A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

  • Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12509-13. doi: 10.1002/anie.201206691.
Jungwoon Lee  1 ,  Yan Xia ,  Mi-Young Son ,  Guanghai Jin ,  Binna Seol ,  Min-Jeong Kim ,  Myung Jin Son ,  Misol Do ,  Minho Lee ,  Dongsup Kim ,  Kyeong Lee ,  Yee Sook Cho
Affiliations
  • 1. Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, S. Korea.
PMID: 23125037 DOI: 10.1002/anie.201206691
Abstract

Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA Methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).

Products