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nociceptive behavior

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) c-Myc (1) Calcium Channel (1) Epoxide Hydrolase (1) ERK (1) HDAC (1) Interleukin Related (2) Isotope-Labeled Compounds (2) NF-κB (1) NOD-like Receptor (NLR) (1) Orexin Receptor (OX Receptor) (4) P2X Receptor (1) p38 MAPK (1) Potassium Channel (1) Reactive Oxygen Species (ROS) (1) Sodium Channel (3) TNF Receptor (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (4) Neurological Disease (13)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-106224

Orexin A (human, rat, mouse) 10+ Cited Publications Hypocretin-1 (human, rat, mouse)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

HY-142240

Crisugabalin HSK16149	Calcium Channel	Neurological Disease
Crisugabalin is an orally active, selective ligand for the α2δ subunit of voltage-gated calcium channels, with a target IC₅₀ of 3.96 nM in rats. Crisugabalin inhibits the binding of [ ³H]gabapentin to the α2δ subunit, reduces calcium influx, decreases neuronal excitability, and impairs nociceptive transmission. Crisugabalin alleviates mechanical allodynia, neuropathic pain and inflammatory pain in rats, and reduces phase II pain behaviors. Crisugabalin can be used in research related to chronic pain, neuropathic pain, diabetic neuropathy, fibromyalgia, inflammatory pain, diabetic peripheral neuropathy and postherpetic neuralgia.

HY-N5025

Bullatine A	P2X Receptor Apoptosis ERK p38 MAPK c-Myc NF-κB Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression .

HY-119684

Maresin 2	NOD-like Receptor (NLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Maresin 2 is an anti-inflammatory and pro-resolving mediator. Maresin 2 drives intestinal epithelial cell migration by activating the focal cell-matrix adhesion signaling pathway in primary human intestinal epithelial cells, thereby promoting mucosal wound repair. Maresin 2 alleviates nociceptive and anxiety-like behaviors in rats with type 1 diabetes by inhibiting IL-1β in the spinal cord and prefrontal cortex. Maresin 2 attenuates allergic airway inflammation in mice by inhibiting the activation of the NLRP3 inflammasome, Th2-type immune responses, and oxidative stress. Maresin 2 inhibits inflammatory and neuropathic trigeminal neuralgia and reduces neuronal activation in the trigeminal ganglion. Maresin 2 promotes inflammation resolution and mucosal repair after DSS-induced colitis or biopsy-induced colonic mucosal injury .

HY-106224A

Orexin A (human, rat, mouse) TFA 10+ Cited Publications Hypocretin-1 (human, rat, mouse) TFA	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

HY-W021450A

DL-Fluorocitric acid barium	Biochemical Assay Reagents	Neurological Disease
DL-Fluorocitric acid barium is a glial cell metabolic inhibitor. DL-Fluorocitric acid barium inhibits mechanical hyperalgesia induced by subcutaneous injection of complete Freund's adjuvant in rats. DL-Fluorocitric acid barium inhibits nociceptive behaviors induced by Histamine (HY-B1204) in mice and blocks the phosphorylation of the NMDA receptor NR1 subunit in the lumbar spinal cord of mice. DL-Fluorocitric acid (barium) can be used in the research of mechanical hyperalgesia and nociceptive pain .

HY-159171

sEH/HDAC6-IN-2	Epoxide Hydrolase HDAC	Neurological Disease Inflammation/Immunology
sEH/HDAC6-IN-2 is a potent dual soluble epoxide hydrolase (sEH) and HDAC6 inhibitor with IC₅₀s of 0.9 nM, 46.8 nM, and 8 nM for human sEH, mouse sEH, and HDAC6, respectively. sEH/HDAC6-IN-2 can be used for the study of inflammatory pain .

HY-118048

NAV 26	Sodium Channel	Neurological Disease
NAV 26 (Compound 26) is a selective Na_V1.7 inhibitor with an IC₅₀ of 0.37 μM. NAV 26 is applicable for pain-related research .

HY-106224AS1

Orexin A-13C18,15N3 (human, rat, mouse) TFA Hypocretin-1-13C18,15N3 (human, rat, mouse) TFA	Isotope-Labeled Compounds Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse) ((Hypocretin-1- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse)) TFA is the ¹³C- and ¹⁵N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

HY-108425A

AMG8380	Sodium Channel	Neurological Disease
AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC₅₀s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC₅₀ of 2560 nM .

HY-183566

MK-5661	Sodium Channel	Neurological Disease
MK-5661 is an orally potent Na_V1.8 voltage-gated sodium channel inhibitor with an EC₅₀ of 4.3 nM. MK-5661 selectively inhibits peripheral nociceptive signaling mediators. MK-5661 reduces capsaicin-induced spontaneous nociceptive behaviors in humanized rats and attenuates capsaicin-induced skin flushing responses in rhesus monkeys. MK-5661 is applicable for pain-related research .

HY-N17853

Siaresinolic acid	Potassium Channel TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Siaresinolic acid is a compound found in the leaves of Sabicea grisea. Siaresinolic acid shows antinociceptive and anti-inflammatory activity. Siaresinolic acid reduces nociceptive behavior by ATP-dependent potassium channel, inhibits leukocyte influx, plasma leakage, and proinflammatory mediator (TNF-α, IL-1β) production. Siaresinolic acid does not induce cytotoxicity in murine macrophages, alter locomotor activity at high doses. Siaresinolic acid can be used for the research of pleurisy and pain .

HY-106224AS

Orexin A-13C6,15N (human, rat, mouse) TFA Hypocretin-1-13C6,15N (human, rat, mouse) TFA	Isotope-Labeled Compounds Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A- ¹³C₆, ¹⁵N (human, rat, mouse) (Hypocretin-1- ¹³C₆, ¹⁵N (human, rat, mouse)) TFA is the ¹³C- and ¹⁵N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

Cat. No.	Product Name	Target	Research Area

HY-106224

Orexin A (human, rat, mouse) 10+ Cited Publications Hypocretin-1 (human, rat, mouse)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

HY-106224A

Orexin A (human, rat, mouse) TFA 10+ Cited Publications Hypocretin-1 (human, rat, mouse) TFA	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

HY-106224AS1

Orexin A-13C18,15N3 (human, rat, mouse) TFA Hypocretin-1-13C18,15N3 (human, rat, mouse) TFA	Isotope-Labeled Compounds Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse) ((Hypocretin-1- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse)) TFA is the ¹³C- and ¹⁵N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

HY-106224AS

Orexin A-13C6,15N (human, rat, mouse) TFA Hypocretin-1-13C6,15N (human, rat, mouse) TFA	Isotope-Labeled Compounds Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A- ¹³C₆, ¹⁵N (human, rat, mouse) (Hypocretin-1- ¹³C₆, ¹⁵N (human, rat, mouse)) TFA is the ¹³C- and ¹⁵N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5025

Bullatine A	Alkaloids Piperidine Alkaloids Classification of Application Fields Ranunculaceae Aconitum carmichaeli Debx. Plants Inflammation/Immunology Disease Research Fields Source Classification	P2X Receptor Apoptosis ERK p38 MAPK c-Myc NF-κB Reactive Oxygen Species (ROS)
Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression .

HY-N17853

Siaresinolic acid	Structural Classification Terpenoids Rubiaceae Sabicea grisea Cham. & Schltdl. Plants Pentacyclic Triterpenoids Source Classification	Potassium Channel TNF Receptor Interleukin Related
Siaresinolic acid is a compound found in the leaves of Sabicea grisea. Siaresinolic acid shows antinociceptive and anti-inflammatory activity. Siaresinolic acid reduces nociceptive behavior by ATP-dependent potassium channel, inhibits leukocyte influx, plasma leakage, and proinflammatory mediator (TNF-α, IL-1β) production. Siaresinolic acid does not induce cytotoxicity in murine macrophages, alter locomotor activity at high doses. Siaresinolic acid can be used for the research of pleurisy and pain .

Cat. No.	Product Name	Chemical Structure

HY-106224AS1

Orexin A-13C18,15N3 (human, rat, mouse) TFA
Orexin A- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse) ((Hypocretin-1- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse)) TFA is the ¹³C- and ¹⁵N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

Orexin A-13C18,15N3 (human, rat, mouse) TFA

Orexin A- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse) ((Hypocretin-1- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse)) TFA is the ¹³C- and ¹⁵N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

HY-106224AS

Orexin A-13C6,15N (human, rat, mouse) TFA
Orexin A- ¹³C₆, ¹⁵N (human, rat, mouse) (Hypocretin-1- ¹³C₆, ¹⁵N (human, rat, mouse)) TFA is the ¹³C- and ¹⁵N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

Orexin A-13C6,15N (human, rat, mouse) TFA

Orexin A- ¹³C₆, ¹⁵N (human, rat, mouse) (Hypocretin-1- ¹³C₆, ¹⁵N (human, rat, mouse)) TFA is the ¹³C- and ¹⁵N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

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nociceptive behavior

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