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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
mTOR1
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "mTOR1" in MCE Product Catalog:
119
119 Publications Verification
Synonyms: RAD001; SDZ-RAD
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective, orally active, blood-brain barrier-permeable mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities [1] .
56
56 Cited Publications
Synonyms: INK-128; MLN0128; TAK-228
Sapanisertib (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase.
2
Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR .
1
1
1
1 Cited Publications
Cat. No.: HY-N2541
CAS No.: 122168-40-5
Category:
Triterpenes Terpenoids Asclepiadaceae Metabolic Disease Plants Disease Research Fields Gymnema sylvestre (Retz.) Schult.
Target:
1
1 Cited Publications
Synonyms: Telobufotoxin; Telocinobufogenin
Category:
Synonyms: RAD001-d4; SDZ-RAD-d4
Cat. No.: HY-10218R
CAS No.: 159351-69-6
Synonyms: RAD001 (Standard); SDZ-RAD (Standard)
Everolimus (Standard) is the analytical standard of Everolimus. This product is intended for research and analytical applications. Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities [1] .
Cat. No.: HY-23167
CAS No.: 1835759-85-7
Target:
Research Areas:
Acid-PEG4-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the inhibition of mTOR .
Target:
Research Areas:
Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR .
Cat. No.: HY-W073128
CAS No.: 376-06-7
Synonyms: PFTeDA
Research Areas:
Perfluorotetradecanoic acid (PFTeDA) is an orally active perfluoroalkyl substance. Perfluorotetradecanoic acid directly binds to the ligand-binding domain of purified hPPARγ, with a Kd value of 157.8 μM. Perfluorotetradecanoic acid significantly reduces the activity of the SIRT1/PGC1α and AMPK signaling pathways while stimulating the activity of the AKT1/mTOR signaling pathway. Perfluorotetradecanoic acid significantly upregulates the expression of corticosterone biosynthesis genes. Perfluorotetradecanoic acid increases ROS levels and promotes Apoptosis. Perfluorotetradecanoic acid impairs Leydig cell function and male reproductive endocrine function in adult male rats [1] .
TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR .
Cat. No.: HY-10218S1
CAS No.: 1661009-29-5
Synonyms: RAD001-13C2,d4; SDZ-RAD-13C2,d4
Cat. No.: HY-13328R
CAS No.: 1224844-38-5
Synonyms: INK-128 (Standard); MLN0128 (Standard); TAK-228 (Standard)
Target:
Research Areas:
Sapanisertib (Standard) is the analytical standard of Sapanisertib. This product is intended for research and analytical applications. Sapanisertib (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase.
Category:
Alkaloids Buxaceae Other Alkaloids Plants Buxus microphylla S.et Z.var. Sinica Rehd.et Wils.
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
