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opposite

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By Targets:	Aminotransferases (Transaminases) (2) Antibiotic (1) Bacterial (2) Biochemical Assay Reagents (3) CXCR (2) Endogenous Metabolite (4) Estrogen Receptor/ERR (1) Isotope-Labeled Compounds (1) Liposome (2) LPL Receptor (1) Monoamine Oxidase (2) Opioid Receptor (1) Phosphodiesterase (PDE) (1) PKC (1) PPAR (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Endocrinology (2) Infection (3) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111793

NUCC-390 5+ Cited Publications	CXCR	Neurological Disease
NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046) . NUCC-390 promotes nerve recovery of function after neurodegeneration in vivo .

HY-W061674

trans-2-Pentenoic acid (E)-Pent-2-enoic acid	Biochemical Assay Reagents	Others
(2E)-Pent-2-enoic acid is an unsaturated carboxylic acid, it is also known as 2-pentenoic acid or crotonic acid, the "2E" designation indicates that the molecule has a trans double bond configuration, where the double bond The two carbon atoms on both sides are located on opposite sides, (2E)-Pent-2-enoic acid has a pungent odor, is miscible with water and most organic solvents, it is commonly used in organic synthesis as a variety of chemical reactions, including esterification, oxidation, and reduction, and in addition, its potential use as a flavoring agent in the food industry was investigated.

HY-111793A

NUCC-390 dihydrochloride 5+ Cited Publications	CXCR	Neurological Disease
NUCC-390 dihydrochloride is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 dihydrochloride induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046) . NUCC-390 dihydrochloride promotes nerve recovery of function after neurodegeneration in vivo .

HY-W127459

2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 95% D-DPPC, 95%	Liposome	Others
2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 95% (D-DPPC, 95%) is a chiral phospholipid that serves as a membrane-forming lipid component for bicelle assembly. 2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 95% can form bicelle assemblies with DHPC, which induce an induced circular dichroism (ICD) signal in the chiral probe DPH, with a polarity opposite to that induced by chiral L-DPPC/DHPC bicelles .

HY-116247

ST247	PPAR	Metabolic Disease Inflammation/Immunology
ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ .

HY-P2822

Phosphoglycerate kinase, yeast PGK	Endogenous Metabolite	Infection Endocrinology Cancer
Phosphoglycerate kinase, yeast (PGK), namely phosphoglycerate kinase, is a glycolytic enzyme commonly used in biochemical research. Phosphoglycerate kinase can catalyze the reversible transfer of phosphate groups from 1,3-bisphosphoglycerate (1,3-BPG) to ADP to generate 3-phosphoglycerate (3-PG) and ATP. At the same time, it can also participate in gluconeogenesis, catalyzing the opposite reaction to produce 1,3BPGA and ADP. Phosphoglycerate kinase is involved in energy metabolism, interaction with nucleic acid, tumor progression, cell death and virus replication and other related processes .

HY-19070

BRL-52656	Opioid Receptor	Cardiovascular Disease
BRL-52656 is a blood-brain barrier (BBB)-penetrable KOR receptor agonist that exhibits a biphasic effect. At low doses, BRL-52656 decreases blood pressure, whereas high doses have the opposite effect in spontaneously hypertensive rats. Additionally, BRL-52656 induces water diuresis by inhibiting the secretion of vasopressin (AVP) .

HY-148291

BrP-LPA sodium	LPL Receptor Phosphodiesterase (PDE)	Cancer
BrP-LPA sodium is a pan-opposite agent for lysophosphatidic acid (LPA). It has antagonistic activity against LPA₁ (IC₅₀ = 4520 nM), LPA₂ (IC₅₀ = 468 nM), LPA₃, and LPA₄. BrP-LPA sodium also has partial agonistic activity for LPA₅, with its EC₅₀ being 1282 nM. BrP-LPA sodium has ATX inhibitory activity. BrP-LPA sodium effectively inhibits the migration and invasion of breast cancer cells. BrP-LPA sodium achieves tumor regression and anti-angiogenesis in mice breast cancer xenograft model. BrP-LPA sodium can be used for the study of breast cancer .

HY-138690

Estrogen receptor modulator 6	Estrogen Receptor/ERR	Endocrinology
Estrogen receptor modulator 6 (compound 3a) is a selective estrogen receptor (ER) β agonist (K_i=0.44 nM). Estrogen receptor modulator 6 displays 19-fold selectivity for ERβ over ERα(K_i=8.4 nM) .

HY-N4277

Methyl protogracillin NSC-698793	Others	Cancer
Methyl protogracillin (NSC-698793), isolated from the roots of Dioscorea opposite Thunb, exhibits strong anti-cancer activity .

HY-N12119

ent-Prostaglandin F2α	Endogenous Metabolite	Others
ent-Prostaglandin F2α is the opposite enantiomer of PGF2α. ent-Prostaglandin F2α can be found in urine .

HY-135717

Norbiotinamine	Biochemical Assay Reagents	Cancer
Norbiotinamine is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction .

HY-135717A

Norbiotinamine hydrochloride	Biochemical Assay Reagents	Cancer
Norbiotinamine hydrochloride is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction .

HY-P1054

pep2-EVKI YNVYGIEEVKI	PKC	Neurological Disease
pep2-EVKI (YNVYGIEEVKI) is an inhibitor peptide that selectively blocks PICK1 interactions, caused the opposite effects on synaptic AMPAR function to PICK1 expression .

HY-W008440S

DL-Cycloserine-15N,d3	Isotope-Labeled Compounds Aminotransferases (Transaminases) Monoamine Oxidase	Neurological Disease Inflammation/Immunology
DL-Cycloserine- ¹⁵N,d₃ is the deuterium labeled DL-Cycloserine (HY-W008440). DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states .

HY-113884

(R)-Coriolic acid 13(R)-HODE	Endogenous Metabolite	Metabolic Disease
13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase. The presence of 13(R)-HODE in the supernatants and membranes of cultured bovine endothelial cells has been attributed to COX metabolism.1 13(R)-HODE is a weak (IC₅₀=2.7 μM) inhibitor of U-46619-induced platelet aggregation.

HY-W127459A

2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 99% D-DPPC, 99%	Liposome	Others
2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 99% (D-DPPC, 99%) is a chiral phospholipid that serves as a membrane-forming lipid component for bicelle assembly. 2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 99% can form bicelle assemblies with DHPC, which induce an induced circular dichroism (ICD) signal in the chiral probe DPH, with a polarity opposite to that induced by chiral L-DPPC/DHPC bicelles .

HY-129262

Deoxypheganomycin D	Antibiotic Bacterial	Infection
Deoxypheganomycin D is a specific antimycobacterial inhibitor with no cross-resistance to other antibiotics such as Paromomycin (HY-B0956), Capreomycin (HY-P3270), Viomycin (HY-A0155), Streptothricin (HY-129065), Kanamycin (HY-16566), and Streptomycin (HY-B1906). Deoxypheganomycin D (28 μM) partially inhibits the growth of Mycobacterium 607, with no significant inhibitory effects on DNA, RNA, or protein synthesis. Deoxypheganomycin D (7 μM) affects leucine influx, not thymidine, and has the opposite effect on efflux. The effects of Deoxypheganomycin D may be related to cell membrane and specific mycobacterial lipid components.

HY-W008440

DL-Cycloserine	Aminotransferases (Transaminases) Monoamine Oxidase	Neurological Disease Inflammation/Immunology
DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states .

HY-175761

Riboswit-modulator-1	Bacterial	Infection
Riboswit-modulator-1 (Compound A1), a covalent RNA ligand, is a bacterial Flavin mononucleotide (FMN) riboswitch modulator. Riboswit-modulator-1 modifies unpaired guanine residues (G11 and G62) proximal to the FMN-binding site through a proximity-driven mechanism, and interferes with its conformational transitions. Riboswit-modulator-1 acts as a negative antagonist by eliciting the opposite effect of the natural effector molecule .

HY-E70976

3-Phosphoglyceric Phosphokinase, Baker's yeast (S. cerevisiae)	Endogenous Metabolite	Metabolic Disease
3-Phosphoglyceric Phosphokinase, Baker's yeast (S. cerevisiae) (EC 2.7.2.3) is an enzyme that catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglyceRate (1,3-BPG) to ADP producing 3-phosphoglyceRate (3-PG) and ATP. 3-Phosphoglyceric Phosphokinase, Baker's yeast (S. cerevisiae) (EC 2.7.2.3) is a transferase. 3-Phosphoglyceric Phosphokinase is a major enzyme used in glycolysis, in the first ATP-geneRating step of the glycolytic pathway. In gluconeogenesis, the reaction catalyzed by 3-Phosphoglyceric Phosphokinase proceeds in the opposite direction, geneRating ADP and 1,3-BPG.

Cat. No.	Product Name	Type

HY-W061674

trans-2-Pentenoic acid (E)-Pent-2-enoic acid	Biochemical Assay Reagents
(2E)-Pent-2-enoic acid is an unsaturated carboxylic acid, it is also known as 2-pentenoic acid or crotonic acid, the "2E" designation indicates that the molecule has a trans double bond configuration, where the double bond The two carbon atoms on both sides are located on opposite sides, (2E)-Pent-2-enoic acid has a pungent odor, is miscible with water and most organic solvents, it is commonly used in organic synthesis as a variety of chemical reactions, including esterification, oxidation, and reduction, and in addition, its potential use as a flavoring agent in the food industry was investigated.

trans-2-Pentenoic acid

(E)-Pent-2-enoic acid

Biochemical Assay Reagents

(2E)-Pent-2-enoic acid is an unsaturated carboxylic acid, it is also known as 2-pentenoic acid or crotonic acid, the "2E" designation indicates that the molecule has a trans double bond configuration, where the double bond The two carbon atoms on both sides are located on opposite sides, (2E)-Pent-2-enoic acid has a pungent odor, is miscible with water and most organic solvents, it is commonly used in organic synthesis as a variety of chemical reactions, including esterification, oxidation, and reduction, and in addition, its potential use as a flavoring agent in the food industry was investigated.

HY-W127459

2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 95% D-DPPC, 95%	Biochemical Assay Reagents
2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 95% (D-DPPC, 95%) is a chiral phospholipid that serves as a membrane-forming lipid component for bicelle assembly. 2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 95% can form bicelle assemblies with DHPC, which induce an induced circular dichroism (ICD) signal in the chiral probe DPH, with a polarity opposite to that induced by chiral L-DPPC/DHPC bicelles .

2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 95%

D-DPPC, 95%

Biochemical Assay Reagents

2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 95% (D-DPPC, 95%) is a chiral phospholipid that serves as a membrane-forming lipid component for bicelle assembly. 2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 95% can form bicelle assemblies with DHPC, which induce an induced circular dichroism (ICD) signal in the chiral probe DPH, with a polarity opposite to that induced by chiral L-DPPC/DHPC bicelles .

HY-W127459A

2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 99% D-DPPC, 99%	Biochemical Assay Reagents
2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 99% (D-DPPC, 99%) is a chiral phospholipid that serves as a membrane-forming lipid component for bicelle assembly. 2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 99% can form bicelle assemblies with DHPC, which induce an induced circular dichroism (ICD) signal in the chiral probe DPH, with a polarity opposite to that induced by chiral L-DPPC/DHPC bicelles .

2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 99%

D-DPPC, 99%

Biochemical Assay Reagents

2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 99% (D-DPPC, 99%) is a chiral phospholipid that serves as a membrane-forming lipid component for bicelle assembly. 2,3-Dipalmitoyl-sn-glycero-1-phosphocholine, 99% can form bicelle assemblies with DHPC, which induce an induced circular dichroism (ICD) signal in the chiral probe DPH, with a polarity opposite to that induced by chiral L-DPPC/DHPC bicelles .

Cat. No.	Product Name	Target	Research Area

HY-135158

Prolylvaline Val-Pro; H-Val-Pro-OH	Peptides	Others
Prolylvaline (Pro-Val) is a proline-valine dipeptide that can be used to bind fluorescein isothiocyanate (FITC). Prolylvaline has specific imprinting effects in Tetrahymena, inducing negative imprinting. Using protozoan organisms, proline dipeptides containing different partner amino acids can be distinguished from dipeptides with opposite amino acid positions .

HY-P1054

pep2-EVKI YNVYGIEEVKI	PKC	Neurological Disease
pep2-EVKI (YNVYGIEEVKI) is an inhibitor peptide that selectively blocks PICK1 interactions, caused the opposite effects on synaptic AMPAR function to PICK1 expression .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4277

Methyl protogracillin NSC-698793	Other Terpenoids other families Classification of Application Fields Terpenoids Plants Disease Research Fields Cancer Source Classification	Others
Methyl protogracillin (NSC-698793), isolated from the roots of Dioscorea opposite Thunb, exhibits strong anti-cancer activity .

HY-N12119

ent-Prostaglandin F2α	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
ent-Prostaglandin F2α is the opposite enantiomer of PGF2α. ent-Prostaglandin F2α can be found in urine .

Cat. No.	Product Name	Chemical Structure

HY-W008440S

DL-Cycloserine-15N,d3
DL-Cycloserine- ¹⁵N,d₃ is the deuterium labeled DL-Cycloserine (HY-W008440). DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85501

	SMYD1 Antibody (YA5193) BOP; CD8 beta opposite; CD8b opposite; Histone lysine N methyltransferase SMYD1; KMT3D; SET and MYND domain-containing protein 1; SMYD1; SMYD1_HUMAN; Zinc finger MYND domain containing 18; ZMYND18; ZMYND22; zinc finger, MYND domain containing 18.	WB	Rat
	SMYD1 Antibody (YA5193) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SMYD1.

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opposite

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Natural
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