1418131-46-0
1418131-46-0
Chemical Structure
RSC133
- CAS No.: 1418131-46-0
- Formula:C18H15N3O2
- Molecular Weight:305.33
IUPAC Name: (E)-3-(3-(1H-indol-3-yl)acrylamido)benzamide
InChIKey: HYUDSQGICKAEGE-CMDGGOBGSA-N
SMILES: NC(C1=CC=CC(NC(/C=C/C2=CNC3=CC=CC=C23)=O)=C1)=O
Biological Activity: RSC133 is a dual inhibitor of DNA methyltransferase 1 and histone deacetylase 1 inhibitor. RSC133 promotes cell proliferation, up-regulates H3K9 histone acetylation, down-regulates p53, p21, p16/INK4A, and ablates pro-senescence phenotypes[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RSC133 | 98.45% | RSC133 is a dual inhibitor of DNA methyltransferase 1 and histone deacetylase 1 inhibitor. RSC133 promotes cell proliferation, up-regulates H3K9 histone acetylation, down-regulates p53, p21, p16/INK4A, and ablates pro-senescence phenotypes. | ||||||||||||||||||||
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References
- [1]. Lee J, et al. A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells. Angew Chem Int Ed Engl. 2012;51(50):12509-12513. [Content Brief]
- [2]. Kwon D, et al. The Effect of Fetal Bovine Serum (FBS) on Efficacy of Cellular Reprogramming for Induced Pluripotent Stem Cell (iPSC) Generation. Cell Transplant. 2016;25(6):1025-1042. [Content Brief]
