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hydrolytic

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y0850E
    Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed)
    3 Publications Verification

    PVA (Mw 30000-70000, 87-90% hydrolyzed); Poly(Ethenol) (Mw 30000-70000, 87-90% hydrolyzed)

    		 Environmental Pollutants Biochemical Assay Reagents Cardiovascular Disease Cancer
    Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 30000-70000 and hydrolytic properties. The degree of hydrolysis refers to the degree to which the acetate groups in the original polyvinyl acetate are converted into hydroxyl groups during the hydrolysis process. Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. A degree of hydrolysis of 87-90% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipients .
    Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed)
  • HY-W018781
    Benzamidine hydrochloride
    3 Publications Verification

    		 Ser/Thr Protease Cancer
    Benzamidine hydrochloride is a competitive protease inhibitor that blocks the hydrolytic cleavage of glucagon by plasmin, trypsin and thrombin. Benzamidine hydrochloride effectively inhibits the degradation of glucagon by relevant proteases during the collection, storage and analysis of human plasma and blood samples. During in vivo metabolism, Benzamidine hydrochloride undergoes N-hydroxylation and produces multiple metabolites, exhibiting characteristics of delayed excretion or biphasic elimination. Benzamidine hydrochloride only induces slight single-strand DNA breaks at high concentrations and shows no significant genotoxic potential overall. Benzamidine hydrochloride may interfere with the detection of some glucagon antisera, but does not affect key antigen-antibody affinity at specific concentrations. Benzamidine hydrochloride can be used as a stabilizer in glucagon radioimmunoassays to ensure the accuracy and recovery rate of detection results .
    Benzamidine hydrochloride
  • HY-Y0850J
    Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed)
    3 Publications Verification

    PVA (Mw 13000-23000, 87-89% hydrolyzed); Poly(Ethenol) (Mw 13000-23000, 87-89% hydrolyzed)

    		 Environmental Pollutants Biochemical Assay Reagents Cancer
    Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 130000-23000 and hydrolytic properties. Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate and polyvinyl alcohol is obtained. A degree of hydrolysis of 87-89% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipient. Polyvinyl alcohol can be used in tissue engineering by electrospinning. Polyvinyl alcohol can achieve high cellular density, infiltration, and uniform distribution, facilitating functional connections between cells. Polyvinyl alcohol can improve cell vitality through in vitro cultivation. Polyvinyl alcohol demonstrates promising inhibition of ostersarcoma cancer cells with Doxorubicin (HY-15142A) .
    Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed)
  • HY-129217
    Naringinase
    2 Publications Verification

    		 Glycosidase Others
    Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase has wide occurrence in nature. Naringinase can be used in the biotransformation of steroids, antibiotics, and mainly on glycosides hydrolysis .
    Naringinase
  • HY-N1181
    Tamarixetin
    2 Publications Verification

    4'-O-Methyl Quercetin

    		 Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species (ROS) Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .
    Tamarixetin
  • HY-133668
    Monoethyl phthalate

    		Drug Metabolite Cytochrome P450 PPAR Endocrinology Cancer
    Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms .
    Monoethyl phthalate
  • HY-Y0850L
    Polyvinyl alcohol (Mw 85000-124000, 99+% hydrolyzed)
    3 Publications Verification

    PVA (Mw 85000-124000, 99+% hydrolyzed); Poly(Ethenol) (Mw 85000-124000, 99+% hydrolyzed)

    		 Environmental Pollutants Biochemical Assay Reagents Cancer
    Polyvinyl alcohol (Mw 85000-124000, 99+% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 85000-124000 and hydrolytic properties. Polyvinyl alcohol (Mw 85000-124000, 99+% hydrolyzed) forms hydrogels that can be used to simulate digestive organs and lesion models for the training of endoscopic ultrasound (EUS) and endoscopic ultrasound elastography (EUS-E). Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipients .
    Polyvinyl alcohol (Mw 85000-124000, 99+% hydrolyzed)
  • HY-Y0850M
    Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed)
    3 Publications Verification

    PVA (Mw 85000-124000, 87-89% hydrolyzed); Poly(Ethenol) (Mw 85000-124000, 87-89% hydrolyzed)

    		 Environmental Pollutants Biochemical Assay Reagents Others
    Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 85000-124000 and hydrolytic properties. The degree of hydrolysis refers to the degree to which the acetate groups in the original polyvinyl acetate are converted into hydroxyl groups during the hydrolysis process. Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. A degree of hydrolysis of 87-89% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipient .
    Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed)
  • HY-Y0850P
    Polyvinyl alcohol (Mw 146000-186000, 87-89% hydrolyzed)
    3 Publications Verification

    PVA (Mw 146000-186000, 87-89% hydrolyzed); Poly(Ethenol) (Mw 146000-186000, 87-89% hydrolyzed)

    		 Environmental Pollutants Biochemical Assay Reagents Cancer
    Polyvinyl alcohol (Mw 146000-186000, 87-89% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 146000-186000 and hydrolytic properties. Polyvinyl alcohol (Mw 146000-186000, 87-89% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipient. Polyvinyl alcohol can be used in tissue engineering by electrospinning. Polyvinyl alcohol can achieve high cellular density, infiltration, and uniform distribution, facilitating functional connections between cells. Polyvinyl alcohol can improve cell vitality through in vitro cultivation. Polyvinyl alcohol demonstrates promising inhibition of ostersarcoma cancer cells with Doxorubicin (HY-15142A) .
    Polyvinyl alcohol (Mw 146000-186000, 87-89% hydrolyzed)
  • HY-W009004
    Trilysine

    Lys-Lys-Lys; H-Lys-Lys-Lys-OH

    		 Biochemical Assay Reagents Others
    Trilysine is a tripeptide and also a substrate for specific peptidases. Trilysine serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP .
    Trilysine
  • HY-12798C
    AR-13503

    AR-13324 M1 metabolite

    		 PKC ROCK Cardiovascular Disease Neurological Disease
    AR-13503 (AR-13324 M1 metabolite) is the hydrolytic metabolite of AR-13324 mesylate. AR-13324 is a ROCK kinase and PKC inhibitor with anti-angiogenic and retinal health-improving effects, showing potential for use in retinal disease research .
    AR-13503
  • HY-N0886
    Aloin B
    3 Publications Verification

    Isobarbaloin

    		 SARS-CoV Virus Protease Infection Endocrinology Cancer
    Aloin B (Isobarbaloin) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC50 of 16.08 μM (hydrolytic activity) and 17.51 μM (deubiquitinase activity). Aloin B is metabolized by rat intestinal flora into aloe-emodin-9-anthrone to exert laxative effects. Aloin B inhibits TPA (HY-18739)-induced ear edema, putrescine elevation, and tumor promotion in mouse skin. Aloin B can be used in research related to anti-inflammation, tumor promotion inhibition, coronavirus disease 2019 (COVID-19) and constipation .
    Aloin B
  • HY-125913
    Benzamidine
    3 Publications Verification

    		 Ser/Thr Protease Inflammation/Immunology
    Benzamidine is a competitive protease inhibitor that blocks the hydrolytic cleavage of glucagon by plasmin, trypsin and thrombin. Benzamidine effectively inhibits the degradation of glucagon by relevant proteases during the collection, storage and analysis of human plasma and blood samples. During in vivo metabolism, Benzamidine undergoes N-hydroxylation and produces multiple metabolites, exhibiting characteristics of delayed excretion or biphasic elimination. Benzamidine only induces slight single-strand DNA breaks at high concentrations and shows no significant genotoxic potential overall. Benzamidine may interfere with the detection of some glucagon antisera, but does not affect key antigen-antibody affinity at specific concentrations. Benzamidine can be used as a stabilizer in glucagon radioimmunoassays to ensure the accuracy and recovery rate of detection results .
    Benzamidine
  • HY-P2895
    Clostripain

    Clostridiopeptidase B

    		 Endogenous Metabolite Others
    Clostripain (Clostridiopeptidase B) is a thiol protease isolated from Clostridium histolyticum. Clostripain exhibits proteolytic activity as well as amidase-esterase activity. The specificity of Clostripain is primarily restricted to arginine residues, but it also shows minor hydrolytic activity toward most lysine-containing substrates. Clostripain catalyzes the ammonolysis of Carbobenzoxyarginyl methyl ester to generate various dipeptides .
    Clostripain
  • HY-Y0850U9
    PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization)

    Polyvinyl alcohol (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization); Poly(Ethenol) (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization)

    		 Biochemical Assay Reagents Others
    PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization) is a polyvinyl alcohol with a molecular weight of 67000 and hydrolytic properties. Degree of hydrolysis refers to the conversion rate of acetate groups in the original polyvinyl acetate to hydroxyl groups; PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization) is obtained by hydrolyzing and removing acetate groups after the polymerization of vinyl acetate. Polyvinyl alcohol with different degrees of hydrolysis can be used to form self-crosslinked cryogels and is applied as a biological adjuvant .
    PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization)
  • HY-P2893B
    Creatinase, microorganism

    Creatine amidinohydrolase, microorganism

    		 Endogenous Metabolite Metabolic Disease
    Creatine amidinohydrolase, microorganism is a hydrolytic enzyme that catalyzes the hydrolysis of creatine into creatinine and urea, playing a crucial role in the measurement of creatinine concentration. Creatine amidinohydrolase, microorganism can be used in the development of biosensors for measuring serum creatinine levels .
    Creatinase, microorganism
  • HY-178208
    MDOLL-0286

    		Poly(ADP-ribose) Glycohydrolase (PARG) Cancer
    MDOLL-0286 is a selective Poly(ADP-ribose) Glycohydrolase (PARG) (ARH3) inhibitor with an IC50 of 2.3μM. MDOLL-0286 can inhibit ARH3’s poly-ADP-ribose hydrolytic activity on cellular substrates. MDOLL-0286 can inhibit DNA damage response. MDOLL-0286 can be used for the research of cancer .
    MDOLL-0286
  • HY-P2950
    α-Mannosidase

    		Glycosidase Metabolic Disease
    α-Mannosidase is a hydrolytic enzyme targeting mannose-containing glycoproteins or glycolipids. α-Mannosidase is promising for research of inherited α-mannosidosis .
    α-Mannosidase
  • HY-N10418
    Isorhapontin

    		Fungal Infection
    Isorhapontin is an antifungal agent. Isorhapontin inhibits the hydrolytic activity of Trichoderma cellobiohydrolase I (CBH I) with a Ki of 57.2 μM. Isorhapontin also inhibits the activity of Trichoderma endoglucanase I .
    Isorhapontin
  • HY-W087937
    Benzamidine hydrochloride hydrate
    3 Publications Verification

    Benzenecarboximidamide hydrochloride hydrate

    		 Ser/Thr Protease Cancer
    Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a competitive protease inhibitor that blocks the hydrolytic cleavage of glucagon by plasmin, trypsin and thrombin. Benzamidine hydrochloride hydrate effectively inhibits the degradation of glucagon by relevant proteases during the collection, storage and analysis of human plasma and blood samples. During in vivo metabolism, Benzamidine hydrochloride hydrate undergoes N-hydroxylation and produces multiple metabolites, exhibiting characteristics of delayed excretion or biphasic elimination. Benzamidine hydrochloride hydrate only induces slight single-strand DNA breaks at high concentrations and shows no significant genotoxic potential overall. Benzamidine hydrochloride hydrate may interfere with the detection of some glucagon antisera, but does not affect key antigen-antibody affinity at specific concentrations. Benzamidine hydrochloride hydrate can be used as a stabilizer in glucagon radioimmunoassays to ensure the accuracy and recovery rate of detection results .
    Benzamidine hydrochloride hydrate
  • HY-108960
    PPADS

    		P2X Receptor Interleukin Related Neurological Disease
    PPADS is a P2X receptor (P2X Receptor) antagonist and a reversible competitive antagonist of NAADP receptors, with IC50 values of 68 nM (P2X1) and 214 nM (P2X3), respectively. PPADS alleviates pain-related behaviors in the central and peripheral nervous systems of mice after peripheral neuropathy, inhibits the overproduction of IL-1β, IL-6, iNOS and nNOS, and suppresses the hydrolytic activity of extracellular ATPase. PPADS blocks ATP-mediated inward currents on recombinant rat P2X1 and P2X3 receptors, and inhibits purinergic nerve stimulation-induced contraction of rabbit bladder detrusor muscle. PPADS is applicable to research related to neuropathic pain .
    PPADS
  • HY-W004812
    BOC-(1R,3S)-3-aminocyclopentane carboxylic acid

    (1S,3S)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid

    		 Drug Intermediate SARS-CoV Infection
    BOC-(1R,3S)-3-aminocyclopentane carboxylic acid ((1S,3S)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid) is a conformationally constrained peptide building block and a key component of SARS-CoV-2 main protease (Mpro) inhibitors. When incorporated into macrocyclic peptides, BOC-(1R,3S)-3-aminocyclopentane carboxylic acid not only helps generate high-affinity Mpro inhibitors by preorganizing the secondary structure of peptides, but also exerts sequence-dependent functional inhibition on the hydrolytic activity of Mpro. BOC-(1R,3S)-3-aminocyclopentane carboxylic is widely used in COVID-19-related research .
    BOC-(1R,3S)-3-aminocyclopentane carboxylic acid
  • HY-P4468
    Lys-Ala-pNA

    		Dipeptidyl Peptidase Others
    Lys-Ala-pNA is hydrolytic substrate the of dipeptidyl peptidase (DPP) II with Km of 0.42 mM .
    Lys-Ala-pNA
  • HY-Y0850U7
    PVA (Mw 195000, 98-99% hydrolyzed, ~4300 polymerization)

    Polyvinyl alcohol (Mw 195000, 98-99% hydrolyzed, ~4300 polymerization); Poly(Ethenol) (Mw 195000, 98-99% hydrolyzed, ~4300 polymerization)

    		 Biochemical Assay Reagents Others
    PVA (Mw 195000, 98-99% hydrolyzed, ~4300 polymerization) is polyvinyl alcohol with a molecular weight of 195,000 and hydrolytic properties. PVA (Mw 195000, 98-99% hydrolyzed, ~4300 polymerization) is obtained by polymerizing vinyl acetate followed by hydrolysis to remove acetate groups, yielding polyvinyl alcohol .
    PVA (Mw 195000, 98-99% hydrolyzed, ~4300 polymerization)
  • HY-P2648
    Suc-Ala-Ala-Pro-Leu-pNA

    N-Succinyl-AAPL-p-nitroanilide

    		 Aminopeptidase Endocrinology
    Suc-Ala-Ala-Pro-Leu-pNA (N-Succinyl-AAPL-p-nitroanilide) is a tripeptidyl p-nitroanilide substrate that can be catalytically hydrolyzed by acyl amidase-like leucine aminopeptidase in seminal plasma. Amastatin (HY-129298) and Actinonin (HY-113952) exert potent inhibitory effects on this hydrolytic activity. Suc-Ala-Ala-Pro-Leu-pNA can be used for the research of diseases such as azoospermia .
    Suc-Ala-Ala-Pro-Leu-pNA
  • HY-P10053
    sPLA2-IIA Inhibitor

    		Phospholipase Metabolic Disease
    sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .
    sPLA2-IIA Inhibitor
  • HY-P2769A
    Thermostable β-Agarase

    		Biochemical Assay Reagents Others
    Thermostable β-Agarase is a hydrolase that can hydrolyze the β-1,4 linkages in agarose to produce neoagaro-oligosaccharides, and it can be used to extract DNA and RNA from gels. Compared to conventional β-Agarase, Thermostable β-Agarase exhibits higher heat resistance and stronger hydrolytic activity. The thermostable properties of Thermostable β-Agarase simplify experimental procedures and make it suitable for the rapid purification of intact large DNA molecules .
    Thermostable β-Agarase
  • HY-W010115
    Carbofuran phenol

    		Environmental Pollutants Drug Metabolite Others
    Carbofuran phenol is a hydrolytic metabolite of the Carbofuran pesticide. Carbofuran phenol is promising for research of environmental bioremediation fields .
    Carbofuran phenol
  • HY-404548
    Sulfo-TAG TFP ester disodium

    		Biochemical Assay Reagents Others
    Sulfo-TAG TFP ester disodium is a tetrafluorophenyl (TFP) ester that can be coupled to proteins via primary amine groups. Sulfo-TAG TFP ester disodium is more hydrophobic than NHS esters and exhibits higher hydrolytic stability in aqueous solutions. Sulfo-TAG TFP ester disodium can be used for antibody labeling.
    Sulfo-TAG TFP ester disodium
  • HY-N1181R
    Tamarixetin (Standard)

    4'-O-Methyl Quercetin (Standard)

    		 Reference Standards Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species (ROS) Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Tamarixetin (Standard) is the analytical standard of Tamarixetin. This product is intended for research and analytical applications. Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .
    Tamarixetin (Standard)
  • HY-135886
    2-Nitrophenyl α-D-galactopyranoside

    		Biochemical Assay Reagents Others
    2-Nitrophenyl α-D-galactopyranoside, a nitrophenyl derivative, is a substrate to test for hydrolytic activity of glycosyl hydrolase .
    2-Nitrophenyl α-D-galactopyranoside
  • HY-W354821
    4-Methylumbelliferyl Decanoate

    4-MUD

    		 Fluorescent Dye Metabolic Disease
    4-Methyl-2-oxo-2H-1-benzopyran-7-yl decanoate is a fluorogenic substrate used to follow the hydrolytic activity of carboxylesterases .
    4-Methylumbelliferyl Decanoate
  • HY-163169
    Phenyl-glutarimide 4'-oxyacetic acid

    		Ligands for E3 Ligase Others
    Phenyl-glutarimide 4 ’-oxyacetic acid is a carboxylic acid-functionalized cerebellar ligand that can be used in the development of PROTAC deactivators. Phenyl-glutarimide 4 ’-oxyacetic acid binds to PROTAC has better hydrolytic stability and efficacy .
    Phenyl-glutarimide 4'-oxyacetic acid
  • HY-116033
    BMS-363131

    		Ser/Thr Protease Inflammation/Immunology
    BMS-363131 is a selective inhibitor for tryptase, with an IC50 <1.7 nM. BMS-363131 is hydrolytic stable at pH=7 and pH=9. BMS-363131 attenuates the astham in a guinea pig model .
    BMS-363131
  • HY-P2939
    Chondroitinase AC

    		Apoptosis Biochemical Assay Reagents Cancer
    Chondroitinase AC is a hydrolytic enzyme. Chondroitinase AC degrades chondroitin sulfate A and chondroitin sulfate C. Chondroitinase AC inhibits the invasion and proliferation of melanoma cells and endothelial cells, and increases apoptosis. Chondroitinase AC can be used in research on melanoma and other cancers .
    Chondroitinase AC
  • HY-P2781
    3′,5′-Cyclic nucleotide phosphodiesterase

    		Phosphodiesterase (PDE) Cardiovascular Disease Neurological Disease Inflammation/Immunology
    3′,5′-Cyclic nucleotide phosphodiesterase is a hydrolytic enzyme that degrades cyclic 3', 5' -adenosine monophosphate (cyclic AMP). 3′,5′-Cyclic nucleotide phosphodiesterase is promising for research of cardiovascular diseases, inflammation, central nervous system disorders, and metabolic syndrome .
    3′,5′-Cyclic nucleotide phosphodiesterase
  • HY-120195
    PF-04677490

    		Phosphodiesterase (PDE) Neurological Disease
    PF-04677490 is a PDE1 inhibitor (IC50: 21 nM). PF-04677490 has IC50s of 21 nM, 83 nM, and 118 nM for PDE1B1, PDE1C, and PDE1A, respectively. PF-04677490 efficaciously inhibits cAMP- and cGMP-hydrolytic activity .
    PF-04677490
  • HY-P2815
    Creatinine deiminase

    		Biochemical Assay Reagents Others
    Creatinine deiminase is a hydrolytic enzyme. Creatinine deiminase plays a crucial role in the conversion of the metabolic waste creatinine into creatine. Creatinine deiminase is a creatine bioanalytical tool. Creatinine deiminase can be used to construct a novel creatinine-sensitive biosensor when adsorbed on a silicate-modified pH-sensitive field-effect transistor (pH-FET) .
    Creatinine deiminase
  • HY-W856819
    Eseroline

    		Opioid Receptor Cholinesterase (ChE) Drug Metabolite nAChR Neurological Disease
    Eseroline is a potent μ-opioid receptor agonist, which is the hydrolytic metabolite of Physostigmine (HY-N6608). Eseroline is a selective and competitive acetylcholinesterase (AChE) inhibitor, with its Ki values for AChE and BuChE being 0.1 μM and 200 μM respectively. Eseroline has nicotinic acetylcholine receptor allosteric enhancing ligand (nAChR-APL) activity, meaning it does not activate the receptor but significantly enhances the signal transduction of Ach triggered by the receptor. Eseroline is neurotoxic, causing cell membrane damage (LDH leakage) and energy metabolism collapse (ATP depletion). Eseroline can be used for the study of Alzheimer's disease .
    Eseroline
  • HY-131824
    5,6-DM-cBIMP

    		Phosphodiesterase (PDE) Others
    5,6-DM-cBIMP, a cyclic nucleotide analog, is an agonist of PDE2 that can significantly enhance the cAMP and cGMP hydrolytic activities of PDE2 [2.
    5,6-DM-cBIMP
  • HY-131823
    5,6-DCl-cBIMP

    		Phosphodiesterase (PDE) Others
    5,6-DCl-cBIMP, a cyclic adenosine monophosphate analog, can act as an agonist of PDE2 and significantly enhance the cAMP and cGMP hydrolytic activities of PDE2 .
    5,6-DCl-cBIMP
  • HY-138152
    Z-D-Arg-Gly-Arg-pNA dihydrochloride

    Benzyl-D-Arg-Gly-Arg-pNA dihydrochloride

    		 Fluorescent Dye Others
    Z-D-Arg-Gly-Arg-pNA dihydrochloride is a hydrolytic chromogenic plasmin substrate .
    Z-D-Arg-Gly-Arg-pNA dihydrochloride
  • HY-W704138
    2-Hydroxy-atrazine

    		Endogenous Metabolite Drug Derivative Others
    2-Hydroxy-atrazine is a non-herbicidal primary photoproduct that results from the hydrolytic dechlorination of atrazine.
    2-Hydroxy-atrazine
  • HY-P10615
    Abz-YGGRASDQ-EDDnp

    		Fluorescent Dye Transthyretin (TTR) Others
    Abz-YGGRASDQ-EDDnp is a fluorescent substrate of transthyretin (TTR) protein and is used to detect the hydrolytic activity of TTR protein .
    Abz-YGGRASDQ-EDDnp
  • HY-W009004B
    Trilysine TFA

    Lys-Lys-Lys TFA; H-Lys-Lys-Lys-OH TFA

    		 Biochemical Assay Reagents Others
    Trilysine TFA is a tripeptide and also a substrate for specific peptidases. Trilysine TFA serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP .
    Trilysine TFA
  • HY-108828
    Alglucosidase alfa

    rhGAA

    		 Glycosidase Metabolic Disease
    Alglucosidase alfa (rhGAA) is a hydrolytic lysosomal glycogen-specific recombinant human α-glucosidase. Alglucosidase alfa can be used for Pompe disease research .
    Alglucosidase alfa
  • HY-W704138R
    2-Hydroxy-atrazine (Standard)

    		Endogenous Metabolite Reference Standards Others
    2-Hydroxy-atrazine (Standard) is the analytical standard of 2-Hydroxy-atrazine. This product is intended for research and analytical applications. 2-Hydroxy-atrazine is a non-herbicidal primary photoproduct that results from the hydrolytic dechlorination of atrazine.
    2-Hydroxy-atrazine (Standard)
  • HY-W591969
    Benzyl (6-oxohexyl)carbamate

    		Biochemical Assay Reagents Others
    Benzyl (6-oxohexyl)carbamate is a linker containing an aldehyde group and a benzyl (Cbz) protecting group. The aldehyde can react with hydrazine or hydrazide to form a hydrolytic acyl hydrozone linkage. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
    Benzyl (6-oxohexyl)carbamate
  • HY-134283
    8-Benzylthio-cAMP

    		PKA Apoptosis Others
    8-Benzylthio-cAMP is a derivative of cyclic adenosine monophosphate (cAMP). 8-Bn-cAMP is a site-selective activator of cAMP-dependent protein kinases. Compared with cyclic adenosine monophosphate, it is more stable to phosphodiesterase (PDE) hydrolysis and has higher membrane permeability. 8-Bn-cAMP can be used to study the role of cAMP in regulating cell proliferation, differentiation and apoptosis .
    8-Benzylthio-cAMP
  • HY-131842
    6-Bn-cAMP

    N6-Benzyladenosine-3',5'-cyclic monophosphate

    		 PKA Cancer
    6-Bn-cAMP is a site-selective activator of cAMP-dependent protein kinase (PKA) which does not activate Epac. 6-Bn-cAMP increases hydrolytic stability against PDE, esterases, amidases and considerably higher membrane permeability compared to cAMP .
    6-Bn-cAMP

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