Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
protein loading
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "protein loading" in MCE Product Catalog:
18
18 Publications Verification
Synonyms: Tetraphenylethene maleimide
3
1
Cat. No.: HY-P99647
CAS No.: 1257358-38-5
Synonyms: ALX-0171; VR-465
Cat. No.: HY-P99344
CAS No.: 2423943-37-5
Synonyms: Anti-Human SARS-CoV-2; LY-3819253; LY-CoV555
Cat. No.: HY-DY1024
CAS No.: 1245606-71-6
Solvent and concentration: DMSO: 10 mM
Cat. No.: HY-121663
CAS No.: 400863-77-6
Target:
Domaines de recherche:
ST-148 is a novel small molecule compound that has potent inhibitory effects against all four dengue virus serotypes. In the nonlethal AG129 mouse dengue virus infection model, ST-148 significantly reduced viremia and viral load in vital organs and tended to reduce plasma cytokine levels. Compound resistance was associated with the dengue virus capsid (C) gene, and the direct interaction of ST-148 with the C protein was presumed to be achieved through the protein's built-in fluorescence change in the presence of the compound. Therefore, ST-148 appears to interact with the dengue virus C protein and inhibit one or more unique steps of the viral replication cycle.
Cat. No.: HY-N6799
CAS No.: 36519-25-2
Cat. No.: HY-U00380
CAS No.: 102507-71-1
Target:
Domaines de recherche:
Tigemonam is an orally active monobactam antibiotic with a Ki of 0.86 μM against Enterobacter cloacae P99 β-lactamase and 50.8 μM against Escherichia coli TEM-1 β-lactamase. Tigemonam binds to penicillin-binding proteins 1a, 3, and 4, inhibits bacterial cell wall synthesis, and exhibits bactericidal activity against aerobic gram-negative bacteria including Enterobacteriaceae, Haemophilus influenzae, and Neisseria gonorrhoeae. Tigemonam resists hydrolysis by multiple β-lactamase enzymes, reduces bacterial load in systemic, pyelonephritic, lung, and thigh muscle infections in rodents, and shows minimal difference between minimum inhibitory and bactericidal concentrations. Tigemonam can be used for the research of gram-negative bacterial infections, acute pyelonephritis, lung infection, and thigh muscle infection .
Cat. No.: HY-P3402
Target:
Domaines de recherche:
Cat. No.: HY-P3402A
Target:
Domaines de recherche:
Cat. No.: HY-136219
CAS No.: 2098621-90-8
Target:
Domaines de recherche:
Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs). Protein kinase affinity probe 1 is a modified Purvalanol B (HY-18299) probe with 50% beads loading (Compound S3) .
Cat. No.: HY-N6799R
CAS No.: 36519-25-2
Category:
Cat. No.: HY-K0224
MCE Amino magnetic beads (200 nm，10 mg/mL) can easily and efficiently combine with a variety of biological ligand in high loads, such as proteins, peptides, oligonucleotides, drug molecules, etc. It can be used as a good basic material for subsequent processing, adsorption, chemical modification and other follow-up processing.
Cat. No.: HY-184586
SOS1-IN-28 is an orally active, blood-brain barrier permeable SOS1 inhibitor with an IC50 value of 0.11 μM. SOS1-IN-28 disrupts the SOS1: KRAS protein-protein interaction, with an IC50 of 0.29 μM for the KRAS-RAF interaction. SOS1-IN-28 blocks GTP loading of KRAS, inhibits RAS-MAPK pathway activity, and reduces cancer cell proliferation. SOS1-IN-28 can be used for the research of KRAS G12C-mutant lung cancer .
Cat. No.: HY-184669
CAS No.: 2740494-38-4
MERS-CoV-IN-4 is an orally active antiviral inhibitor targeting the MERS-CoV spike (S) protein, with an IC50 of 0.009 μM in Huh-7 cells, and Kd values of 7.72 μM for the full-length S protein and 5.09 μM for S-RBD. MERS-CoV-IN-4 inhibits viral entry, and suppresses MERS-CoV pseudoviruses and live viruses in vitro. MERS-CoV-IN-4 reduces pulmonary viral loads in hDPP4 transgenic mice. MERS-CoV-IN-4 can be used for research on Middle East respiratory syndrome coronavirus infection .
Cat. No.: HY-180785
CAS No.: 932311-85-8
Target:
Domaines de recherche:
G243-1720 is a potent, orally active, broad-spectrum anti-orthopoxvirus agent that functions by targeting the OPG57 (F13) protein and inducing its dimerization. G243-1720 effectively inhibits the replication of various poxviruses, but has no inhibitory effect on non-poxviruses. G243-1720 prevents the formation of extracellular membrane virus particles and the spread between cells. G243-1720 significantly reduces the viral load of monkeypox virus (MPXV) in the lungs of mice
Cat. No.: HY-183688
CAS No.: 3104354-58-4
Target:
Domaines de recherche:
MptpB-IN-3 is a selective inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with an IC50 of 0.19 μM. MptpB-IN-3 blocks MptpB-mediated inhibition of the macrophage MAPK pathway and restores the phosphorylation levels of Erk1/2 and p38. MptpB-IN-3 exhibits direct anti-tuberculosis activity against Mycobacterium tuberculosis and reduces the Mycobacterium tuberculosis load in mouse macrophages. MptpB-IN-3 can be used for tuberculosis research .
Cat. No.: HY-N10650
CAS No.: 26612-48-6
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
