644-06-4
Chemical Structure
Precocene II
Synonym(s): Ageratochromene
- CAS No.: 644-06-4
- Formula:C13H16O3
- Molecular Weight:220.26
IUPAC Name: 6,7-dimethoxy-2,2-dimethyl-2H-chromene
InChIKey: PTIDGSWTMLSGAH-UHFFFAOYSA-N
SMILES: CC1(C)C=CC2=CC(OC)=C(OC)C=C2O1
Biological Activity: Precocene II (Ageratochromene) is a plant larva hormone antagonists that inhibits the biosynthesis of juvenile hormone. Precocene II inhibits corpora allata function and downregulates juvenile hormone levels, while exerting multiple effects including inducing precocious metamorphosis, forming macropterous morphs, inhibiting ovarian growth, producing cytotoxicity, disrupting insect development, and causing sterility and kidney damage. Precocene II blocks normal nymphal development, causes renal tubular damage and increases blood urea nitrogen levels, and also blocks juvenile hormone biosynthesis in vitro. Precocene II undergoes oxidative metabolism catalyzed by NADPH-dependent monooxygenase to generate a variety of metabolites. Precocene II can be applied in studies related to insect growth regulation and nephrotoxicity[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Precocene II | 99.98% | Precocene II (Ageratochromene) is a plant larva hormone antagonists that inhibits the biosynthesis of juvenile hormone. Precocene II inhibits corpora allata function and downregulates juvenile hormone levels, while exerting multiple effects including inducing precocious metamorphosis, forming macropterous morphs, inhibiting ovarian growth, producing cytotoxicity, disrupting insect development, and causing sterility and kidney damage. Precocene II blocks normal nymphal development, causes renal tubular damage and increases blood urea nitrogen levels, and also blocks juvenile hormone biosynthesis in vitro. Precocene II undergoes oxidative metabolism catalyzed by NADPH-dependent monooxygenase to generate a variety of metabolites. Precocene II can be applied in studies related to insect growth regulation and nephrotoxicity. | ||||||||||||||||||||
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Precocene II (Standard) | ≥98% | Precocene II (Standard) is the analytical standard of Precocene II (HY-122940). This product is intended for research and analytical applications. Precocene II (Ageratochromene) is a plant larva hormone antagonists that inhibits the biosynthesis of juvenile hormone. Precocene II inhibits corpora allata function and downregulates juvenile hormone levels, while exerting multiple effects including inducing precocious metamorphosis, forming macropterous morphs, inhibiting ovarian growth, producing cytotoxicity, disrupting insect development, and causing sterility and kidney damage. Precocene II blocks normal nymphal development, causes renal tubular damage and increases blood urea nitrogen levels, and also blocks juvenile hormone biosynthesis in vitro. Precocene II undergoes oxidative metabolism catalyzed by NADPH-dependent monooxygenase to generate a variety of metabolites. Precocene II can be applied in studies related to insect growth regulation and nephrotoxicity. | ||||||||||||||||||||
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- [1]. Ayoade O. Induction of macroptery, precocious metamorphosis, and retarded ovarian growth by topical application of precocene II, with evidence for its non-systemic allaticidal effects in the brown planthopper, Nilapavata lugens. J Insect Physiol. 1996 Jun;42(6):529-540.
- [2]. Soderlund DM, et al. Precocene II Metabolism in Insects: Synthesis of Potential Metabolites and Identification of Initial in Vitro Biotransformation Products. J Agric Food Chem. 1980 Jul 1;28(4):724-731.
- [3]. Schrankel KR, et al. Precocene II nephrotoxicity in the rat. Toxicol Lett. 1982;12(2-3):95-100. [Content Brief]
- [4]. Pener M, et al. Precocene II causes atrophy of corpora allata in Locusta migratoria. Nature. 1978;272:350-353.
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