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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
122 Results for "
receptor-associated
" in MedChemExpress (MCE) Product Catalog:
Products (122)
122 Results for "receptor-associated" in MCE Product Catalog:
11
11 Publications Verification
Synonyms: IRAK-1/4 Inhibitor I
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IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.2 μM and 0.3 μM, respectively.
11
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Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine has anxiolytic and cytostatic effects .
7
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Zimlovisertib (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. Zimlovisertib is used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas .
6
6 Cited Publications
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JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice . JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC50 of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 μM .
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6 Cited Publications
JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice .
2
2 Cited Publications
Cat. No.: HY-P76479A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LRPAP1; Low Density Lipoprotein-Related Protein-associated Protein 1 (Alpha-2-Macroglobulin receptor-associated Protein 1); Prev. A2MRAP; Low Density Lipoprotein receptor-Related Protein-associated Protein 1; Prev. RAP; 39 KDa receptor-associated Protein
2
2 Cited Publications
Cat. No.: HY-P76479
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LRPAP1; Low Density Lipoprotein-Related Protein-associated Protein 1 (Alpha-2-Macroglobulin receptor-associated Protein 1); Prev. A2MRAP; Low Density Lipoprotein receptor-Related Protein-associated Protein 1; Prev. RAP; 39 KDa receptor-associated Protein
1
1 Cited Publications
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IRAK4-IN-4 (Compound 15) is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, with an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM. IRAK4-IN-4 can be used for research of autoimmune diseases .
1
1 Cited Publications
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IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.
1
1 Cited Publications
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IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.
1
1 Cited Publications
Cat. No.: HY-P76478A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LRPAP1; Low Density Lipoprotein-Related Protein-associated Protein 1 (Alpha-2-Macroglobulin receptor-associated Protein 1); Prev. A2MRAP; Low Density Lipoprotein receptor-Related Protein-associated Protein 1; Prev. RAP; 39 KDa receptor-associated Protein
1
1 Cited Publications
Cat. No.: HY-P71082
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: S100A6; Protein S100-A6; Prev. CACY; S100 Calcium-Binding Protein A6 (Calcyclin); PRA; S100 Calcium-Binding Protein A6; Calcyclin; S100 Calcium-Binding Protein; CABP; Protein S100; 2A9; S10A6; Prolactin receptor-associated Protein; 5B10; Growth Factor-Ind
1
1 Cited Publications
AZ1495, a weak base, is a potent orally active interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor. AZ1495 has a favorable physicochemical and kinase selectivity for IRAK4 and IRAK1 with IC50 values of 0.005 μM and 0.023 μM, respectively. AZ1495 has IRAK4 inhibition with a Kd value of 0.0007 μM. AZ1495 can be used for the research of diffuse large B-cell lymphoma (DLBCL) .
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IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
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IRAK4-IN-7 is a selective, potent and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, extracted from patent WO2015104688 (example 1). IRAK4-IN-7 has the potential for cancer and inflammatory diseases treatment .
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PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4), with an IC50 of 0.3 nM .
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IRAK inhibitor 2 is an interleukin-1 receptor-associated kinase (IRAK) inhibitor. IRAK inhibitor 2 can be used for the research of inflammatory and immune diseases .
Cat. No.: HY-P5432
CAS No.: 2837877-90-2
Synonyms: IRAK-1 (360-380)
Cat. No.: HY-77048
CAS No.: 301675-24-1
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IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders .
Cat. No.: HY-173025
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Nurr1 agonist 12 (Compound 37) is the agonist for nuclear receptor-associated protein 1 (Nurr1) that activates the transcriptional activity of Nurr1 with an EC50 of 0.06 μM. Nurr1 agonist 12 activates the human response elements NBRE, NurRE, and DR5 with EC50 of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Nurr1 agonist 12 induces the expression of Nurr1-regulated neurotrophic genes, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin). Nurr1 agonist 12 exhibits neuroprotective efficacy against Paraquat-induced neurotoxicity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
