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LRPAP1 Protein, Mouse (HEK293, His, Solution)

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Based on 2 publication(s) in Google Scholar

Low density lipoprotein receptor-related protein associated protein 1 interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands.LRPAP1 Protein, Mouse (HEK293, His, Solution) is the recombinant mouse-derived LRPAP1 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Mouse
  • Source: HEK293
  • Storage:
    Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
  • Experimental Validation Results for LRPAP1 Protein, Mouse (HEK293, His, Solution)
  • LRPAP1 Protein, Mouse (HEK293, His, Solution) Product Image
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  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

Low density lipoprotein receptor-related protein associated protein 1 interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands.LRPAP1 Protein, Mouse (HEK293, His, Solution) is the recombinant mouse-derived LRPAP1 protein, expressed by HEK293 , with C-His labeled tag.

Background

Low density lipoprotein receptor-related protein associated protein 1 ( LRPAP1) interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. LRPAP1 is a widely expressed gene that encodes low density lipoprotein receptor-related protein-associated protein 1, a 357 amino acid protein that is thought to act as a chaperone that binds and protects the lipoprotein receptor-related proteins LRP1 and LRP2[1][2][3][4].

Verified Bioactivity

Measured by its binding ability in a functional ELISA . Immobilized mouse LRPAP1 at 0.5 μg/mL can bind human VLDLR with a linear range of 1.28-32 ng/mL.

Technical Parameters

  • Species Mouse
  • Source HEK293
  • Tag C-His
  • Accession

    Q52KI7 (Q29-L360)

  • Gene ID
    16976  [NCBI]
  • Molecular Construction
    • N-term
    • LRPAP1 (Q29-L360)
      Accession # Q52KI7
    • His
    • C-term
  • Protein Length

    Partial

  • Synonyms

    LRPAP1; Low Density Lipoprotein-Related Protein-Associated Protein 1 (Alpha-2-Macroglobulin Receptor-Associated Protein 1); Prev. A2MRAP; Low Density Lipoprotein Receptor-Related Protein-Associated Protein 1; Prev. RAP; 39 KDa Receptor-Associated Protein;

  • AA Sequence

    QPIAGHGGKYSREKNEPEMAAKRESGEEFRMEKLNQLWEKAKRLHLSPVRLAELHSDLKIQERDELNWKKLKVEGLDKDGEKEAKLIHNLNVILARYGLDGRKDAQMVHSNALNEDTQDELGDPRLEKLWHKAKTSGKFSSEELDKLWREFLHYKEKIQEYNVLLDTLSRAEEGYENLLSPSDMAHIKSDTLISKHSELKDRLRSINQGLDRLRKVSHQGYGSTTEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKIEKHNHYQKQLEISHQKLKHVESIGDPEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSRARHNEL

  • Predicted Molecular Mass

    40.4 kDa

  • Molecular Weight

    Approximately 46 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Solution

Formulation

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Storage & Stability

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
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ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     ≥ 95%, as determined by reducing SDS-PAGE.

  • LRPAP1 Protein, Mouse (HEK293, His, Solution) Product Image
    1/16
  • Experimental Validation Results for LRPAP1 Protein, Mouse (HEK293, His, Solution)
  • LRPAP1 Protein, Mouse (HEK293, His, Solution) Product Image