2. Anti-infection
  3. RSV
  4. Gontivimab

Gontivimab  (Synonyms: ALX-0171; VR-465)

Cat. No.: HY-P99647

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Gontivimab (ALX-0171; VR-465) is a poent anti-RSV prefusion F protein nanobody with a KD value of 0.113 nM. Gontivimab shows antiviral activity. Gontivimab reduces the RSV load in the nose and lung.

For research use only. We do not sell to patients.

Gontivimab Chemical Structure

Gontivimab Chemical Structure

CAS No. : 1257358-38-5

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Gontivimab Related Antibodies

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Description

Gontivimab (ALX-0171; VR-465) is a poent anti-RSV prefusion F protein nanobody with a KD value of 0.113 nM. Gontivimab shows antiviral activity. Gontivimab reduces the RSV load in the nose and lung[1].

IC50 & Target

KD: 0.113 nM (RSV prefusion F protein)[1]
In Vitro

Gontivimab (0-100000 nM) shows antiviral activity with IC50s of 0.1, 0.4 nM for RSV-A, RSV-B 18537 strain, respectively[1].
Gontivimab binds to antigenic site II of F protein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gontivimab Related Antibodies
In Vivo

Gontivimab (1-68 mg/kg; intranasal administration or nebulization) reduces the RSV load in the nose and lungs in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (RSV Tracy)[1]
Dosage: 1-68 mg/kg
Administration: Intranasal administration or nebulization; once (day 2 or day 3) or twice (day 2 and day 3)
Result: Resulted in significant viral load reductions in the lungs ranging.
CAS No.
SMILES

[Gontivimab]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Gontivimab Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gontivimab1257358-38-5ALX-0171 VR-465ALX0171ALX 0171VR465VR 465VR-465RSVRespiratory syncytial virusantiviralRSV-ARSV-B 18537intranasal administrationnebulizationviral loadInhibitorinhibitorinhibit

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