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Results for "

lignan compound

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Akt (3) AMPK (1) Apoptosis (4) Autophagy (1) Bacterial (3) Caspase (1) Endogenous Metabolite (1) ERK (1) GSK-3 (4) HBV (1) HIV (1) HIV Protease (1) IKK (1) Interleukin Related (4) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) mTOR (2) Necroptosis (1) NO Synthase (4) p38 MAPK (1) Parasite (1) PARP (1) PERK (1) PI3K (2) Reference Standards (2) SOD (1) Tau Protein (2) TNF Receptor (3) Tyrosinase (1)
By Research Areas:	Cancer (7) Endocrinology (3) Infection (8) Inflammation/Immunology (11) Metabolic Disease (3) Neurological Disease (7)

By Targets:

Acyltransferase (1)

Akt (3)

AMPK (1)

Apoptosis (4)

Autophagy (1)

Bacterial (3)

Caspase (1)

Endogenous Metabolite (1)

ERK (1)

GSK-3 (4)

HBV (1)

HIV (1)

HIV Protease (1)

IKK (1)

Interleukin Related (4)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (2)

mTOR (2)

Necroptosis (1)

NO Synthase (4)

p38 MAPK (1)

Parasite (1)

PARP (1)

PERK (1)

PI3K (2)

Reference Standards (2)

SOD (1)

Tau Protein (2)

TNF Receptor (3)

Tyrosinase (1)

By Research Areas:

Cancer (7)

Endocrinology (3)

Infection (8)

Inflammation/Immunology (11)

Metabolic Disease (3)

Neurological Disease (7)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6866

Gomisin N	Apoptosis AMPK Akt PERK Keap1-Nrf2 Caspase PARP GSK-3 NO Synthase Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Gomisin N is an orally active lignan compound. Gomisin N can be isolated from Schisandra chinensis. Gomisin N induces Apoptosis in a variety of cells. Gomisin N activates AMPK, Akt, MAPK/ERK, Nrf2, caspase-3 and PARP-1. Gomisin N inhibits GSK3β, nitric oxide (NO), and proinflammatory cytokines (IL-1β, IL-6, TNF-α). Gomisin N has anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis activities. Gomisin N has anti-tumor activity against cervical cancer and liver cancer. Gomisin N improves Alzheimer's disease .

HY-N0695

Schisantherin B 1 Publications Verification Gomisin-B; Wuweizi ester-B; Schisantherin-B	PI3K Akt mTOR GSK-3 Tau Protein TNF Receptor Interleukin Related Apoptosis	Neurological Disease Inflammation/Immunology
Schisantherin B (Gomisin-B) is a lignan compound and one of the active components of Schisandra chinensis. Schisantherin B activates the PI3K/AKT signaling pathway, restores the activity of GSK3β, and reduces the hyperphosphorylation of tau protein in hippocampal and cerebral cortical tissues. Schisantherin B upregulates the level of GLT-1, decreases the expression of pro-inflammatory cytokines TNF-α/IL-1β/IL-6, upregulates the expression of IL-10, and inhibits cell apoptosis. Schisantherin B is applicable to the research of spinal cord injury, Alzheimer's disease and depression .

HY-N8172

(+)-Secoisolariciresinol	Others	Others
(+)-Secoisolariciresinol, a lignan compound, is a (+)-enantiomer of Secoisolariciresinol .

HY-N8225

Manassantin B (-)-Manassantin B	Others	Others
Manassantin B (compound 6) is a kind of lignan. Manassantin B can be isolated from the ethyl acetate extract of the roots of Saururus chinensis. Manassantin B has cytotoxicities against HT-29 with an IC₅₀ value of 12 μM .

HY-N2270

Chicanine 1 Publications Verification	p38 MAPK ERK IKK	Inflammation/Immunology
Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity .

HY-N16614

Ent-Calquiquelignan E	Acyltransferase	Metabolic Disease
Ent-Calquiquelignan E (Compound 8) is a flavonoid lignan compound. Ent-Calquiquelignan E can selectively inhibit diacylglycerol acyltransferase 1 (DGAT1) with an IC₅₀ of 71.5 μM. Ent-Calquiquelignan E can be used for the research of metabolic diseas .

HY-N9233

Schisandrin C epoxide	Others	Others
Schisandrin C epoxide (compound 1) is a natural lignan found in Clerodendron inerme seeds .

HY-N5023

Veraguensin	Others	Metabolic Disease
Veraguensin is a lignan compound derived from Magnolia sp.. Veraguensin can inhibit bone resorption

HY-119439

Lignan J1	Others	Others
Lignan J1 is a lignan compound found in Justicia procumbens .

HY-N1216

Ssioriside	Others	Others
Ssioriside (compound 9) is a lignan xyloside, which can be isolated from the barks of Prunus ssiori and Prunus padus .

HY-N8159

Gomisin U	Others	Others
Gomisin U is a lignan compound .

HY-N7331

Ciwujiatone	Others	Cancer
Ciwujiatone is a natural lignan compound .

HY-N2914

(±)-Balanophonin	Others	Others
(±)-Balanophonin (compound 12) is a lignan first isolated from Otochilus fuscus .

HY-N11944

Schiarisanrin E	Others	Others
Schiarisanrin E (compound 5) is a lignan that can be isolated from Schisandra chinensis .

HY-N11921

Kadsurin A analogue-1	Others	Others
Kadsurin A analogue-1 (Compound 8) is a lignan can be extracted from Piper argyrophylum .

HY-N3892

Fargesone B	Others	Others
Fargesone B is a kind of lignan compound. Fargesone B can be isolated from Magnolia sprengeri .

HY-N11990

Nortrachelogenin 4'-O-β-gentiobioside	Others	Others
Nortrachelogenin 4'-O-β-gentiobioside (compound 20) is a lignan isolated from the aerial parts of Trachelospermius .

HY-N8172R

(+)-Secoisolariciresinol (Standard)	Reference Standards Others	Others
(+)-Secoisolariciresinol (Standard) is the analytical standard of (+)-Secoisolariciresinol. This product is intended for research and analytical applications. (+)-Secoisolariciresinol, a lignan compound, is a (+)-enantiomer of Secoisolariciresinol .

HY-N3745

(-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol	Others	Others
(-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol (compound 10) is a lignan isolated from Hedyotis uncinella .

HY-N12376

Renchangianin B	Others	Others
Renchangianin B (compound 2) is dibenzo cyclooctene-type *lignan. Renchangianin B can be isolated from the stems of Kadsura renchangiana* .

HY-N8021

Epipinoresinol-4-O-β-glucoside (+)-Epipinoresinol-4′′-β-D-glucoside	Others	Others
Epipinoresinol-4-O-β-glucoside (Compound 3) is a lignan glucoside that can be isolated from Forsythia suspensa .

HY-N7534

(+)-Epipinoresinol	Others	Others
(+)-Epipinoresinol is a lignan compound. CYP81Q3 specifically catalyzes methylenedioxy bridge (MDB) formation in (+)-Epipinoresinol to produce (+)-Pluviatilol .

HY-N11943

Kadsulignan H	NO Synthase	Others
Kadsulignan H (compound 13) is a lignan with inhibitory activity on NO production. Kadsulignan H inhibits NO production in BV-2 cells with an IC₅₀ of 14.1 μM .

HY-N11939

Kadsuralignan A	HIV	Infection
Kadsuralignan A (compound 1) is a dibenzocyclooctadiene lignan isolated from the leaves and stems of Schisandra lancifolia. Kadsuralignan A has anti-HIV activity with EC₅₀=2.23 μg/mL .

HY-N2140

Herpetone	Others	Infection
Herpetone, the ethylacetate extract, is a lignan compound. Herpetone can be isolated from the seeds of Herpetospermum caudigerum. Herpetone significantly improved the cell viability, and has a protective effect on hepatocytes in vitro .

HY-N11940

Acetyl-binankadsurin A	HIV Protease	Infection
Acetyl-binankadsurin A (compound 5) is a lignan isolated from Kadsura longipedunculata. Acetyl-binankadsurin A has low inhibitory activity against HIV-1 protease, with IC₅₀ >100 μg/mL .

HY-N12022

7(18)-Dehydroschisandro A	Others	Neurological Disease
7(18)-Dehydroschisandro A (Compound 2) is a lignan can be isolated from Schizandra chinensis Baill. 7(18)-Dehydroschisandro A has inhibitory effects on stress gastric ulcer .

HY-N12035

Picropodophyllin-4-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside	Others	Cancer
Picropodophyllin-4-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (compound 17) is a lignan isolated from the roots and rhizomes of Podophyllum sinensis .

HY-N10417

Apoptosis inducer 5	Apoptosis Autophagy	Cancer
Apoptosis inducer 5 (compound 1b) is a lignan enantiomer that can be found in Crataegus pinnatifida. Apoptosis inducer 5 exhibits cytotoxic effect via apoptosis and autophagy in Hep3B cells .

HY-N3761

Dimethylmatairesinol (-)-Maculatin; Methylarctigenin	Endogenous Metabolite	Others
Dimethylmatairesinol (compound 8) is a lignan compound isolated from the seed of Hernandia nymphaeifolia. Dimethylmatairesinol shows cytotoxicity against the KKU-M156 and HepG2 cell line with IC₅₀s of 5.4 μM (Emax 59%) and 5.2 μM (Emax 78%), respectively .

HY-N1841

Rocaglamide D 3'-Hydroxyrocaglamide	Others	Cancer
Rocaglamide D (3'-Hydroxyrocaglamide) (compound 1) is a lignan that can be found in Aglaia odorata. Rocaglamide D shows cytotoxicity with IC₅₀s of 0.32, 0.12, 0.25 µM for HeLa, SGC-7901, A549 cells, respectively .

HY-N12870

(7S,8R)-4,9,9'-Trihydroxy-3,3',5-trimethoxy-8,4'-oxyneolignan 4-O-β-D-glucopyranoside	Others	Endocrinology
(7S,8R)-4,9,9'-Trihydroxy-3,3',5-trimethoxy-8,4'-oxyneolignan 4-O-β-D-glucopyranoside (5) is a lignan compound that can be isolated from Smilax trinervula .

HY-N12102

Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside	HBV	Infection
Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside (compound 1) is a lignan with anti-HBC activity. Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside targets HBV surface antigen with IC₅₀s of 0.58 mM (HBsAg) and >2.4 mM (HBeAg). Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside can be isolated from star anise .

HY-N8618

Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol	Others	Others
Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol was identified as one of the phenolic compounds isolated from Canadian maple syrup (MS-BuOH). It exhibited antioxidant properties along with other phenolic compounds and coumarins isolated from the syrup. These compounds showed varying degrees of antioxidant activity, with phenolic derivatives and coumarins showing superior activity, more so than lignans and flavonoids. This study marks the first time that 16 of the 23 phenolic compounds, including Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol, have been identified in maple syrup .

HY-N0695R

Schisantherin B (Standard) Gomisin-B (Standard); Wuweizi ester-B (Standard); Schisantherin-B (Standard)	Reference Standards PI3K Akt mTOR GSK-3 Tau Protein TNF Receptor Interleukin Related Apoptosis	Neurological Disease Inflammation/Immunology
Schisantherin B (Gomisin-B) (Standard) is the analytical standard of Schisantherin B. This product is intended for research and analytical applications. Schisantherin B is a lignan compound and one of the active components of Schisandra chinensis. Schisantherin B activates the PI3K/AKT signaling pathway, restores the activity of GSK3β, and reduces the hyperphosphorylation of tau protein in hippocampal and cerebral cortical tissues. Schisantherin B upregulates the level of GLT-1, decreases the expression of pro-inflammatory cytokines TNF-α/IL-1β/IL-6, upregulates the expression of IL-10, and inhibits cell apoptosis. Schisantherin B is applicable to the research of spinal cord injury, Alzheimer's disease and depression.

HY-N19615

Isoeucommin A	Keap1-Nrf2 GSK-3 TNF Receptor Interleukin Related SOD	Inflammation/Immunology
Isoeucommin A is a lignan compound. Isoeucommin A activates the Nrf2/HO-1 pathway and induces phosphorylation of GSK-3β. Isoeucommin A reduces the levels of pro-inflammatory cytokines TNF-α, IL-1β and IL-6, decreases the oxidative stress marker MDA, increases the antioxidants SOD and GSH, and alleviates oxidative stress in mesangial cells. Isoeucommin A alleviates renal tissue injury, improves impaired renal function and enhances the viability of renal tubular epithelial cells in diabetic nephropathy models. Isoeucommin A can be used in the research of diabetic nephropathy .

HY-N17720

Arisanschinin M	Others	Others
Arisanschinin M (Compound 1) is a natural lignan. Arisanschinin M can be used in research on the synthesis of other compounds .

HY-N13808

4'-O-Methyllariciresinol	Others	Others
4'-O-Methyllariciresinol is a lignan compound isolated from neem (Aphanamixis grandifolia) .

HY-N8172S

(+)-Secoisolariciresinol-d6	Isotope-Labeled Compounds	Others
(+)-Secoisolariciresinol-d₆ is the deuterium labeled (+)-Secoisolariciresinol. (+)-Secoisolariciresinol, a lignan compound, is a (+)-enantiomer of Secoisolariciresinol .

HY-N11917

Schisantherin S	Others	Others
Schisantherin S is a dibenzocyclooctene-type lignan isolated from the stems of Schisandra chinensis (Kadsura) .

HY-N17417

Vladinol D	Others	Others
Vladinol D is a lignan compound. Vladinol D can be isolated from the branches of Keteleeria evelyniana and the leaves of Styrax annamensis .

HY-N18757

Tinospora cordifolia extract	Bacterial	Infection Inflammation/Immunology
Tinospora Cordifolia Extract is rich in bioactive compounds-such as alkaloids, glycosides, polysaccharides, and lignans—and possesses immunomodulatory, anti-inflammatory, antioxidant, and antimicrobial activities.

HY-N17765

rel-(7R,8'R,8S)-Forsythialan C	Others	Others
rel-(7R,8'R,8S)-Forsythialan C (compound 9) is a lignan compound that can be isolated from Forsythia suspensa.

HY-N18770

Bambusa arundinacea extract	Bacterial	Infection Inflammation/Immunology
Bambusa arundinacea extract is rich in various bioactive compounds, including flavonoids, phenolic acids, and lignans. Bambusa arundinacea extract possesses antioxidant, anti-inflammatory, and antibacterial properties.

HY-N12021

7(8)-Dehydroschisandrol A	Others	Neurological Disease
7(8)-Dehydroschisandrol A (Compound 4a) is a lignan can be isolated from Schizandra chinensis Baill. 7(8)-Dehydroschisandrol A has a weak inhibitory effect on stress-induced gastric ulcer .

HY-N16630

Dehydrodiconiferyl alcohol 4,γ′-di-O-β-D-glucopyranoside Dehydrodiconiferyl alcohol 4,9’-di-O-B-D-glucopyranoside	Others	Others
Dehydrodiconiferyl alcohol 4,γ′-di-O-β-D-glucopyranoside (Compound 4) is a lignan glycoside. Dehydrodiconiferyl alcohol 4,γ′-di-O-β-D-glucopyranoside can be isolated from the root bark of Morus alba L .

HY-N7999

Schisandrastemoside A	Others	Neurological Disease
Schisandrastemoside A (Compound 3) is a lignan found in the rattan stems of Schisandra chinensis. Schisandrastemoside A shows neuroprotective efect and protects cells against Amyloid-beta 1-42 (HY-P1363A)-induced neurotoxicity. Schisandrastemoside A can be used for the research of Alzheimer's disease .

HY-N3864A

(E/Z)-erythro-Guaiacylglycerol β-coniferyl ether	Others	Inflammation/Immunology
(E/Z)-erythro-Guaiacylglycerol β-coniferyl ether is a lignan compound found in Canadian maple syrup. (E/Z)-erythro-Guaiacylglycerol β-coniferyl ether exerts antioxidant acyivity and can scavenge DPPH radica. (E/Z)-erythro-Guaiacylglycerol β-coniferyl ether can be used for the research of inflammation .

HY-N17763

Styraxlignolide G	Others	Inflammation/Immunology
Styraxlignolide G is a furanofuran-type lignan compound that can be isolated from the stem bark of Styrax japonica. Styraxlignolide G exhibits very weak DPPH free radical scavenging activity, while its hydrolyzed aglycone molecule possesses antioxidant activity (IC₅₀=186.7 μM) and is involved in antioxidant-related regulation in the body. Styraxlignolide G can be used in the study of inflammatory diseases.

HY-N13754

Leptostachyol acetate	Parasite	Infection
Leptostachyol acetate is a lignan compound that can be isolated from the roots of Phryma leptostachya var. asiatica. Leptostachyol acetate exhibits larvicidal activity against mosquito larvae, with LC₅₀ values of 0.41, 2.1, and 2.3 ppm against third instar larvae of Culex pipiens pallens, Aedes aegypti, and Ocheratatos togoi, respectively. Leptostachyol acetate can be used for research on mosquito larval control .

Cat. No.	Product Name	Category	Target	Chemical Structure