LRPAP1 Protein, Mouse (HEK293, His)
Based on 2 publication(s) in Google Scholar
Low density lipoprotein receptor-related protein associated protein 1 interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands.LRPAP1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LRPAP1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Low density lipoprotein receptor-related protein associated protein 1 interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands.LRPAP1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LRPAP1 protein, expressed by HEK293 , with C-6*His labeled tag.
Low density lipoprotein receptor-related protein associated protein 1 ( LRPAP1) interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. LRPAP1 is a widely expressed gene that encodes low density lipoprotein receptor-related protein-associated protein 1, a 357 amino acid protein that is thought to act as a chaperone that binds and protects the lipoprotein receptor-related proteins LRP1 and LRP2[1][2][3][4].
Immobilized Mouse LRPAP1 at 2 μg/mL (100 μL/well) can bind Biotinylated Mouse VLDLR protein (HY-P78049). The ED50 for this effect is < 0.6 nM.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell
2026 Apr 2;189(7):1923-1941.e26. PMID: 41785850 -
Kidney Dis (Basel)
The Effect of Low-Density Lipoprotein Receptor-Related Protein-1 on Acute Kidney Injury and Renal Tubular Epithelial Triglyceride Accumulation. [Abstract]2025 Apr 14;11(1):320-331. PMID: 40432903
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-6*His
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Accession
Q52KI7 (Q29-L360)
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Gene ID16976
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Molecular Construction
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N-term
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LRPAP1 (Q29-L360)
Accession # Q52KI7 -
6*His
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C-term
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Protein Length
Partial
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Synonyms
LRPAP1; Low Density Lipoprotein-Related Protein-Associated Protein 1 (Alpha-2-Macroglobulin Receptor-Associated Protein 1); Prev. A2MRAP; Low Density Lipoprotein Receptor-Related Protein-Associated Protein 1; Prev. RAP; 39 KDa Receptor-Associated Protein;
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AA Sequence
QPIAGHGGKYSREKNEPEMAAKRESGEEFRMEKLNQLWEKAKRLHLSPVRLAELHSDLKIQERDELNWKKLKVEGLDKDGEKEAKLIHNLNVILARYGLDGRKDAQMVHSNALNEDTQDELGDPRLEKLWHKAKTSGKFSSEELDKLWREFLHYKEKIQEYNVLLDTLSRAEEGYENLLSPSDMAHIKSDTLISKHSELKDRLRSINQGLDRLRKVSHQGYGSTTEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKIEKHNHYQKQLEISHQKLKHVESIGDPEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSRARHNEL
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Predicted Molecular Mass
39.8 kDa
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Molecular Weight
Approximately 42-45 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
1.Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
2.Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.
Please refer to the lot-specific COA for specific buffer information.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (264 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Aldahmesh MA, et al. Mutations in LRPAP1 are associated with severe myopia in humans. Am J Hum Genet. 2013 Aug 8;93(2):313-20. [Content Brief]
[2]. Wagner MC, et al. Lrpap1 (RAP) Inhibits Proximal Tubule Clathrin Mediated and Clathrin Independent Endocytosis, Ameliorating Renal Aminoglycoside Nephrotoxicity. Kidney360. 2023 May 1;4(5):591-605. [Content Brief]
[3]. Magliyah MS, et al. Rhegmatogenous Retinal Detachment in Nonsyndromic High Myopia Associated with Recessive Mutations in LRPAP1. Ophthalmol Retina. 2020 Jan;4(1):77-83. [Content Brief]
[4]. Thurner L, et al. LRPAP1 is a frequent proliferation-inducing antigen of BCRs of mantle cell lymphomas and can be used for specific therapeutic targeting. Leukemia. 2019 Jan;33(1):148-158. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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