1817628-40-2
1817628-40-2
Chemical Structure
PF-06426779
- CAS 番号: 1817628-40-2
- Formula:C17H18FN3O4
- Molecular Weight:347.34
IUPAC Name: 1-(((2S,3S,4S)-4-fluoro-3-methyl-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide
InChIKey: GISRWBROCYNDME-PELMWDNLSA-N
SMILES: O=C(C1=CC2=C(C(OC[C@H]([C@H](C)[C@@H]3F)NC3=O)=NC=C2)C=C1OC)N
Biological Activity: PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4), with an IC50 of 0.3 nM[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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PF-06426779 | 99.01% | PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4), with an IC50 of 0.3 nM. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.88
HY-19836Zimlovisertib -
Similarity Score 0.47
HY-148617ALDH2 modulator 1 -
Similarity Score 0.43
HY-N16714Clausine K -
Similarity Score 0.43
HY-105559AViquidil hydrochloride -
Similarity Score 0.42
HY-101720Fradafiban -
Similarity Score 0.42
HY-170673E3 Ligase Ligand-linker Conjugate 156 -
Similarity Score 0.42
HY-B1613Clebopride -
Similarity Score 0.42
HY-105559Viquidil -
Similarity Score 0.42
HY-15391RLucitanib (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Lee KL, et, al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13; 60(13): 5521-5542. [Content Brief]
