1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. IMP-1088

IMP-1088 

Cat. No.: HY-112258
Handling Instructions

IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection.

For research use only. We do not sell to patients.

IMP-1088 Chemical Structure

IMP-1088 Chemical Structure

CAS No. : 2059148-82-0

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Description

IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection[1].

IC50 & Target

IC50: <1 nM (HsNMT1) and <1 nM (HsNMT2)[1]
Kd: <210 pM (HsNMT1)[1]

In Vitro

IMP-1088 (1-1000 nM) prevents virus-induced cytopathic effect (CPE) in a dose-dependent manner with an IC50 of 17 nM. IMP-1088 (125 nM) complete suppresses of new infectious virus with an IC50 of 5.8 nM. IMP-1088 (1-1000 nM) blocks production of infectious virus and inhibits single cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 h. IMP-1088 significantly inhibits production of infectious virus even when added up to 3 hours post-infection[1].
IMP-1088 (50 nM) significantly less enriches multiple N-myristoylated proteins in enriched samples[1].
IMP-1088 (500 nM) inhibits production of infectious rhinovirus particles by blocking virus assembly in HeLa cells infected with rhinovirus RV-A16 (MOI 20) for 6 h[1].
IMP-1088 (0.24 nM-1 µM; for 24 hours +24 hours washout) has no long-term effect on cell viability and NMT activity fully recovers by 24 h[1].
IMP-1088 potently blocks a key step in viral capsid assembly by inhibition of co-translational myristoylation of a specific virus-encoded protein (VP0). IMP-1088 blocks neither production of viral RNA, nor translation of rhinovirus polyprotein[1].

Molecular Weight

453.53

Formula

C₂₅H₂₉F₂N₅O

CAS No.

2059148-82-0

SMILES

CN1N=C(CN(C)C)C2=C1C=CC(C3=CC=C(F)C(F)=C3OCCC4=C(C)N(C)N=C4C)=C2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

IMP-1088IMP1088IMP 1088DNA/RNA SynthesishumanN-myristoyltransferasesNMT1NMT2HsNMT1HsNMT2rhinovirusreplicationvirus-encodedproteinVP0hBECRV-A16HeLabronchialepithelialInhibitorinhibitorinhibit

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IMP-1088
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HY-112258
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