423748-02-1
423748-02-1
Chemical Structure
MS37452
- CAS No.: 423748-02-1
- Formula:C22H26N2O5
- Molecular Weight:398.45
IUPAC Name: 1-(4-(2,3-dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethan-1-one
InChIKey: LUMCNRKHZRYQOV-UHFFFAOYSA-N
SMILES: CC1=CC(OCC(N2CCN(CC2)C(C3=CC=CC(OC)=C3OC)=O)=O)=CC=C1
Biological Activity: MS37452 is a potent inhibitor of CBX7 chromodomain binding to H3K27me3, with a Kd of 27.7 μM. MS37452 can derepress transcription of polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MS37452 | 99.81% | MS37452 is a potent inhibitor of CBX7 chromodomain binding to H3K27me3, with a Kd of 27.7 μM. MS37452 can derepress transcription of polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.57
HY-149471hTYR/AbTYR-IN-1 -
Similarity Score 0.57
HY-117497Simetride -
Similarity Score 0.57
HY-122185Anticancer agent 211 -
Similarity Score 0.57
HY-106935ACGP 29030A -
Similarity Score 0.55
HY-160038GAC0003A4 -
Similarity Score 0.55
HY-B1124Fipexide -
Similarity Score 0.55
HY-28325AMC-04 -
Similarity Score 0.55
HY-B1124AFipexide hydrochloride -
Similarity Score 0.55
HY-130041Tropapride -
Explore the MedChemAI to find more analogs
