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Norbiotinamine is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction.

For research use only. We do not sell to patients.

Norbiotinamine Chemical Structure

Norbiotinamine Chemical Structure

CAS No. : 173401-47-3

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5 mg USD 220 In-stock
10 mg USD 350 In-stock
25 mg USD 690 In-stock
50 mg USD 1100 In-stock
100 mg USD 1800 In-stock
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Based on 1 publication(s) in Google Scholar

Norbiotinamine Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Norbiotinamine is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction[1].

In Vitro

In order to couple biotin to amino acids, reaction has to be with an amino group. An example is biocytin (biotin lysine). However, Norbiotinamine could be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction. As an example, Norbiotinamine is coupled with the NHS ester of N-Boc-glutamic acid γ-benzyl ester. The resulting norbiotinylamide of γglutamic acid (VII), obtained after deprotection, is similar to biocytin, but it has a shorter aliphatic chain and an inverted amide bond[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Norbiotinamine Related Antibodies
Molecular Weight

215.32

Formula

C9H17N3OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N[C@](CS[C@H]2CCCCN)([H])[C@]2([H])N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 200 mg/mL (928.85 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6443 mL 23.2213 mL 46.4425 mL
5 mM 0.9288 mL 4.6442 mL 9.2885 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (464.43 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.6443 mL 23.2213 mL 46.4425 mL 116.1063 mL
5 mM 0.9289 mL 4.6443 mL 9.2885 mL 23.2213 mL
10 mM 0.4644 mL 2.3221 mL 4.6443 mL 11.6106 mL
15 mM 0.3096 mL 1.5481 mL 3.0962 mL 7.7404 mL
20 mM 0.2322 mL 1.1611 mL 2.3221 mL 5.8053 mL
25 mM 0.1858 mL 0.9289 mL 1.8577 mL 4.6443 mL
30 mM 0.1548 mL 0.7740 mL 1.5481 mL 3.8702 mL
40 mM 0.1161 mL 0.5805 mL 1.1611 mL 2.9027 mL
50 mM 0.0929 mL 0.4644 mL 0.9289 mL 2.3221 mL
60 mM 0.0774 mL 0.3870 mL 0.7740 mL 1.9351 mL
80 mM 0.0581 mL 0.2903 mL 0.5805 mL 1.4513 mL
100 mM 0.0464 mL 0.2322 mL 0.4644 mL 1.1611 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Norbiotinamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Norbiotinamine173401-47-3OthersInhibitorinhibitorinhibit

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