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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
p16
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "p16" in MCE Product Catalog:
6
6 Publications Verification
Referencia número: HY-B1165
No. CAS: 41354-29-4
Áreas de investigación:
Cyproheptadine hydrochloride sesquihydrate acts as a p38 MAP kinase activator, CHK2 activator, histamine H1 receptor inhibitor and serotonin receptor inhibitor. Cyproheptadine hydrochloride sesquihydrate mediates cell cycle arrest via G1 phase arrest, G1/S transition arrest, G0/G1 phase arrest, reduced expression of cyclins D1/D2/D3, upregulated expression of HBP1, p16, p21, p27, and decreased phosphorylation of retinoblastoma protein. Cyproheptadine hydrochloride sesquihydrate induces Apoptosis by increasing PARP and cleaved PARP, as well as activating the mitochondrial caspase pathway. Cyproheptadine hydrochloride sesquihydrate inhibits tumor growth with extremely low toxicity to normal cells. Cyproheptadine hydrochloride sesquihydrate can be used in research related to hepatocellular carcinoma, multiple myeloma and acute myeloid leukemia .
2
2 Cited Publications
Target:
Áreas de investigación:
MS37452 is a potent inhibitor of CBX7 chromodomain binding to H3K27me3, with a Kd of 27.7 μM. MS37452 can derepress transcription of polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells .
1
1 Cited Publications
Target:
Áreas de investigación:
RSC133 is a dual inhibitor of DNA methyltransferase 1 and histone deacetylase 1 inhibitor. RSC133 promotes cell proliferation, up-regulates H3K9 histone acetylation, down-regulates p53, p21, p16/INK4A, and ablates pro-senescence phenotypes .
1
1 Cited Publications
Referencia número: HY-N0857
No. CAS: 79233-15-1
1
1 Cited Publications
Referencia número: HY-P86438
Synonyms: Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; Cyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4A; p16;
1
1 Cited Publications
Referencia número: HY-P80615
Synonyms: CDK4 inhibitor p16 INK4 antibody;
CDK4I antibody;
CDKN2 antibody;
CDKN2A antibody;
Cell cycle negative regulator beta antibody;
CMM2 antibody;
Cyclin dependent kinase 4 inhibitor A antibody;
Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) antibody;
Cyclin Dependent Kinase Inhibitor 2A antibody;
Cyclin dependent kinase inhibitor 2A isoform 4 antibody;
Cyclin dependent kinase inhibitor 2A isoforms 1/2/3 antibody;
Cyclin dependent kinase inhibitor p16 antibody;
INK4 antibody;
INK4A antibody;
MLM antibody;
MTS1 antibody;
Multiple tumor suppressor 1 antibody;
p14 antibody;
p16 antibody;
p16INK4 antibody;
p16INK4a antibody;
p19 antibody;
p19Arf antibody;
Tp16 antibody;
1
Referencia número: HY-P1109
No. CAS: 189064-08-2
Referencia número: HY-171030
No. CAS: 2222067-12-9
Target:
Áreas de investigación:
Pro-GA is a γ-glutamyl cyclotransferase (GGCT) inhibitor. Pro-GA inhibits the enzymatic activity of GGCT, disrupts glutathione homeostasis, induces the production of mitochondrial ROS, and upregulates the expression of p21, p27 and p16 in cells. Pro-GA inhibits the growth of cancer cells, induces cell cycle arrest and cellular senescence. Pro-GA exerts anti-tumor effects in breast cancer xenograft mouse models. Pro-GA can be used in research related to bladder cancer and breast cancer .
Referencia número: HY-169265
No. CAS: 452350-43-5
Target:
Áreas de investigación:
BRD-K20733377 is an inhibitor for Bcl-2, and exhibits selective cytotoxicity against senescent cells, that inhibits the viability of Etoposide (HY-13629)-induced IMR-90 senescent cell with an IC50 of 10.7 μM. BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21 and KI67 in aged mouse model .
Referencia número: HY-P3602
No. CAS: 99027-06-2
Referencia número: HY-165997
No. CAS: 126901-45-9
Synonyms: PC-(p16:0/16:0)
Target:
Áreas de investigación:
1-1(Z)-Hexadecenyl-2-Palmitoyl-sn-glycero-3-PC is an ester product.
Referencia número: HY-N11604
No. CAS: 204983-72-2
Synonyms: C16(Plasm)-16:1-PC; PC(P-16:0/16:1); PlsC 16:0/16:1
Target:
Referencia número: HY-168895
No. CAS: 3125025-31-9
c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth .
Referencia número: HY-N0992
No. CAS: 25577-04-2
Referencia número: HY-165157
No. CAS: 84460-45-7
Synonyms: 16:0p/20:4-PC; PC(P-16:0/20:4); C16(plasm)-20:4-PC
Target:
Áreas de investigación:
1-1(Z)-Hexadecenyl-2-arachidonoyl-sn-glycero-3-PC is a biochemical reagent.
Referencia número: HY-RS16296
Target:
Áreas de investigación:
H3P10 Human Pre-designed siRNA Set A contains three designed siRNAs for H3P10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
