2222067-12-9
Chemical Structure
Pro-GA
- CAS No.: 2222067-12-9
- Formula:C12H19NO7
- Molecular Weight:289.28
InChIKey: GYBSTWDRGMHMOZ-QMMMGPOBSA-N
SMILES: O=C(OC)CCCC(N[C@@H](C)C(OCOC(C)=O)=O)=O
Biological Activity: Pro-GA is a γ-glutamyl cyclotransferase (GGCT) inhibitor. Pro-GA inhibits the enzymatic activity of GGCT, disrupts glutathione homeostasis, induces the production of mitochondrial ROS, and upregulates the expression of p21, p27 and p16 in cells. Pro-GA inhibits the growth of cancer cells, induces cell cycle arrest and cellular senescence. Pro-GA exerts anti-tumor effects in breast cancer xenograft mouse models. Pro-GA can be used in research related to bladder cancer and breast cancer[1][2].
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Pro-GA | 97.86% | Pro-GA is a γ-glutamyl cyclotransferase (GGCT) inhibitor. Pro-GA inhibits the enzymatic activity of GGCT, disrupts glutathione homeostasis, induces the production of mitochondrial ROS, and upregulates the expression of p21, p27 and p16 in cells. Pro-GA inhibits the growth of cancer cells, induces cell cycle arrest and cellular senescence. Pro-GA exerts anti-tumor effects in breast cancer xenograft mouse models. Pro-GA can be used in research related to bladder cancer and breast cancer. | ||||||||||||||||||||
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- [1]. Hanada E, et al. Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth. Anticancer Res. 2019;39(4):1893-1898. [Content Brief]
- [2]. Ii H, et al. The γ-Glutamylcyclotransferase Inhibitor Pro-GA Induces an Antiproliferative Effect Through the Generation of Mitochondrial Reactive Oxygen Species. Anticancer Res. 2022;42(9):4311-4317. [Content Brief]
Keywords
