine respiratory coronavirus into host cells. 3BDO can be used for research on porcine coronavirus infection .
17
c-di-AMP disodium
c-di-AMP disodium
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17 Cited Publications
Art. -Nr.: HY-12326A
CAS. Nr.: 2734909-87-4
Synonyms: Cyclic diadenylate disodium; Cyclic-di-AMP disodium
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

STING Bacterial Endogenous Metabolite

c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
17
c-di-AMP diammonium
c-di-AMP diammonium
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17 Cited Publications
Art. -Nr.: HY-12326B
Reinheit:  99.36%
Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

STING Bacterial Endogenous Metabolite

c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
15
Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2)
Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2)
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15 Cited Publications
Art. -Nr.: HY-P99145

Target:  

PD-1/PD-L1

Forschungsgebiete:  

Cancer

Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) is an anti-mouse PD-L1/B7-H1 IgG2b antibody inhibitor derived from host rat. Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) blocks PD-1 signaling. Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) can be used for the research of cancer, such as colon cancer .
11
Umifenovir hydrochloride
Umifenovir hydrochloride
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11 Cited Publications
Art. -Nr.: HY-14904A
CAS. Nr.: 131707-23-8
Reinheit:  99.86%
Target:  

Influenza Virus SARS-CoV CHIKV

Forschungsgebiete:  

Infection

Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells . Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity .
11
Umifenovir
Umifenovir
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11 Cited Publications
Art. -Nr.: HY-14904
CAS. Nr.: 131707-25-0
Reinheit:  98.00%
Target:  

SARS-CoV Influenza Virus CHIKV

Forschungsgebiete:  

Infection

Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells . Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro . Umifenovir shows anti-inflammatory activity .
10
Z-FA-FMK
Z-FA-FMK
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10 Cited Publications
Art. -Nr.: HY-P0109A
CAS. Nr.: 197855-65-5
Synonyms: (1S)-Z-FA-FMK
Target:  

SARS-CoV Cathepsin Apoptosis Caspase

Forschungsgebiete:  

Infection Cancer

Z-FA-FMK ((1S)-Z-FA-FMK) is a potent Cathepsin B and L inhibitor. Z-FA-FMK blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective synthetic retinoid-related molecules (RRMs). Z-FA-FMK inhibits apoptosis. Z-FA-FMK inhibits caspase activity and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Z-FA-FMK is a viral inhibitor. Z-FA-FMK inhibits reovirus replication in a susceptible host .
9
IMP-1088
IMP-1088
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9 Cited Publications
Art. -Nr.: HY-112258
CAS. Nr.: 2059148-82-0
Reinheit:  99.16%
Target:  

DNA/RNA Synthesis

Forschungsgebiete:  

Infection

IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection .
8
Albendazole
Albendazole
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8 Cited Publications
Art. -Nr.: HY-B0223
CAS. Nr.: 54965-21-8
Synonyms: SKF-62979
Target:  

Parasite Microtubule/Tubulin Autophagy Apoptosis Reactive Oxygen Species (ROS) VEGFR HIF/HIF Prolyl-Hydroxylase Antibiotic Bacterial

Forschungsgebiete:  

Infection Cancer

Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells .
7
Cyclo(Phe-Pro)
Cyclo(Phe-Pro)
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7 Cited Publications
Art. -Nr.: HY-P1934
CAS. Nr.: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Target:  

HCV Bacterial Antibiotic Reactive Oxygen Species (ROS)

Forschungsgebiete:  

Infection

Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance .
5
PF-3450074
PF-3450074
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5 Cited Publications
Art. -Nr.: HY-120072
CAS. Nr.: 1352879-65-2
Reinheit:  98.89%
Synonyms: PF-74
Target:  

HIV

Forschungsgebiete:  

Infection

PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle . CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.
5
Dextran sulfate sodium salt (MW 5000)
Dextran sulfate sodium salt (MW 5000)
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5 Cited Publications
Art. -Nr.: HY-116282
CAS. Nr.: 9011-18-1
Reinheit:  99.20%
Synonyms: DSS (MW 5000); DXS (MW 5000)
Dextran sulfate sodium salt (DSS) (MW 5000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt (DSS) with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 5000) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 5000) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (DSS) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 5000) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 5000) inhibits instant blood-mediated inflammatory reaction (IBMIR) .
3
Lactose
Lactose
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3 Cited Publications
Art. -Nr.: HY-B2123
CAS. Nr.: 63-42-3
Category:  

Human Gut Microbiota Metabolites Polysaccharides Microorganisms Other Diseases Endogenous metabolite Disease Research Fields Saccharides

Target:  

Environmental Pollutants Endogenous Metabolite Interleukin Related ERK NF-κB

Lactose is a β-galactoside consisting of galactose and glucose residues, the main carbohydrate in mammalian breast milk. Lactose, a macronutrient and an inducer of host innate immune responses, possesses immune modulatory functions .
3
SP187
SP187
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3 Cited Publications
Art. -Nr.: HY-U00160
CAS. Nr.: 615253-61-7
Synonyms: MON-​DNJ; UV4
Target:  

Flavivirus Dengue Virus

Forschungsgebiete:  

Infection

SP187 is a host-targeted iminosugar with activity against filovirus infections in vitro and in vivo. SP187 is active against influenza and dengue in vivo.
3
Soquelitinib
Soquelitinib
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3 Cited Publications
Art. -Nr.: HY-150298
CAS. Nr.: 2226636-04-8
Reinheit:  99.71%
Synonyms: CPI-818
Target:  

Itk

Forschungsgebiete:  

Inflammation/Immunology Cancer

Soquelitinib (CPI-818) is an orally active and highly selective covalent interleukin-2-inducible kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease, including acute and chronic asthma, pulmonary fibrosis, systemic sclerosis (scleroderma), psoriasis, and acute graft versus host disease with Th2 cytokine product inhibition. Soquelitinib increases tumor infiltration of normal CD8 + cells that possess enhanced T effector function .
3
Anti-Mouse CD8a Antibody (53-6.7)
Anti-Mouse CD8a Antibody (53-6.7)
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3 Cited Publications
Art. -Nr.: HY-P99129

Target:  

Transmembrane Glycoprotein

Forschungsgebiete:  

Inflammation/Immunology

Anti-Mouse CD8a Antibody (53-6.7) is an anti-mouse CD8a IgG2a antibody inhibitor derived from host Rat. Anti-Mouse CD8a Antibody (53-6.7) binds to CD8αβ stabilizes a conformation with a higher affinity for interaction with MHC class I. Anti-Mouse CD8a Antibody (53-6.7) induces the phosphorylation and activation of TCR proximal signaling pathway components Lck and ZAP70 in polyclonal memory T cells. Anti-Mouse CD8a Antibody (53-6.7) depletes CD8+ T cells and neutralizes cytokine in mice .
3
Clesrovimab
Clesrovimab
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3 Cited Publications
Art. -Nr.: HY-P99804
CAS. Nr.: 2429913-18-6
Synonyms: MK1654

Target:  

RSV

Forschungsgebiete:  

Infection

Clesrovimab (MK1654) is a humanized IgG1 monoclonal antibody targeting the respiratory syncytial virus (RSV) protein F. Clesrovimab binds to pre-fusion and post-fusion forms of RSV-A fusion protein with high affinity, with corresponding KD values of 71 pM and 480 pM, respectively. Clesrovimab is applicable for the research of RSV infection .
2
Fosifloxuridine nafalbenamide
Fosifloxuridine nafalbenamide
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2 Cited Publications
Art. -Nr.: HY-109115
CAS. Nr.: 1332837-31-6
Reinheit:  96.31%
Synonyms: NUC-3373
Target:  

Thymidylate Synthase

Forschungsgebiete:  

Cancer

Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunoresearch .
Assay Types