C3 Peptide P16
C3 Peptide P16, is a 16 amino acid synthetic peptide derived from human C3d, a fragment generated in trypsin-cleaved C3. C3 Peptide P16 enhances in vitro phosphorylation of pp105 and pp100, a cellular component presenting in the human B lymphoma cells.
For research use only. We do not sell to patients.
- CAS No.: 99027-06-2
- Formula: C86H131N25O27
- Molecular Weight:1947.12
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
C3 Peptide P16 (7.4 μM; 18 h) triggers in vitro and in vivo phosphorylations and in vitro proliferation of human B lymphocytes, depending on the stage of cell differentiation[1].
C3 Peptide P16 (7 nM; 60 min; 4 °C) induces in vivo tyrosine phosphorylation of pp105 and (15 μM; 6-8 d) enhances proliferation only of CR2-pos. but not of CR2-neg. cell lines in vitro[1].
C3 Peptide P16 (7.4 μM; 18 h) also induces in vivo tyrosine phosphorylation of pp100 and in vivo proliferation of only small dense resting B lymphocytes and not other B lymphocyte subpopulations nor T lymphocytes[1].
C3 Peptide P16 (0.3-10 μM; 3 min; 33 °C) dose-dependently regulates pp105 phosphorylation, as well as C3d fragment present in trypsin-cleaved C3[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 99027-06-2
-
Molecular Weight 1947.12
-
Formula C86H131N25O27
-
Sequence Shortening
KNRWEDPGKQLYNVEA
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sachdeva R, et al. DING proteins from phylogenetically different species share high degrees of sequence and structure homology and block transcription of HIV-1 LTR promoter. PLoS One. 2013 Aug 6;8(8):e69623. [Content Brief]
[2]. Frade R, et al. A 16 amino acid synthetic peptide derived from human C3d triggers proliferation and specific tyrosine phosphorylation of transformed CR2-positive human lymphocytes and of normal resting B lymphocytes. Biochem Biophys Res Commun. 1992 Oct 30;188(2):833-42. [Content Brief]
[3]. Lyamani F, et al. A 16 amino-acid synthetic peptide, derived from human C3d, carries regulatory activity on in vitro phosphorylation of a cellular component of the human B lymphoma cells, Raji. Biochem Biophys Res Commun. 1991 Mar 29;175(3):823-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
C3 Peptide P16 Related Classifications
HY-P3602 Related Classifications
Powered by Bioz