Synthesis of norbiotinamine and its derivatives

  • Bioconjug Chem. 1996 Mar-Apr;7(2):271-3. doi: 10.1021/bc950094f.
W Szalecki  1
Affiliations
  • 1. Molecular Probes, Inc., Eugene, Oregon 97402, USA.
PMID: 8983350 DOI: 10.1021/bc950094f
Abstract

Synthesis of norbiotinamine (II) and its reactive derivatives, isothiocyanates (III and IV), iodoacetamide (V), and maleimide (VI), are described. In addition, N-norbiotinyl-gamma-L-glutamylamide (VII) was prepared as a potential alternative to the fixable polar tracer biocytin (biotinoyllysine).

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