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juvenile

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Androgen Receptor (1) Apoptosis (2) Autophagy (3) Bacterial (2) Biochemical Assay Reagents (3) c-Met/HGFR (1) Cannabinoid Receptor (1) CaSR (1) CRFR (2) Cytochrome P450 (1) Dopamine Receptor (2) Drug Derivative (1) Drug Isomer (1) Drug Metabolite (2) Endogenous Metabolite (3) Environmental Pollutants (5) ERK (2) Estrogen Receptor/ERR (1) Farnesyl Transferase (1) Fungal (2) GABA Receptor (1) Glucocorticoid Receptor (1) Histone Demethylase (2) Insecticide (9) Isotope-Labeled Compounds (5) JAK (1) Melanocortin Receptor (2) mGluR (2) mRNA (1) NF-κB (2) NO Synthase (2) Parasite (11) Phosphatase (2) Porcupine (2) Potassium Channel (1) Progesterone Receptor (5) Ras (1) Reactive Oxygen Species (ROS) (2) Reference Standards (3) Salt-inducible Kinase (SIK) (1) SARS-CoV (1) SHP2 (2) SOD (1) STAT (1) TNF Receptor (1) Topoisomerase (1) β-catenin (1)
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108847

Etanercept 10+ Cited Publications	TNF Receptor Bacterial	Inflammation/Immunology Cancer
Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis .

HY-N0176

Dihydroartemisinin 40+ Cited Publications Dihydroqinghaosu; β-Dihydroartemisinin; Artenimol	Parasite NF-κB Autophagy Reactive Oxygen Species (ROS) Drug Metabolite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection .

HY-B1161

Methoprene 10+ Cited Publications ZR-515	Environmental Pollutants Insecticide	Others
Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist .

HY-P99207

Lenzilumab 1 Publications Verification KB 003	SARS-CoV	Cancer
Lenzilumab (KB 003) is a human monoclonal antibody targeting CSF2/GM-CSF for COVID-19, chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) studies .

HY-108786

Asfotase alfa ENB-0040	Phosphatase	Metabolic Disease
Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2 ^/ knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP) .

HY-B1161A

S-Methoprene 2 Publications Verification (+)-Methoprene; (7S)-Methoprene	Environmental Pollutants Cannabinoid Receptor	Others
S-Methoprene is an insect juvenile hormone analog and effective insecticide that blocks the transition from pupa to adult. S-Methoprene is also a CB(1) receptor ligand and inhibits the binding of the CB1 receptor antagonist [ ³H]CP-55940 to the CB1 receptor (IC₅₀: 19.31 μM) .

HY-69019

7-Nitroindazole 1 Publications Verification	NO Synthase	Cardiovascular Disease Neurological Disease
7-Nitroindazole is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS) (IC₅₀ = 0.47 μM in mouse cerebellum). 7-Nitroindazole does not affect blood pressure or endothelium-dependent relaxation while inhibiting nNOS in experimental animals. 7-Nitroindazole has anti-injurious and neuroprotective properties, and can be studied in research for neurological diseases such as Parkinson’s disease .

HY-B1095

Chlormadinone acetate 1 Publications Verification	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor GABA Receptor	Neurological Disease Metabolic Disease
Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .

HY-N9599

Roridin A	Fungal Endogenous Metabolite Parasite Insecticide	Infection
Roridin A acts as an inhibitor of pollen development in Arabidopsis thaliana and nematicide. Roridin A is isolated from the fungus Cylindrocarpon sp. Roridin A delays the flowering time of Arabidopsis thaliana, inhibits pollen development and stem elongation, and blocks plant growth. Roridin A induces larval death of the southern root-knot nematode (Meloidogyne incognita) .

HY-B2031

Pyriproxyfen 1 Publications Verification S-31183	Environmental Pollutants Autophagy Parasite	Infection
Pyriproxyfen is a juvenile hormone analog and insect growth regulator. Pyriproxyfen is used in research related to dengue fever and malaria .

HY-N7240

*(Rac)-Juvenile* hormone III**	Others	Metabolic Disease
(Rac)-Juvenile hormone III is a *cecropia juvenile* hormone** and juvenile hormone agonist. (Rac)-Juvenile hormone III induces test insects to retain larval characteristics after the final molt to the adult stage. (Rac)-Juvenile hormone III exhibits juvenile hormone activity in Tenebrio molitor pupae and last-instar nymphs of Oncopeltus fasciatus. (Rac)-Juvenile hormone III possesses morphogenetic activity in insect assays .

HY-15825

IWP L6 4 Publications Verification Porcn Inhibitor III	Porcupine	Cancer
IWP L6 (Porcn Inhibitor III) is a Porcupine (Porcn) inhibitor with an EC₅₀ of 0.5 nM. IWP L6 disrupts well-established Wnt-dependent developmental processes of embryonic and juvenile zebrafish .

HY-100371

(RS)-MCPG 1 Publications Verification alpha-MCPG	mGluR	Neurological Disease
(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons .

HY-P0060

Tetracosactide Tetracosactrin; ACTH(1–24)	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-P0060A

Tetracosactide acetate Tetracosactrin acetate; ACTH(1–24) acetate	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide acetate (Tetracosactrin acetate ) is the acetate salt form of Tetracosactide (HY-P0060). Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-W017960

Diludine Et-HE; 1,4-DHP	SOD	Endocrinology
Diludine (BNP-7787) is an orally effective feed additive. Diludine reduces the activity of G6PD and increases the level of superoxide dismutase (SOD). Diludine reduces the mutagenic effect of environmental pollutants, protects parental reproductive systems and improves offspring quality. Diludine is mainly applied during the transition period of dairy cows to increase milk yield and milk fat content, and improve health status during parturition. Diludine can be used in animal feeding research .

HY-B1017

Molindone (hydrochloride) EN-1733A	Dopamine Receptor	Neurological Disease
Molindone hydrochloride (EN-1733A) is an orally active and brain-penetrant dopamine D2/D5 receptor antagonist. Molindone hydrochloride shows antipsychotic and antidepressant-like activities. Molindone hydrochloride suppresses spontaneous locomotion, and antagonizes apomorphine-induced emesis. Molindone hydrochloride can be used for the research of neurological disease .

HY-N3340

Macrocarpal I	Fungal	Infection
Macrocarpal I is a phloroglucinol coupled sesquiterpenoid with antifungal activity. Macrocarpal I against C. glabrata with an IC₅₀ value of 0.75 μg/mL. Macrocarpal I can be isolated from the juvenile leaves of E. maideni .

HY-W014566

4-Nitro-3-(trifluoromethyl)phenol 3-(Trifluoromethyl)-4-Nitrophenol; TFM	Environmental Pollutants Cytochrome P450 Insecticide	Infection
4-Nitro-3-(trifluoromethyl)phenol (TFM) is a piscicide that is toxic to lampreys (P. marinus) (LC₅₀ values are 1.97-2.11 for cysts, 2.05-2.21 for fry, 1.6-2.45 for juveniles, and 1.6-1.63 for adults, respectively). 4-Nitro-3-(trifluoromethyl)phenol is also toxic to juvenile lake sturgeons (A. fulvescens) less than 100 mm, but is nontoxic to a variety of other fish species. 4-Nitro-3-(trifluoromethyl)phenol (50 μM) dissociates oxidative phosphorylation by 22% and 28% in isolated livers of lampreys and rainbow trout (O. mykiss), respectively. 4-Nitro-3-(trifluoromethyl)phenol can be used to control lamprey larval populations.

HY-122062

Fenoxycarb 1 Publications Verification	Environmental Pollutants Insecticide	Others
Fenoxycarb, a juvenile hormone, is an insecticide and can be used for agricultural pest control .

HY-N7240S

*(Rac)-Juvenile* Hormone III-d3**	Isotope-Labeled Compounds Others	Others
Juvenile Hormone III-d₃ is the deuterium labeled Juvenile Hormone III. (Rac)-Juvenile Hormone III is a *cecropia juvenile* hormone** and juvenile hormone agonist. (Rac)-Juvenile Hormone III induces test insects to retain larval characteristics after the final molt to the adult stage. (Rac)-Juvenile Hormone III exhibits juvenile hormone activity in Tenebrio molitor pupae and last-instar nymphs of Oncopeltus fasciatus. (Rac)-Juvenile Hormone III possesses morphogenetic activity in insect assays .

HY-123897

Chamaejasmenin C	Parasite	Infection
Chamaejasmenin C, a biflavanone, shows nematicidal activity against second-stage juveniles (J2s) of B. xylophilus and B. mucronatus .

HY-P1882

Type A Allatostatin I	Insecticide	Inflammation/Immunology
Type A Allatostatin I is a tridecapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

HY-N8392

Ascr#9	Parasite	Infection
Ascr#9 is a small-molecule pheromone belonging to the ascaroside family, and it is widely present in nematodes. Ascr#9 promotes dispersal or elicits avoidance behavior in various nematode species (such as Caenorhabditis elegans and entomopathogenic nematodes), suggesting that individuals evacuate from adverse environments. Ascr#9 exhibits repellent potential in Meloidogyne incognita .

HY-B1161R

Methoprene (Standard) ZR-515 (Standard)	Insecticide Reference Standards	Others
Methoprene (Standard) is the analytical standard of Methoprene. This product is intended for research and analytical applications. Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist .

HY-175184

LSD1-IN-44	Histone Demethylase	Infection
LSD1-IN-44 (Compound 19) is a LSD1 inhibitor with an IC₅₀ of 0.02  μM for LSD1-CoREST enzymatic complex. LSD1-IN-44 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. LSD1-IN-44 has no significant toxicity to human cells. LSD1-IN-44 can be used for schistosomiasis research .

HY-P1786

Allatostatin II	Potassium Channel	Neurological Disease
Allatostatin II is a decapeptid. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

HY-120044

L-739749	Farnesyl Transferase Ras	Cancer
L-739749 is a farnesyl transferase inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro .

HY-W587689

Juvenile hormone B 3 (mixture of diastereomers) juvenile hormone III bisepoxide; juvenile hormone bisepoxide; JHB3	c-Met/HGFR	Others
Juvenile hormone B 3 (Juvenile hormone III bisepoxide)(mixture of diastereomers) is a sesquiterpenoid hormone. Juvenile hormone B 3 can be isolated from corpus allatum (CA) of high dipterans like the fruitfly and Drosophila melanogaster. JHB3 has anti-metamorphic activity and induces Kr-h1 expression by directly interacting with juvenile hormone (JH) receptors (Met and Gce). Juvenile hormone B 3 can be used for insect lethality research .

HY-125257

SHP2 inhibitor LY6 LY6	Phosphatase SHP2 ERK Akt STAT JAK Apoptosis	Cancer
SHP2 inhibitor LY6 (LY6) is a selective SHP2 inhibitor with an IC₅₀ of 9.8 μM, showing 7-fold selectivity over SHP1. SHP2 inhibitor LY6 inhibits SHP2-mediated cell signaling pathways and suppresses cell proliferation. SHP2 inhibitor LY6 elicits induces apoptosis and G2/M cell cycle arrest in lung cancer cells. SHP2 inhibitor LY6 can be used for the research of B cell acute lymphoblastic leukemia, acute myeloid leukemia, and lung cancer .

HY-P5866

Allatotropin Manse-AT	Endogenous Metabolite	Endocrinology
Allatotropin (Manse-AT) is a 13 amino acid neuropeptide. Allatotropin activates inositol 1,4,5-trisphosphate (IP3) pathway, and the biosynthesis of juvenile hormone (JH) in Manduca sexta .

HY-122530

Juvocimene I	Insecticide	Endocrinology
Juvocimene I is a potent juvenile hormone mimic. Juvocimene I can be isolated from the essential oil of sweet basil,Ocimum basilicum L .

HY-175185

MC3935	Histone Demethylase	Infection
MC3935 is a LSD1 inhibitor with an IC₅₀ of 0.52  μM for LSD1-CoREST enzymatic complex. MC3935 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. MC3935 has no significant toxicity to human cells. MC3935 can be used for schistosomiasis research .

HY-175803

SHP2-IN-44	SHP2 ERK	Cancer
SHP2-IN-44 (Compound 26) is an allosteric and orally active SHP2 inhibitor with an IC₅₀ of 27 ?nM. SHP2-IN-44 also inhibits ERK phosphorylation (IC₅₀ of 299 ?nM) without off-target hERG activity. SHP2-IN-44 has a broad-spectrum anticancer activity, such as juvenile myelomonocytic leukemia, neuroblastoma and breast cancer. SHP2-IN-44 can be used for Noonan syndrome, LEOPARD syndrome and cancers research .

HY-B1161S

Methoprene-d7 ZR-515-d₇	Isotope-Labeled Compounds	Others
Methoprene-d₇ is the deuterium labeled Methoprene . Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist .

HY-P1760

Allatostatin IV	Insecticide	Neurological Disease
Allatostatin IV is an octapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

HY-P0001

Thymus factor X TFX-Jelfa	Biochemical Assay Reagents	Inflammation/Immunology
Thymic factor X (TFX-Jelfa) is an aqueous extract from juvenile calf thymuses and a natural stimulator of lymphocyte function .

HY-P4989

Type A Allatostatin III	Biochemical Assay Reagents	Infection
Type A Allatostatin III (allatostatin 3) is a blood-brain barrier permeable and reversible neuropeptide that inhibits hormone synthesis in juvenile female cockroaches. Type A Allatostatin III can be used in pesticide research .

HY-105294

FR 64822	Dopamine Receptor	Others
FR 64822 is a dopamine D2 receptor agonist that can induce antinociceptive activity in rats and mice by indirectly stimulating dopamine D2 receptors. FR 64822 can promote penile erection in juvenile rats and improve amnesia in rats induced by scopolamine during passive avoidance tasks .

HY-P10390

Insecticidal agent 11	Parasite	Infection
Insecticidal agent 11 (compound Q6) is a potent insect growth regulator (IGR)-based insecticide. Insecticidal agent 11 shows high insecticidal activity against Diploptera punctata by inhibiting juvenile hormone (JH) biosynthesis. Insecticidal agent 11 also exhibits insecticidal activity against Plutella xylostella .

HY-69019A

7-Nitroindazole sodium	NO Synthase	Cardiovascular Disease Neurological Disease
7-Nitroindazole sodium is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS). 7-Nitroindazole sodium can inhibit the activity of central NOS with an IC₅₀ of 0.47 μM in the cerebellum of mice. 7-Nitroindazole sodium has anti-injurious and neuroprotective properties .

HY-100371R

(RS)-MCPG (Standard) alpha-MCPG (Standard)	Reference Standards mGluR	Neurological Disease
(RS)-MCPG (Standard) is the analytical standard of (RS)-MCPG. This product is intended for research and analytical applications. (RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons .

HY-174600

Human IL6 mRNA	mRNA	Inflammation/Immunology
Human IL6 mRNA encodes the human interleukin 6 (IL6) protein, a cytokine that functions in inflammation and the maturation of B cells. IL6 has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.

HY-15825G

IWP L6 Porcn Inhibitor III	Porcupine	Cancer
IWP L6 (GMP) (Porcn Inhibitor III (GMP)) is IWP L6 (HY-15825) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IWP L6 (Porcn Inhibitor III) is a Porcupine (Porcn) inhibitor with an EC₅₀ of 0.5 nM. IWP L6 disrupts well-established Wnt-dependent developmental processes of embryonic and juvenile zebrafish .

HY-B1095S1

Chlormadinone acetate-d6-1	Isotope-Labeled Compounds Progesterone Receptor	Neurological Disease Metabolic Disease
Chlormadinone acetate-d₆-1 is deuterium labeled Chlormadinone acetate (HY-B1095). Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .

HY-B1095R

Chlormadinone acetate (Standard)	Reference Standards Progesterone Receptor	Neurological Disease Metabolic Disease
Chlormadinone acetate (Standard) is the analytical standard of Chlormadinone acetate (HY-B1095). This product is intended for research and analytical applications. Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders.

HY-B1095S2

Chlormadinone acetate-d3	Isotope-Labeled Compounds Progesterone Receptor	Neurological Disease Metabolic Disease
Chlormadinone acetate-d₃ is the deuterium labeled Chlormadinone acetate (HY-B1095). Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .

HY-16290

Lonaprisan ZK 230211; BAY86 5044	Progesterone Receptor	Endocrinology
Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC₅₀ of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect .

HY-173264

SDH-IN-24	Parasite Insecticide	Infection
SDH-IN-24 (Compound 51) is an inhibitor of succinate dehydrogenase (SDH). The LC50 against the second-stage juveniles of Bursaphelenchus xylophilus (B. xylophilus) is 6.9 mg/L, and the IC₅₀ for SDH is 15.0 μM. SDH-IN-24 exerts its nematicidal activity by inhibiting the activity of SDH to interfere with the energy metabolism of nematodes. Meanwhile, it inhibits the motility, feeding, and reproduction of nematodes, induces oxidative stress, reduces the protein content of nematodes, and impairs their antioxidant capacity. SDH-IN-24 can be used in the research related to anti-nematode fields .

HY-121149B

(E/Z)-Droloxifene (E/Z)-3-Hydroxytamoxifen	Estrogen Receptor/ERR Apoptosis	Cancer
(E/Z)-Droloxifene is a mixture of (E)-droloxifene (a selective estrogen receptor modulator) and (Z)-droloxifene. (E)-Droloxifene binds to the estrogen receptor (ER) with an IC₅₀ value of 24 nM in rabbit uterine homogenates. (E)-Droloxifene increases uterine weight in immature rats, and reduces estradiol-induced increases in uterine weight in juvenile rats. (E)-Droloxifene also inhibits 17β-estradiol-stimulated growth of MCF-7, ZR-75-1, and T47D human breast cancer cells. (Z)-Droloxifene binds weakly to ER and has no estrogenic or antiestrogenic activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0176

Dihydroartemisinin 40+ Cited Publications Dihydroqinghaosu; β-Dihydroartemisinin; Artenimol	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Source Classification	Parasite NF-κB Autophagy Reactive Oxygen Species (ROS) Drug Metabolite
Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection .

HY-N9599

Roridin A	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Fungal Endogenous Metabolite Parasite Insecticide
Roridin A acts as an inhibitor of pollen development in Arabidopsis thaliana and nematicide. Roridin A is isolated from the fungus Cylindrocarpon sp. Roridin A delays the flowering time of Arabidopsis thaliana, inhibits pollen development and stem elongation, and blocks plant growth. Roridin A induces larval death of the southern root-knot nematode (Meloidogyne incognita) .

HY-N7240

*(Rac)-Juvenile* hormone III**	Structural Classification Natural Products Animals Source Classification	Others
(Rac)-Juvenile hormone III is a *cecropia juvenile* hormone** and juvenile hormone agonist. (Rac)-Juvenile hormone III induces test insects to retain larval characteristics after the final molt to the adult stage. (Rac)-Juvenile hormone III exhibits juvenile hormone activity in Tenebrio molitor pupae and last-instar nymphs of Oncopeltus fasciatus. (Rac)-Juvenile hormone III possesses morphogenetic activity in insect assays .

HY-N3340

Macrocarpal I	Terpenoids Sesquiterpenes Phenols Polyphenols Myrtaceae Plants Eucalyptus globulus Labill. Source Classification	Fungal
Macrocarpal I is a phloroglucinol coupled sesquiterpenoid with antifungal activity. Macrocarpal I against C. glabrata with an IC₅₀ value of 0.75 μg/mL. Macrocarpal I can be isolated from the juvenile leaves of E. maideni .

HY-123897

Chamaejasmenin C	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones	Parasite
Chamaejasmenin C, a biflavanone, shows nematicidal activity against second-stage juveniles (J2s) of B. xylophilus and B. mucronatus .

HY-122530

Juvocimene I	Natural Products Labiatae Plants Helenium arizonicum S.F.Blake Source Classification	Insecticide
Juvocimene I is a potent juvenile hormone mimic. Juvocimene I can be isolated from the essential oil of sweet basil,Ocimum basilicum L .

HY-N6703A

(R)-ar-Turmerone (-)-ar-Turmerone	Structural Classification Natural Products Plants Curcuma longa Source Classification Zingiberaceae	Drug Derivative
(R)-ar-Turmerone is a sesquiterpene ketone that can be found in the sesquiterpene ketone fraction of Curcuma longa L. (R)-ar-Turmerone converts to ar-(+)-juvabione with juvenile hormone activity .

HY-135286B

(±)-rel-Neomenthol	Structural Classification Iridoids Terpenoids Labiatae Plants Mentha sachalinensis (Briq.) Kudô Source Classification	Drug Isomer
(±)-rel-Neomenthol is an alcohol component and isomer of (+)-Neomenthol (HY-135286A). (±)-rel-Neomenthol is derived from the essential oils of Mentha arvensis var. piperascens and the Mentha arvensis × Mentha crispa F1 hybrid .

HY-N10706

3-Keto sphinganine (d18:0)	Structural Classification Natural Products Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
3-Keto sphinganine (d18:0) serves as the substrate for 3-keto-dihydrosphingosine reductase in the de novo sphingolipid synthesis pathway, and is a key intermediate in the de novo synthesis of sphingoid long-chain bases. 3-Keto sphinganine (d18:0) can be used in studies related to thrombocytopenia, anemia .

Cat. No.	Product Name	Chemical Structure

HY-N7240S

(Rac)-Juvenile Hormone III-d3

Juvenile Hormone III-d₃ is the deuterium labeled Juvenile Hormone III. (Rac)-Juvenile Hormone III is a cecropia juvenile hormone and juvenile hormone agonist. (Rac)-Juvenile Hormone III induces test insects to retain larval characteristics after the final molt to the adult stage. (Rac)-Juvenile Hormone III exhibits juvenile hormone activity in Tenebrio molitor pupae and last-instar nymphs of Oncopeltus fasciatus. (Rac)-Juvenile Hormone III possesses morphogenetic activity in insect assays .

HY-B1161S

Methoprene-d7
Methoprene-d₇ is the deuterium labeled Methoprene . Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist .

HY-B1095S1

Chlormadinone acetate-d6-1

Chlormadinone acetate-d₆-1 is deuterium labeled Chlormadinone acetate (HY-B1095). Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .

HY-B1095S2

Chlormadinone acetate-d3

Chlormadinone acetate-d₃ is the deuterium labeled Chlormadinone acetate (HY-B1095). Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .

HY-N0176S6

Dihydroartemisinin-d

Dihydroartemisinin-d (Dihydroqinghaosu-d) is the deuterium labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure