5 Results for "

human adipose-derived stem cells

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "human adipose-derived stem cells" in MCE Product Catalog:

Vitexin-4''-O-glucoside
Vitexin-4''-O-glucoside
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Cat. No.: HY-N5073
CAS No.: 178468-00-3
Synonyms: 4''-O-Glucosylvitexin
Category:  

Cardiovascular Disease Flavonoids Flavones Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Disease Research Fields

Target:  

JNK p38 MAPK Interleukin Related TNF Receptor Caspase Lactate Dehydrogenase Apoptosis

Vitexin-4''-O-glucoside (4''-O-Glucosylvitexin) is an orally active natural flavonoid component with multiple pharmacological effects including antioxidation, anti-inflammation, cytoprotection and anti-apoptosis. Vitexin-4''-O-glucoside regulates the MAPK signaling pathway by downregulating the phosphorylation levels of JNK and p38, thereby blocking endoplasmic reticulum stress responses. Vitexin-4''-O-glucoside alleviates oxidative stress by reducing MDA content and upregulating the activities of SOD and CAT, attenuates inflammation by downregulating the expressions of inflammatory factors TNF-α, IL-1β and IL-6, and also reduces LDH release and inhibits caspase-3 activation. Vitexin-4''-O-glucoside effectively improves drug-induced acute liver injury and exerts significant protective effects against myocardial hypoxia/reoxygenation injury. Vitexin-4''-O-glucoside can be used in studies on acute liver injury, cardiovascular diseases and myocardial hypoxia-reoxygenation injury .
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Sphingosylphosphorylcholine
Sphingosylphosphorylcholine
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Cat. No.: HY-132187
CAS No.: 1670-26-4
Purity:  99.50%
Category:  

Natural Products Endogenous metabolite

Target:  

TGF-beta/Smad TRP Channel Apoptosis PAI-1

Sphingosylphosphorylcholine is a bioactive lipid and a major component of plasma high-density lipoprotein that binds to OGR1 with a Kd of 33.3 nM. Sphingosylphosphorylcholine triggers delayed phosphorylation of Smad2, upregulates α-SMA expression, and activates TRPM3. Sphingosylphosphorylcholine reduces Apoptosis and upregulates the expression of uPA and its receptor uPA-R. Sphingosylphosphorylcholine exerts anti-apoptotic, anti-cardiac hypertrophy and pro-wound healing effects. Sphingosylphosphorylcholine induces scratching behavior in mice. Sphingosylphosphorylcholine is used in studies related to atopic dermatitis, promyelocytic leukemia, heart failure, myocardial ischemia/reperfusion injury, ovarian cancer, breast cancer, pancreatic cancer, and skin wound healing disorders in genetically impaired healing diabetes .
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Maxadilan
Maxadilan
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Cat. No.: HY-P3483
CAS No.: 135374-80-0
Target:  

PACAP Receptor Caspase Apoptosis PKA Interleukin Related TNF Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease

Maxadilan is a specific irreversible PAC1 receptor agonist and a potent vasodilator peptide present in the salivary glands of sand flies. Maxadilan exhibits anti-apoptotic activity in hADSCs. Maxadilan inhibits pro-inflammatory cytokines (TNF-α) and enhances anti-inflammatory mediators (IL-10). Maxadilan can activate leukocytes and inhibit vascular permeability through PAC1 receptors. Maxadilan promotes neural differentiation of human adipose-derived stem cells. Maxadilan can be used to study endotoxin shock, atherosclerosis, and neurodegenerative diseases [1] [2] [3] [4] [5].
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Maxadilan TFA
Maxadilan TFA
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Cat. No.: HY-P3483A
Target:  

PACAP Receptor Caspase Apoptosis PKA Interleukin Related TNF Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease

Maxadilan TFA is a specific irreversible PAC1 receptor agonist and a potent vasodilator peptide present in the salivary glands of sand flies. Maxadilan TFA exhibits anti-apoptotic activity in hADSCs. Maxadilan TFA inhibits pro-inflammatory cytokines (TNF-α) and enhances anti-inflammatory mediators (IL-10). Maxadilan TFA can activate leukocytes and inhibit vascular permeability through PAC1 receptors. Maxadilan TFA promotes neural differentiation of human adipose-derived stem cells. Maxadilan TFA can be used to study endotoxin shock, atherosclerosis, and neurodegenerative diseases [1] [2] [3] [4] [5].
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BDL-E5
BDL-E5
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Cat. No.: HY-D3525
Target:  

Fluorescent Dye

Research Areas:  

Others

BDL-E5 is a fluorescent probe for detecting live induced pluripotent stem cells at the early reprogramming stage. Its detection mechanism involves specific binding to authentic reprogramming cells, which exhibit increased expression of pluripotency and epithelial genes and decreased expression of mesenchymal genes compared to non-reprogramming cells; it appears to co-localize more significantly with the Golgi complex than other organelle markers in reprogramming cells, and it does not require washing after staining to reduce background signals; fluorescence is generated upon binding to these early reprogramming cells, with positive cells appearing 7 days before iPS colonies are visible and stain positive for the conventional pluripotent marker TRA-1-60, and sorting BDL-E5-positive cells enriches populations that generate higher numbers and quality of iPS colonies. Its detection wavelength is Ex/Em = 578/599 nm .
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